التفاصيل البيبلوغرافية
| العنوان: |
Periodontal therapy and treatment of hypertension-alternative to the pharmacological approach. A systematic review and meta-analysis. |
| المؤلفون: |
Sharma, Shiv1 (AUTHOR) 2434782S@student.gla.ac.uk, Sridhar, Swathi1 (AUTHOR) 2501780S@student.gla.ac.uk, McIntosh, Alasdair1,2 (AUTHOR) Alasdair.McIntosh@glasgow.ac.uk, Messow, Claudia-Martina1,2 (AUTHOR) Martina.Messow@glasgow.ac.uk, Aguilera, Eva Munoz1,3 (AUTHOR) eva.aguilera.15@ucl.ac.uk, Del Pinto, Rita1,4 (AUTHOR) rita.delpinto@univaq.it, Pietropaoli, Davide1,5 (AUTHOR) davide.pietropaoli@univaq.it, Gorska, Renata1,6 (AUTHOR) r_gorska@interia.pl, Siedlinski, Mateusz1,7 (AUTHOR) Mateusz.Siedlinski@uj.edu.pl, Maffia, Pasquale1,8,9 (AUTHOR) Pasquale.Maffia@glasgow.ac.uk, Tomaszewski, Maciej1,10 (AUTHOR) maciej.tomaszewski@manchester.ac.uk, Guzik, Tomasz J.1,7,11 (AUTHOR) Tomasz.Guzik@glasgow.ac.uk, D'Aiuto, Francesco1,3 (AUTHOR) f.daiuto@ucl.ac.uk, Czesnikiewicz-Guzik, Marta1,12 (AUTHOR) marta.czesnikiewicz-guzik@glasgow.ac.uk |
| المصدر: |
Pharmacological Research. Apr2021, Vol. 166, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*META-analysis, *SYSTOLIC blood pressure, *BLOOD pressure, *RANDOM effects model, *HYPERTENSION, *DRUG therapy |
| مستخلص: |
Quantitative comparison of the effects of intensive (IPT) or conventional (CPT) periodontal treatment on arterial blood pressure, endothelial function and inflammatory/metabolic biomarkers. A systematic search was conducted to identify randomized controlled trials (RCT) of IPT (supra and subgingival instrumentation). Eight RCTs were included in the meta-analysis. Difference in change of systolic blood pressure (SBP) and diastolic blood pressure (DBP) before and after IPT or CPT were the primary outcomes. The secondary outcomes included: endothelial function and selected inflammatory/anti-inflammatory (CRP, IL-6, IL-10, IFN-γ) and metabolic biomarkers (HDL, LDL, TGs). The overall effect estimates (pooled Weighted Mean Difference (WMD)) of the primary outcome for SBP and DBP was −4.3 mmHg [95%CI: −9.10–0.48], p = 0.08 and −3.16 mmHg [95%CI: −6.51–0.19], p = 0.06 respectively. These studies were characterized by high heterogeneity. Therefore, random effects model for meta-analysis was performed. Sub-group analyses confirmed statistically significant reduction in SBP [WMD = −11.41 mmHg (95%CI: −13.66, −9.15) P < 0.00001] and DBP [WMD = −8.43 mmHg (95%CI: −10.96,−5.91) P < 0.00001] after IPT vs CPT among prehypertensive/hypertensive patients, while this was not observed in normotensive individuals. The meta-analyses showed significant reductions in CRP and improvement of endothelial function following IPT at all analysed timepoints. IPT leads to improvement of the cardiovascular health in hypertensive and prehypertensive individuals. [Display omitted] [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
