التفاصيل البيبلوغرافية
| العنوان: |
Racial disparities in cascade testing for cancer predisposition genes. |
| المؤلفون: |
Kassem, Nawal M.1 (AUTHOR) nmkassem@iupui.edu, Althouse, Sandra K.1 (AUTHOR), Monahan, Patrick O.1 (AUTHOR), Hayes, Lisa1 (AUTHOR), Nielsen, Sarah M.2 (AUTHOR), Heald, Brandie2 (AUTHOR), Esplin, Edward D.2 (AUTHOR), Hatchell, Kathryn E.2 (AUTHOR), Ballinger, Tarah J.1 (AUTHOR) |
| المصدر: |
Preventive Medicine. Jul2023, Vol. 172, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*CANCER genes, *RACIAL inequality, *BLACK people, *GENETIC testing, *CANCER prevention |
| مستخلص: |
We sought to determine whether there are racial disparities in cascade testing rates and whether providing testing at no-charge impacts rates in Black and White at-risk-relatives (ARR). Probands with a pathogenic/likely pathogenic germline variant in a cancer predisposition gene were identified up to one year before and up to one year after cascade testing became no-charge in 2017. Cascade testing rates were measured as the proportion of probands who had at least one ARR obtain genetic testing through one commercial laboratory. Rates were compared between self-reported Black and White probands using logistic regression. Interaction between race and cost (pre/post policy) was tested. Significantly fewer Black probands than White probands had at least one ARR undergo cascade genetic testing (11.9% versus 21.7%, OR 0.49, 95% CI 0.39–0.61, p < 0.0001). This was seen both before (OR 0.38, 95% CI 0.24–0.61, p < 0.001) and after (OR 0.53, 95% CI 0.41–0.68, p < 0.001) the no-charge testing policy. Rates of an ARR undergoing cascade testing were low overall, and significantly lower in Black versus White probands. The magnitude of difference in cascade testing rates between Blacks and Whites did not significantly change with no-charge testing. Barriers to cascade testing in all populations should be explored in order to maximize the benefits of genetic testing for both treatment and prevention of cancer. • A racial disparity in cascade testing exists between Black and White individuals. • Cost is one barrier to cascade testing but did not mitigate the disparity seen. • Identification of these unique barriers would allow for future development of tailored interventions. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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