التفاصيل البيبلوغرافية
| العنوان: |
Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension |
| المؤلفون: |
Nakamura, Kazuo1, Yamagishi, Sho-ichi1 shoichi@med.kurume-u.ac.jp, Nakamura, Yayoi2, Takenaka, Katsuhiko1, Matsui, Takanori1, Jinnouchi, Yuko1, Imaizumi, Tsutomu1 |
| المصدر: |
Microvascular Research. Nov2005, Vol. 70 Issue 3, p137-141. 5p. |
| مصطلحات موضوعية: |
*HYPERTENSION, *PEOPLE with diabetes, *ANGIOTENSINS, *MESSENGER RNA |
| مستخلص: |
Abstract: There is a growing body of evidence that the advanced glycation end product (AGE)–their receptor (RAGE) system plays a central role in the pathogenesis of diabetic vascular complication. The renin–angiotensin system (RAS) contributes to the development and progression of diabetic angiopathy as well. However, the cross-talk between the AGE–RAGE system and the RAS is not fully understood. In this study, we examined the role of angiotensin II (Ang II) type 1 receptor system for RAGE expression in cultured endothelial cells (ECs) and in patients with essential hypertension. Ang II up-regulated RAGE mRNA levels of microvascular ECs and subsequently increased the soluble form of RAGE (sRAGE) expression in the medium of ECs, both of which were completely blocked by telmisartan, a commercially available Ang II type 1 receptor antagonist. Furthermore, telmisartan was found to decrease serum levels of sRAGE in patients with essential hypertension. These results demonstrate that sRAGE is released from the cell surface of Ang-II-exposed ECs. Our present study indicates that a cross-talk exists between the AGE–RAGE system and the RAS and suggests that serum levels of sRAGE may reflect endothelial RAGE expression. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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