التفاصيل البيبلوغرافية
| العنوان: |
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. |
| المؤلفون: |
Hollestelle, Antoinette, van der Baan, Frederieke H, Berchuck, Andrew, Johnatty, Sharon E, Aben, Katja K, Agnarsson, Bjarni A, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, van Altena, Anne M, Van Asperen, C J, van den Berg, David, van den Ouweland, Ans M W, van Doorn, Helena C, Goodman, Marc T, Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J, Vergote, Ignace, Mai, Phuong L, Poppe, Bruce, Bojesen, Anders, Verhoef, Senno, Vierkant, Robert A, Vijai, Joseph, Vitonis, Allison F, von Wachenfeldt, Anna, Walsh, Christine, Gore, Martin, Wang, Qin, Wang-Gohrke, Shan, Pylkäs, Katri, Balleine, Rosemary, Wappenschmidt, Barbara, Weischer, Maren, Bojesen, Stig E, Weitzel, Jeffrey N, Weltens, Caroline, Wentzensen, Nicolas, Whittemore, Alice S, Wilkens, Lynne R, Greene, Mark H, Radice, Paolo, Winqvist, Robert, Fridley, Brooke L, Wu, Anna H, Wu, Xifeng, Yang, Hannah P, Zaffaroni, Daniela, Bolla, Manjeet K, Pilar Zamora, M, Zheng, Wei, Ziogas, Argyrios, Ramus, Susan J, Chenevix-Trench, Georgia, Grip, Mervi, Mannermaa, Arto, Pharoah, Paul D P, Rookus, Matti A, Hooning, Maartje J, Goode, Ellen L, Bonanni, Bernardo, Brand, Judith S, Brauch, Hiltrud, Rebbeck, Timothy R, Brenner, Hermann, Brinton, Louise, Brooks-Wilson, Angela, Margolin, Sara, Gronwald, Jacek, Bruinsma, Fiona, Brunet, Joan, Brüning, Thomas, Budzilowska, Agnieszka, Bunker, Clareann H, Berger, Andreas, Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S, Caligo, Maria A, Mariette, Frederique, Campbell, Ian, Gschwantler Kaulich, Daphne, Carter, Jonathan, Chang-Claude, Jenny, Chanock, Stephen J, Reed, Malcolm W R, Claes, Kathleen B M, Collée, J Margriet, Cook, Linda S, Couch, Fergus J, Cox, Angela, Marme, Frederik, Cramer, Daniel, Cross, Simon S, Apicella, Carmel, Cunningham, Julie M, Rennert, Gad, Cybulski, Cezary, Czene, Kamila, Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, de la Hoya, Miguel, Martens, John W M, deFazio, Anna, Dennis, Joseph, Devilee, Peter, Risch, Harvey A, Guénel, Pascal, Dicks, Ed M, Diez, Orland, Doherty, Jennifer A, Domchek, Susan M, Dorfling, Cecilia M, Dörk, Thilo, Massuger, Leon F A G, Silva, Isabel Dos Santos, du Bois, Andreas, Gentry-Maharaj, Aleksandra, Dumont, Martine, Dunning, Alison M, Guzman, Starr R, Duran, Mercedes, Easton, Douglas F, Eccles, Diana, Edwards, Robert P, Ehrencrona, Hans, Maugard, Christine, Ejlertsen, Bent, Lindblom, Annika, Ekici, Arif B, Ellis, Steve D, Engel, Christoph, Eriksson, Mikael, Haeberle, Lothar, Fasching, Peter A, Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Mazoyer, Sylvie, Robson, Mark, Fletcher, Olivia, Fontaine, Annette, Fortuzzi, Stefano, Fostira, Florentia, Haiman, Christopher A, Hall, Per, Halverson, Sandra L, Hamann, Ute, Hansen, Thomas V O, Harter, Philipp, Rodriguez, Gustavo C, McGuffog, Lesley, Hartikainen, Jaana M, Arndt, Volker, Healey, Sue, Hein, Alexander, Heitz, Florian, Henderson, Brian E, Herzog, Josef, T Hildebrandt, Michelle A, Høgdall, Claus K, Romero, Atocha, Høgdall, Estrid, McGuire, Valerie, Hogervorst, Frans B L, Hopper, John L, Arnold, Norbert, Humphreys, Keith, Huzarski, Tomasz, Imyanitov, Evgeny N, Isaacs, Claudine, Jakubowska, Anna, Rossing, Mary Anne, Janavicius, Ramunas, Jaworska, Katarzyna, Friebel, Tara, Jensen, Allan, Jensen, Uffe Birk, Johnson, Nichola, Arun, Banu K, Jukkola-Vuorinen, Arja, Kabisch, Maria, Karlan, Beth Y, Rothstein, Joseph H, Kataja, Vesa, Kauff, Noah, Kelemen, Linda E, Bandera, Elisa V, Kerin, Michael J, Kiemeney, Lambertus A, Kjaer, Susanne K, Knight, Julia A, Arver, Brita, Knol-Bout, Jacoba P, Rudolph, Anja, Konstantopoulou, Irene, Kosma, Veli-Matti, Krakstad, Camilla, Kristensen, Vessela, McLean, Catriona, Kuchenbaecker, Karoline B, Kupryjanczyk, Jolanta, Laitman, Yael, Lambrechts, Diether, Lambrechts, Sandrina, Runnebaum, Ingo, Ashworth, Alan, Larson, Melissa C, Lasa, Adriana, Laurent-Puig, Pierre, Lazaro, Conxi, McNeish, Iain, Le, Nhu D, Le Marchand, Loic, Leminen, Arto, Lester, Jenny, Berger, Raanan, Levine, Douglas A, Li, Jingmei, Baglietto, Laura, Liang, Dong, Meindl, Alfons, Menegaux, Florence, Menéndez, Primitiva, Menkiszak, Janusz, Menon, Usha, Mensenkamp, Arjen R, Salani, Ritu, Miller, Nicola, Friedman, Eitan, Milne, Roger L, Barrowdale, Daniel, Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B, Müller, Heiko, Mulligan, Anna Marie, Muranen, Taru A, Salvesen, Helga B, Narod, Steven A, Nathanson, Katherine L, Friel, Grace, Ness, Roberta B, Neuhausen, Susan L, Bean, Yukie T, Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C, Nielsen, Sune F, Lindor, Noralane, Nordestgaard, Børge G, Nussbaum, Robert L, Odunsi, Kunle, Frost, Debra, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Beckmann, Lars, Olson, Janet E, Olson, Sara H, Gerdes, Anne-Marie, Oosterwijk, Jan C, Orlow, Irene, Orr, Nick, Orsulic, Sandra, Garber, Judy, Osorio, Ana, Ottini, Laura, Paul, James, Pearce, Celeste L, Beckmann, Matthias W, Sawyer, Elinor J, Pedersen, Inge Sokilde, Peissel, Bernard, Pejovic, Tanja, Pelttari, Liisa M, Perkins, Jo, García-Closas, Montserrat, Permuth-Wey, Jenny, Peterlongo, Paolo, Peto, Julian, Phelan, Catherine M, Schildkraut, Joellen M, Phillips, Kelly-Anne, Benitez, Javier, Piedmonte, Marion, Pike, Malcolm C, Platte, Radka, Plisiecka-Halasa, Joanna, Gayther, Simon A, Poole, Elizabeth M, Schmidt, Marjanka K, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Schrauder, Michael G, Schumacher, Fredrick, Beuselinck, Benoit, Lissowska, Jolanta, Schwaab, Ira, Antoniou, Antonis C, Scuvera, Giulietta, Sellers, Thomas A, Severi, Gianluca, Seynaeve, Caroline M, Shah, Mitul, Shrubsole, Martha, Siddiqui, Nadeem, Sieh, Weiva, Long, Jirong, Simard, Jacques, Bisogna, Maria, Giles, Graham G, Singer, Christian F, Sinilnikova, Olga M, Smeets, Dominiek, Sohn, Christof, Soller, Maria, Song, Honglin, Soucy, Penny, Lu, Karen H, Southey, Melissa C, Stegmaier, Christa, Stoppa-Lyonnet, Dominique, Glasspool, Rosalind, Bjorge, Line, Sucheston, Lara, Swerdlow, Anthony, Tangen, Ingvild L, Tea, Muy-Kheng, Teixeira, Manuel R, Lubinski, Jan, Terry, Kathryn L, Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J, Glendon, Gord, Tihomirova, Laima, Blomqvist, Carl, Tischkowitz, Marc, Toland, Amanda Ewart, Tollenaar, Rob A E M, Lundvall, Lene, Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Tsimiklis, Helen, Tung, Nadine, Godwin, Andrew K, Tworoger, Shelley S, Tyrer, Jonathan P, Bogdanova, Natalia V, Vachon, Celine M, Lurie, Galina, Van 't Veer, Laura J |
| بيانات النشر: |
Academic Press Inc Elsevier Science |
| سنة النشر: |
2016 |
| المجموعة: |
Hirsla - Landspítali University Hospital research archive |
| مصطلحات موضوعية: |
Brjóstakrabbamein, Arfgengi, Eggjastokkar, Krabbamein, PTT12, Breast Neoplasms, Treatment Outcome, Genetic Association Studies, Proto-Oncogene Proteins p21(ras), Ovarian Neoplasms |
| الوصف: |
To access publisher's full text version of this article click on the hyperlink at the bottom of the page ; Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370. ; Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers). ; We found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations. ; rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers. ; info:eu-repo/grantAgreement/EC/FP7/223175 Ovarian Cancer Research Fund PPD/RPCI.07 US National Cancer Institute GAME-ON Post-GWAS Initiative U19-CA148112 Wellcome Trust 076113 National Health and Medical Research Council Deutsche ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
1095-6859 |
| العلاقة: |
info:eu-repo/grantAgreement/EC/FP7/223175; http://dx.doi.orgTest/ 10.1016/j.ygyno.2015.04.034; No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. 2016, 141 (2):386-401 Gynecol. Oncol.; http://hdl.handle.net/2336/611704Test; Gynecologic oncology |
| DOI: |
10.1016/j.ygyno.2015.04.034 |
| الإتاحة: |
https://doi.org/10.1016/j.ygyno.2015.04.034Test
http://hdl.handle.net/2336/611704Test |
| حقوق: |
Archived with thanks to Gynecologic oncology ; National Consortium - Landsaðgangur |
| رقم الانضمام: |
edsbas.DCD17677 |
| قاعدة البيانات: |
BASE |
