دورية أكاديمية
Diagnostic performance and establishment of reference limits of HE4 in Korean healthy women
| العنوان: | Diagnostic performance and establishment of reference limits of HE4 in Korean healthy women |
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| المساهمون: | College of Medicine, Dept. of Obstetrics & Gynecology, Shinae Yu, Jin Kyung Lee, Jae-Hoon Kim, Hyosoon Park, Mi Yeon Lee, Seungho Ryu, Min-Jung Kwon, Hee-Yeon Woo, Kim, Jae Hoon |
| بيانات النشر: | Academic Press United States |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Algorithms, CA-125 Antigen/blood, Female, Humans, Middle Aged, Ovarian Neoplasms/blood, Ovarian Neoplasms/diagnosis, Proteins/analysis, Benign ovarian tumor, CA125, Human epididymis protein 4, Ovarian cancer, Risk of ovarian malignancy algorithm |
| الوصف: | OBJECTIVE: We aimed to establish distribution and reference limits of HE4 and risk of ovarian malignancy algorithm (ROMA) in healthy Korean women and investigated the factors influencing HE4 levels. We also investigated the diagnostic performances of HE4 and ROMA score, compared with CA125. METHODS: We collected specimens from 1809 healthy Korean women, 140 specimens from patients with ovarian cancers (OCs) and 123 specimens from patients with benign ovarian tumor. Serum HE4 and CA125 concentrations were measured using an electrochemiluminescence immunoassay. The receiver operator characteristic (ROC) curve analysis was done for ROMA, HE4, CA125 and combining of HE4 and CA125. RESULTS: HE4 level was influenced by age, not by menopausal status. The 97.5th percentile upper reference limit of HE4 of subjects <50years and �돟50year-old was 63.87pmol/L and 88.28pmol/L, respectively. The 97.5th percentile upper reference limits of ROMA score were 13.66 in premenopausal and 19.30 in postmenopausal women. The serum HE4 level was even lower in the patients with benign tumor compared to those in healthy controls. HE4 had significantly higher concentrations in OCs than benign ovarian tumor (P<0.001). ROMA and HE4 combined with CA125 or not performed better diagnostically than CA125 alone for distinguishing OCs, with AUCs of 0.844 for ROMA, 0.827 for combining of HE4 and CA125, 0.825 for HE4, and 0.795 for CA125. CONCLUSIONS: The reference limit of HE4 was different from those reported by other studies, suggesting racial or regional difference. HE4 and ROMA were better than CA125 for differentiation normal and benign ovarian tumor from OCs. (Word count: 253). ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0090-8258 1095-6859 |
| العلاقة: | GYNECOLOGIC ONCOLOGY; J00956; OAK-2016-06226; https://ir.ymlib.yonsei.ac.kr/handle/22282913/152319Test; http://www.sciencedirect.com/science/article/pii/S0090825816309714?via%3DihubTest; T201604202; GYNECOLOGIC ONCOLOGY, Vol.143(1) : 128-134, 2016 |
| DOI: | 10.1016/j.ygyno.2016.07.100 |
| الإتاحة: | https://doi.org/10.1016/j.ygyno.2016.07.100Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/152319Test http://www.sciencedirect.com/science/article/pii/S0090825816309714?via%3DihubTest |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.F8FD5D6F |
| قاعدة البيانات: | BASE |
| تدمد: | 00908258 10956859 |
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| DOI: | 10.1016/j.ygyno.2016.07.100 |