Spinal cord injury as a trigger to develop periodic leg movements during sleep: an evolutionary perspective
| العنوان: | Spinal cord injury as a trigger to develop periodic leg movements during sleep: an evolutionary perspective |
|---|---|
| المؤلفون: | Gerson Chadi, Rosana Cardoso Alves, Susana Cristina Lerosa Telles |
| المصدر: | Arquivos de Neuro-Psiquiatria v.70 n.11 2012 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Arquivos de Neuro-Psiquiatria, Vol 70, Iss 11, Pp 880-884 (2012) Arquivos de Neuro-Psiquiatria, Volume: 70, Issue: 11, Pages: 880-884, Published: NOV 2012 |
| بيانات النشر: | Academia Brasileira de Neurologia - ABNEURO, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Movement, spinal cord regeneration, nocturnal myoclonus syndrome, Nocturnal Myoclonus Syndrome, lcsh:RC321-571, Restless Legs Syndrome, mental disorders, medicine, Humans, Restless legs syndrome, Spinal cord injury, síndrome das pernas inquietas, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Spinal Cord Regeneration, Spinal Cord Injuries, regeneração da medula espinal, Perspective (graphical), fungi, Central pattern generator, medicine.disease, Sleep in non-human animals, Biological Evolution, Neurology, CpG site, Central Pattern Generators, restless legs syndrome, síndrome da mioclonia noturna, Neurology (clinical), Psychology, Neuroscience |
| الوصف: | The primary trigger to periodic limb movement (PLM) during sleep is still unknown. Its association with the restless legs syndrome (RLS) is established in humans and was reported in spinal cord injury (SCI) patients classified by the American Spinal Injury Association (ASIA) as A. Its pathogenesis has not been completely unraveled, though recent advances might enhance our knowledge about those malfunctions. PLM association with central pattern generator (CPG) is one of the possible pathologic mechanisms involved. This article reviewed the advances in PLM and RLS genetics, the evolution of CPG functioning, and the neurotransmitters involved in CPG, PLM and RLS. We have proposed that SCI might be a trigger to develop PLM. O gatilho principal para o desenvolvimento de movimentos periódicos dos membros (MPM) durante o sono ainda é desconhecido. A associação entre o MPM e a síndrome das pernas inquietas (SPI) em seres humanos já foi previamente estabelecida e relatada em pacientes com lesão medular (LM), classificados pela American Spinal Injury Association (ASIA) como A. A patogênese do MPM não foi completamente desvendada, apesar de avanços recentes poderem ampliar o conhecimento sobre essas disfunções. Um dos possíveis mecanismos patológicos envolvidos é o gerador de padrão central (GPC). Este artigo revisou os avanços na genética do MPM e da SPI, a evolução do funcionamento do GPC e os neurotransmissores relacionados ao GPC, ao MPM e à SPI. Foi proposta a hipótese de que a LM poderia ser um gatilho para deflagrar os MPM. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74d2e2ee382e5a0d31312eb7c7f03f8Test http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001100011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d74d2e2ee382e5a0d31312eb7c7f03f8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |