Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta
| العنوان: | Estesioneuroblastomas com extensão intracraniana: análise do potencial proliferative e conduta |
|---|---|
| المؤلفون: | Eva Dankoweit-Timpe, Lutz Osterwald, Helmut Ostertag, Madjid Samii, Marcos Tatagiba, Paulo Henrique Pires de Aguiar, Ramesh P. Babu |
| المصدر: | Arquivos de Neuro-Psiquiatria, Volume: 53, Issue: 3b, Pages: 577-586, Published: SEP 1995 Arquivos de Neuro-Psiquiatria v.53 n.3b 1995 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| بيانات النشر: | Academia Brasileira de Neurologia - ABNEURO, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Nasal cavity, Pathology, medicine.medical_specialty, MIB 1, medicine.medical_treatment, Nose Neoplasms, Anosmia, Esthesioneuroblastoma, Olfactory, radioterapia, Nose neoplasm, neuroblastoma, paranasal sinuses, medicine, Humans, Neoplasm Invasiveness, radiotherapy, Aged, Brain Neoplasms, business.industry, nervo olfatório, Postoperative complication, Middle Aged, Prognosis, Combined Modality Therapy, base craniana anterior, Radiation therapy, medicine.anatomical_structure, Paranasal sinuses, Neurology, Anterior cranial fossa, olfactory nerve, seios paranasais, Immunohistochemistry, Female, Neurology (clinical), anterior cranial base, Nasal Cavity, Neoplasm Recurrence, Local, medicine.symptom, business, Follow-Up Studies |
| الوصف: | A total of 15 patients with esthesioneuroblastomas were treated between 1978 and 1992 at the Neurosurgery Department, Nordstadt Hospital, Hannover. In 9 cases, the tumors invaded the anterior cranial fossa. One patient died before any surgical intervention. Eight tumors were operated by a combined paranasal and subfrontal approach. Gross total tumor removal was achieved in all cases. Apart from anosmia, the only postoperative complication was transient mental changes in one case. Immunohistochemical analyses with MIB 1 monoclonal antibodies, directed against recombinant parts of Ki-67 antigen, were performed to estimate the proliferative potential of the esthesioneuroblastomas. Most of the tumors showed high proliferating cell indexes, which ranged from 3 to 42% (mean, 16%). The proliferating cell index with MIB 1 showed a correlation with postoperative outcome, although this was not statistically significant. Esthesioneuroblastomas can be totally removed surgically. The proliferating cell index may reflect histologically the biological behavior of tumor. Long-term follow-up is mandatory, and imunohistochemical studies may be of help in predicting outcome. O índice proliferative celular tumoral de 8 casos cirúrgicos de estesioneuroblastomas com extensão intracraniana (9 com extensão intracraniana em um total de 15, coletados de 1978 a 1992 no Hospital Nordstadt de Hannover, Alemanha) foi avaliado através do anticorpo monoclonal MIB-1, notando -se uma correlação prognostica. A maioria dos tumores revelou índice proliferative) alto (3% a 42%, média de 16%) e a classificação histopatológica de Hyam foi utilizada. A ressecção foi radical em 100% dos casos e o acesso cirúrgico combinado (paranasal e subfrontal) o preconizado. Os autores apresentam revisão da literatura discutindo a sua casuística. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04c6aa9ffbef944e52f036866c5f3bdTest http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1995000400005&lng=en&tlng=enTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e04c6aa9ffbef944e52f036866c5f3bd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |