دورية أكاديمية
Comparison of systemic exposure to toxic and/or carcinogenic volatile organic compounds (VOCs) during vaping, smoking, and abstention.
| العنوان: | Comparison of systemic exposure to toxic and/or carcinogenic volatile organic compounds (VOCs) during vaping, smoking, and abstention. |
|---|---|
| المؤلفون: | St Helen, Gideon, Liakoni, Evangelia, Nardone, Natalie, Addo, Newton, Jacob, Peyton, Benowitz, Neal L |
| المصدر: | St Helen, Gideon; Liakoni, Evangelia; Nardone, Natalie; Addo, Newton; Jacob, Peyton; Benowitz, Neal L (2020). Comparison of systemic exposure to toxic and/or carcinogenic volatile organic compounds (VOCs) during vaping, smoking, and abstention. Cancer prevention research, 13(2), pp. 153-162. AACR 10.1158/1940-6207.CAPR-19-0356 |
| بيانات النشر: | AACR |
| سنة النشر: | 2020 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | Comparisons of systemic exposure to toxicants during monitored cigarette smoking, electronic cigarette (e-cigarette) use and abstention are needed to enhance our understanding of the risks of e-cigarette use (vaping). In a crossover study, we measured 10 mercapturic acid metabolites of volatile organic compounds (VOCs) in 24-h urine samples collected from 36 dual users (8 women) of e-cigarettes and cigarettes during two days of ad libitum vaping or cigarette-only use, and two days of enforced abstention. Concentrations of VOC metabolites were higher during smoking compared to vaping, except for the methylating agents metabolite. The fold-difference in concentrations when smoking relative to vaping ranged from 1.31 (1.06-1.61) (GM, 95% CI) (1,3-butadiene) to 7.09 (5.88-8.54) (acrylonitrile). Metabolites of acrylamide [fold difference of 1.21 (1.03-1.43)] and benzene [1.46 (1.13-1.90)] were higher during vaping compared to abstention. The 1,3-butadiene and propylene oxide metabolites were higher in variable-power tank users compared to users of cig-a-likes. E-cigarettes expose users to lower levels of toxic VOCs compared to cigarette smoking, supporting their harm reduction potential among smokers. However, some e-cigarettes expose users to VOCs such as acrylamide, benzene, and propylene oxide, and may pose health risks to nonsmoking users. The results of our study will inform regulators in assessing e-cigarettes with respect to the balance between its potential harm reduction for adult smokers and risk to nonsmoking users. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://boris.unibe.ch/133866Test/ |
| الإتاحة: | https://doi.org/10.1158/1940-6207.CAPR-19-0356Test https://boris.unibe.ch/133866/1/St.%20Helen.%20VOC%20Ecig%20crossover.CA%20Prev%202019.pdfTest https://boris.unibe.ch/133866/8/St.%20Helen.%20VOC%20Ecig%20crossover.CA%20Prev%202019.pdfTest https://boris.unibe.ch/133866Test/ |
| حقوق: | info:eu-repo/semantics/openAccess ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.9E91489 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |