QSAR Analysis of some N, N-diphenyl urea derivatives as CCR5 Receptor Antagonist
| العنوان: | QSAR Analysis of some N, N-diphenyl urea derivatives as CCR5 Receptor Antagonist |
|---|---|
| المؤلفون: | Piyush Ghode, Aloksingh Thakur, Sanmati K. Jain, Shekhar Verma, Yogesh Vaishnav, Chanchal Deep Kaur, Achal Mishra |
| المصدر: | Research Journal of Pharmacy and Technology. 11:3802 |
| بيانات النشر: | A and V Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Quantitative structure–activity relationship, 010405 organic chemistry, Stereochemistry, Chinese hamster ovary cell, Human immunodeficiency virus (HIV), Biological activity, CCR5 receptor antagonist, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, 0104 chemical sciences, law.invention, law, medicine, Recombinant DNA, Pharmacology (medical), Urea derivatives, Pharmacology, Toxicology and Pharmaceutics (miscellaneous) |
| الوصف: | Quantitative structure–activity relationship (QSAR) has been established for 29 molecules of N, N- diphenylureas, reported to inhibit the binding of RANTES to membranes prepared from Chinese hamster ovary (CHO) cells stably expressing recombinant human CCR5. Partial Least Square Regressions (PLSR) was used to generate the relationship between biological activity and calculated descriptors. Model with good statistical qualities was developed using the software VLIFE MDS 3.0. Validation of the model was done bycross validation, randomization, and external test set prediction. On the basis of the QSAR model, we calculated the activity and found that theexisting compounds were potent. |
| تدمد: | 0974-360X 0974-3618 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3d711d64e840506c4fdf92ca250cbd6fTest https://doi.org/10.5958/0974-360x.2018.00697.2Test |
| رقم الانضمام: | edsair.doi...........3d711d64e840506c4fdf92ca250cbd6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0974360X 09743618 |
|---|