Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Español de Acromegalia, REA)
| العنوان: | Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Español de Acromegalia, REA) |
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| المؤلفون: | Mestrón, Antonio, Webb, Susan M., Astorga, Ricardo, Benito, Pedro, Catalá, Miguel, Gaztambide, Sonia, Gómez, José Manuel, Halperín, Irene, Lucas-Morante, Tomás, Moreno, Basilio, Obiols, Gabriel, de Pablos, Pedro, Páramo, Concha, Picó, Antonio, Torres, Elena, Varela, César, Vázquez, José Antonio, Zamora, Juana, Albareda, Mercè, Gilabert, Montserrat, Sánchez-Covisa, Miguel Aguirre, Alcaraz Tafalla, Marisol, Alonso Troncoso, Isabel, Álvarez Escolà, Cristina, Andía Melero, Victor Manuel, Arranz Martín, Alfonso, Arribas Palomar, Luis, Ballesteros Pomar, María, Beitia Martín, Juan José, López, Pedro Benito, Bernabeu Morón, Ignacio, Blanco Carrera, Concepción, Blanco Samper, Benito, Boronat Cortés, Mauro, Carrera Santaliestra, Maria José, Castillo López, Luis, Cordero Diez, Ma del Mar, Costilla Martín, Enrique, Cózar León, Ma Victoria, Cuatrecasas Cambra, Guillem, De Luís Román, Daniel Antonio, de Miguel Novoa, Ma Paz, De Pablos Velasco, Pedro Luis, Del Pozo Picó, Carlos, Diez Gómez, Juan José, Díez Hernández, Alberto, Duran Rodríguez-Hervada, Alejandra, de Antonio, Isabel Esteva, Fajardo Montañana, Carmen, Forga Llenas, Lluís, Fraile Saez, Ángel Luis, Galvez Moreno, Ma Angeles, García Centera, José Andrés, Gargallo Fernández, Manuel, Gavilán Villarejo, Inmaculada, Gil del Álamo, Paloma, Gilsanz Peral, Alberto, Gippini Pérez, Antonio, Gómez Balaguer, Marcelino, Gómez, Luis Alberto, Gorgojo Martínez, Juan José, Guerrero Martínez, Eduardo, Hernández Bayo, Juan Angel, Hernández López, Antonio, Iglesias, Pedro, Illán Gómez, Fátima, Jaunsolo Barranechea, Miguel Ángel, Lecube Torelló, Albert, Liante Peñambía, Gaspar, López dela Torre Casares, Martin, López Hernández, Elena, López López, José, López-Guzmán, Antonio, Lucas Martín, Ana, Marazuela Azpiroz, Mónica, Marco Martínez, Amparo, Marco Mur, Ángel Luis, Martin Castillo, Fidel, Martín González, Tomás, Martínez Brocca, Maria Asunció, Megia Colet, Ana, Merino Torres, Juan Francisco, Morales Gorría, Ma José, Morales Perez, Francisco, Murillo Sanchis, Jesús, Muros de Fuentes, Ma Teresa, Páramo Fernández, Concepción, Pavón de Paz, Isabel, Pazos Toral, Fernando, Pérez Corral, Ma Begoña, Pérez Pérez, Antonio, Pi Barrio, J. Javier, Piedrola Morato, Gonzalo, Pou Torelló, José Ma, Puigdevall Gallego, Victor, Rodríguez Guerrero, Paloma, Rodríguez Roble, Azuzena, Romero Bobillo, Enrique, Ruano Vieitez, Belén |
| المساهمون: | 6506205045, 7402907929, 7006637866, 7005691601, 57196475447, 6601967212, 34770414700, 7006053764, 6602722752, 7004888145, 6602533540, 6602664493, 6701587192, 56954703100, 7101808498, 7006081205, 56822964800, 7007126312, 6603639843, 56259724300, 6505584032, 55177325200, 6507256699, 22633901700, 6507444443, 6507804239, 6506203449, 55923812200, 6507320035, 56262704100, 6505626122, 56635423800, 6505779661, 21736048400, 7801532866, 6507059695, 6504693642, 6503889048, 6504208512, 6505575256, 7006033864, 6507880850, 6603805479, 6507436670, 6508035039, 6507772842, 6505667578, 6506196421, 6507871833, 6602987832, 6507200582, 6507038066, 6505597195, 6602442938, 6603546375, 6603501664, 6602721487, 6506733022, 35575659100, 7202331899, 6507483772, 56157986500, 57199572342, 57052954400, 7006659849, 6603266852, 6505478062, 6508264775, 6504568221, 6504524583, 6603315583, 57197878936, 6701834423, 6701755088, 7004723223, 6507723312, 6507905090, 6507621954, 57188562747, 6507049727, 9336204300, 6602824949, 7801549596, 56128275500, 6508293179, 6601975594, 6506697310, 6603258314, 6506498792, 6508081183, 57198021538, 15770121700, 6505632705, 6602794859, 6602529370, 6503850647, 6504660675, 6602522216, 6504759972 |
| المصدر: | European Journal of Endocrinology [ISSN 0804-4643], v. 151, p. 439-446 |
| بيانات النشر: | 0804-4643 |
| سنة النشر: | 2004 |
| المجموعة: | Universidad de Las Palmas de Gran Canaria: Acceda |
| مصطلحات موضوعية: | 32 Ciencias médicas |
| الوصف: | Objective: To undertake a multicentre epidemiological study reflecting acromegaly in Spain. Design: Voluntary reporting of data on patients with acromegaly to an online database, by the managing physician. Methods: Data on demographics, diagnosis, estimated date of initial symptoms and diagnosis, pituitary imaging, visual fields, GH and IGF-I concentrations (requested locally), medical, radiotherapy and neurosurgical treatments, morbidity and mortality were collected. Results: Data were included for 1219 patients (60.8% women) with a mean age at diagnosis of 45 years (S.D. 14 years). Reporting was maximal in 1997 (2.1 cases per million inhabitants (c.p.m.) per year); prevalence was globally 36 c.p.m., but varied between 15.7 and 75.8 c.p.m. in different regions. Of 1196 pituitary tumours, most were macroadenomas (73%); 81% of these patients underwent surgery, 45% received radiotherapy and 65% were given medical treatment (somatostatin analogues in 68.3% and dopamine agonists in 31.4%). Cures (GH values (basal or after an oral glucose tolerance test) ,2 ng/ml, normal IGF-I, or both) were observed in 40.3% after surgery and 28.2% after radiotherapy. Hypertension (39.1%), diabetes mellitus (37.6%), hypopituitarism (25.7%), goitre (22.4%), carpal tunnel syndrome (18.7%) and sleep apnoea (13.2%) were reported as most frequent morbidities; 6.8% of the patients had cancer (breast in 3.1% of the women and colon in 1.2% of the cohort). Fifty-six patients died at a mean age of 60 years (S.D. 14 years), most commonly of a cardiovascular cause (39.4%); mortality was greater in patients given radiotherapy (hazard ratio 2.29; 95% confidence interval 1.03 to 5.08; P ¼ 0.026), and in those in whom GH and IGF-I concentrations were never normal (P , 0.001). Conclusions: This acromegaly registry offers a realistic overview of the epidemiological characteristics, treatment outcome and morbidity of acromegaly in Spain. As active disease and treatment with radiotherapy are associated with an increase in mortality, efforts to control ... |
| نوع الوثيقة: | other/unknown material |
| اللغة: | English |
| ردمك: | 978-7-244-25740-7 7-244-25740-6 |
| تدمد: | 0804-4643 |
| العلاقة: | European Journal of Endocrinology; http://hdl.handle.net/10553/43428Test; 446; 439; 151 |
| DOI: | 10.1530/eje.0.1510439 |
| الإتاحة: | https://doi.org/10.1530/eje.0.1510439Test http://hdl.handle.net/10553/43428Test |
| رقم الانضمام: | edsbas.297D9D58 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9787244257407 7244257406 |
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| تدمد: | 08044643 |
| DOI: | 10.1530/eje.0.1510439 |