The present work was devoted to the study of peptide bioregulators (Semax, Selank) in brain function disturbance compensation and brain asymmetry in primates. Semax and Selank exert differential cerebroprotective influences on brain function disturbances in primates. The compensatory and antiamnestic effects of Selank are more considerable and long-term. The cerebroprotective effects of Selank are particularly significant in anxiety and depression. The compensatory effects of Semax are more short-term. The spectrum of Semax influence is less significant; it influences expression of vegetative indicators. The Chronic Fatigue Syndrome (CFS) study focused on symptoms and the compensatory role of the heptapeptide Selank. New data were received, and computer analysis of EEG disturbances in monkeys during CFS development showed that more significant disturbances occurred in the left frontal cortex. CFS changed handling reactions. After Selank administration, handling reactions were restored to normal.
