التفاصيل البيبلوغرافية
| العنوان: |
DataSheet1_The Association Between Cyclooxygenase-2 –1195G/A (rs689466) Gene Polymorphism and the Clinicopathology of Lung Cancer in the Japanese Population: A Case-Controlled Study.docx |
| المؤلفون: |
Rong Sun, Ryosuke Tanino, Xuexia Tong, Minoru Isomura, Li-Jun Chen, Takamasa Hotta, Tamio Okimoto, Megumi Hamaguchi, Shunichi Hamaguchi, Yasuyuki Taooka, Takeshi Isobe, Yukari Tsubata |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Genetics, Genetic Engineering, Biomarkers, Developmental Genetics (incl. Sex Determination), Epigenetics (incl. Genome Methylation and Epigenomics), Gene Expression (incl. Microarray and other genome-wide approaches), Genome Structure and Regulation, Genomics, Genetically Modified Animals, Livestock Cloning, Gene and Molecular Therapy, cyclooxygenase-2, single nucleotide polymorphism, promoter region, lung cancer risk, squamous cell carcinoma, Japanese |
| الوصف: |
The single nucleotide polymorphisms of COX-2 gene, also known as PTGS2, which encodes a pro-inflammatory factor cyclooxygenase-2, alter the risk of developing multiple tumors, but these findings are not consistent for lung cancer. We previously reported that the homozygous COX-2 –1195A genotype is associated with an increased risk for chronic obstructive pulmonary disease (COPD) in Japanese individuals. COPD is a significant risk factor for lung cancer due to genetic susceptibility to cigarette smoke. In this study, we investigated the association between COX-2 –1195G/A polymorphism and lung cancer susceptibility in the Japanese population. We evaluated the genotype distribution of COX-2 –1195G/A using a polymerase chain reaction-restriction fragment length polymorphism assay for 330 newly diagnosed patients with lung cancer and 162 healthy controls. Our results show that no relationship exists between the COX-2 –1195G/A polymorphism and the risk of developing lung cancer. However, compared to the control group, the homozygous COX-2 –1195A genotype increased the risk for lung squamous cell carcinoma (odds ratio = 2.902; 95% confidence interval, 1.171–7.195; p = 0.021), whereas no association is observed with the risk for adenocarcinoma. In addition, Kaplan-Meier analysis shows that the genotype distribution of homozygous COX-2 –1195A does not correlate with the overall survival of patients with lung squamous cell carcinoma. Thus, we conclude that the homozygous COX-2 –1195A genotype confers an increased risk for lung squamous cell carcinoma in Japanese individuals and could be used as a predictive factor for early detection of lung squamous cell carcinoma. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/DataSheet1_The_Association_Between_Cyclooxygenase-2_1195G_A_rs689466_Gene_Polymorphism_and_the_Clinicopathology_of_Lung_Cancer_in_the_Japanese_Population_A_Case-Controlled_Study_docx/19517977Test |
| DOI: |
10.3389/fgene.2022.796444.s001 |
| الإتاحة: |
https://doi.org/10.3389/fgene.2022.796444.s001Test
https://figshare.com/articles/dataset/DataSheet1_The_Association_Between_Cyclooxygenase-2_1195G_A_rs689466_Gene_Polymorphism_and_the_Clinicopathology_of_Lung_Cancer_in_the_Japanese_Population_A_Case-Controlled_Study_docx/19517977Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.4DACE016 |
| قاعدة البيانات: |
BASE |
