Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study.

التفاصيل البيبلوغرافية
العنوان:	Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study.
المؤلفون:	NIN JW, FERREIRA I, SCHALKWIJK CG, PRINS MH, CHATURVEDI N, FULLER JH, STEHOUWER CD, KARAMANOS B, KOFINIS A, PETROU K, GIORGINO, Francesco, PICCA G, ANGARANO A, DE PERGOLA, Giovanni, LAVIOLA L, GIORGINO R, IONESCU TIRGOVISTE C, COSZMA A, GUJA C, SONGINI M, CASU A, PEDRON M, PINTUS S, FOSSARELLO M, FERRISS JB, GREALY G, KEEFE DO, TOELLER M, ARDEN C, ROTTIERS R, TUYTTENS C, PRIEM H, EBELING P, KYLLIÄINEN M, KOIVISTO VA, IDZIOR WALUS B, SIERADZKI J, CYGANEK K, SOLNICA B, LEMKES HH, LEMKES STUFFKEN JC, NUNES CORREA J, ROGADO MC, GARDETE CORREIA L, CARDOSO MC, SILVA A, BOAVIDA J, MACHADO SA MARQUES M, MICHEL G, WIRION R, CARDILLO S, POZZA G, MANGILI R, ASNAGHI V, STANDL E, SCHAFFLER B, BRAND H, HARMS A, BEN SOUSSAN D, VERIER MINE O, FALLAS P, FALLAS MC, HOLLOWAY J, ASBURY L, BETTERIDGE DJ, CATHELINEAU G, BOUALLOUCHE A, VILLATTE CATHELINEAU B, SANTEUSANIO F, ROSI G, D'ALESSANDRO V, CAGINI C, BOTTINI P, REBOLDI GP, NAVALESI R, PENNO G, BANDINELLI S, MICCOLI R, NANNIPIERI M, GHIRLANDA G, SAPONARA C, COTRONEO P, MANTO A, MINNELLA A, WARD JD, TESFAYE S, EATON S, MODY C, BORRA M, CAVALLO PERIN P, GIUNTI S, GRASSI G, PAGANO GF, PORTA M, SIVIERI R, VITELLI F, VEGLIO M, PAPAZOGLOU N, MANES G, MUGGEO M, IAGULLI M, IRSIGLER K, ABRAHAMIAN H, WALFORD S, SINCLAIR J, HUGHES S, MCLELLAND V, WARD J, ROGLIC G, METELKO Z, PEPEONIK ZR, SJOLIE AK, FERRISS B, WEBB D, VIBERTI GC, SWAMINATHAN R, LUMB P, COLLINS A, SANKARALINGHAM S, ALDINGTON S, MORTEMORE T, LIPINSKI H.
المساهمون:	Nin, Jw, Ferreira, I, Schalkwijk, Cg, Prins, Mh, Chaturvedi, N, Fuller, Jh, Stehouwer, Cd, Karamanos, B, Kofinis, A, Petrou, K, Giorgino, Francesco, Picca, G, Angarano, A, DE PERGOLA, Giovanni, Laviola, L, Giorgino, R, IONESCU TIRGOVISTE, C, Coszma, A, Guja, C, Songini, M, Casu, A, Pedron, M, Pintus, S, Fossarello, M, Ferriss, Jb, Grealy, G, Keefe, Do, Toeller, M, Arden, C, Rottiers, R, Tuyttens, C, Priem, H, Ebeling, P, Kylliäinen, M, Koivisto, Va, IDZIOR WALUS, B, Sieradzki, J, Cyganek, K, Solnica, B, Lemkes, Hh, LEMKES STUFFKEN, Jc, NUNES CORREA, J, Rogado, Mc, GARDETE CORREIA, L, Cardoso, Mc, Silva, A, Boavida, J, MACHADO SA MARQUES, M, Michel, G, Wirion, R, Cardillo, S, Pozza, G, Mangili, R, Asnaghi, V, Standl, E, Schaffler, B, Brand, H, Harms, A, BEN SOUSSAN, D, VERIER MINE, O, Fallas, P, Fallas, Mc, Holloway, J, Asbury, L, Betteridge, Dj, Cathelineau, G, Bouallouche, A, VILLATTE CATHELINEAU, B, Santeusanio, F, Rosi, G, D'Alessandro, V, Cagini, C, Bottini, P, Reboldi, Gp, Navalesi, R, Penno, G, Bandinelli, S, Miccoli, R, Nannipieri, M, Ghirlanda, G, Saponara, C, Cotroneo, P, Manto, A, Minnella, A, Ward, Jd, Tesfaye, S, Eaton, S, Mody, C, Borra, M, CAVALLO PERIN, P, Giunti, S, Grassi, G, Pagano, Gf, Porta, M, Sivieri, R, Vitelli, F, Veglio, M, Papazoglou, N, Manes, G
سنة النشر:	2012
المجموعة:	Università degli Studi di Bari Aldo Moro: CINECA IRIS
الوصف:	CONTEXT AND OBJECTIVE: High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein. DESIGN AND METHODS: This was a cross-sectional nested case-control study of 463 patients (226 women; mean age 40±10 years) with type 1 diabetes from the EURODIAB Prospective Complications Study. We used linear and binary or multinomial logistic regression analyses adjusted for traditional risk factors. RESULTS: Serum Ln-HMGB1 levels were positively associated with LGI and ED (standardised β=0.07 (95% confidence interval (CI): 0.02-0.12) and β=0.08 (95% CI: 0.02-0.14) respectively), but not with PP. Higher Ln-HMGB1 (per unit) was associated with greater odds of micro- and macroalbuminuria: odds ratio (OR)=1.24 (95% CI: 0.90-1.71) and OR=1.61 (95% CI: 1.15-2.25) respectively, P for trend=0.004. Further adjustments for LGI or ED did not attenuate these associations. No such associations were found between Ln-HMGB1 and estimated glomerular filtration rate (eGFR), retinopathy or CVD, however. CONCLUSIONS: In type 1 diabetes, higher serum HMGB1 levels are associated with greater prevalence and severity of albuminuria, though not with eGFR, retinopathy and CVD. Prospective studies are needed to clarify the causal role of HMGB1, if any, in the pathogenesis of vascular complications in type 1 diabetes.
نوع الوثيقة:	article in journal/newspaper
اللغة:	unknown
العلاقة:	volume:166; issue:2; firstpage:325; lastpage:332; numberofpages:8; journal:EUROPEAN JOURNAL OF ENDOCRINOLOGY; http://hdl.handle.net/11586/130485Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84856078195
الإتاحة:	http://hdl.handle.net/11586/130485Test
رقم الانضمام:	edsbas.BD64EA6C
قاعدة البيانات:	BASE

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