التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Platelet-to-Albumin Ratio: A Novel IgA Nephropathy Prognosis Predictor.docx |
| المؤلفون: |
Jiaxing Tan, Guojiao Song, Siqing Wang, Lingqiu Dong, Xiang Liu, Zheng Jiang, Aiya Qin, Yi Tang, Wei Qin |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, platelet-to-albumin ratio, IgA nephropathy, prognosis, cohort study, end-stage renal desease |
| الوصف: |
Background Chronic inflammation is related to the development of IgA nephropathy (IgAN). Emerging studies have reported that platelet-related parameters including platelet (PLT), platelet-to-albumin ratio (PAR), and platelet-to-lymphocyte ratio (PLR) are proved to be novel prognostic indicators for several inflammatory diseases. Whether platelet-related parameters could serve as predictors for IgAN remains unknown. Methods A total of 966 IgAN patients were enrolled in this retrospective study and were divided into several groups based on the optimal cut-off value of the platelet-related parameters. End-stage renal disease was used as the renal endpoint. A 1:2 propensity score (PS) match was then carried out to eliminate significant differences at baseline. The area under the receiver operating characteristic curve (AUROC), Kaplan–Meier (K-M) curve, and Cox proportional hazards analyses were performed to evaluate their predictive effect. Results Without considering the effect of covariates, the K-M curve showed that PLT, PLR, and PAR were strongly correlated with the renal outcomes of IgAN. However, the AUROC revealed that the PAR and PLR had better predictive power than the PLT. Multivariate Cox regression adjusting for demographic data, pathological findings, treatment, and laboratory results indicated that compared with PLR, albumin and PLT, PAR seemed to be a better marker of adverse renal outcome, implying that PAR was the only platelet-related parameter that could be used as an independent risk factor. Notably, high PAR patients seemed to have more severe clinical manifestations and pathological lesions. However, after eliminating the influence of different baselines on outcome variables, the PAR could still predict the poor prognosis of IgAN. To more accurately evaluate the predictive power of the PAR, we analyzed the predictive effect of the PAR on patients with different clinicopathological characteristics through subgroup analysis. It was indicated that the PAR might better predict the prognosis and ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/DataSheet_1_Platelet-to-Albumin_Ratio_A_Novel_IgA_Nephropathy_Prognosis_Predictor_docx/19791421Test |
| DOI: |
10.3389/fimmu.2022.842362.s001 |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2022.842362.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Platelet-to-Albumin_Ratio_A_Novel_IgA_Nephropathy_Prognosis_Predictor_docx/19791421Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.89B39723 |
| قاعدة البيانات: |
BASE |
