دورية أكاديمية
A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C
| العنوان: | A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C |
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| المؤلفون: | Varchetta, Stefania, Mele, Dalila, D'Ambrosio, Roberta, Perbellini, Riccardo, Lombardi, Andrea, Rojas, Ángela, Paolucci, Stefania, Baldanti, Fausto, Oliviero, Barbara, Mantovani, Stefania, Tinelli, Carmine, De Silvestri, Annalisa, Romero-Gómez, Manuel, Lampertico, Pietro, Mondelli, Mario U. |
| المساهمون: | Ministero della Salute |
| بيانات النشر: | John Wiley & Sons |
| سنة النشر: | 2021 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Chronic hepatitis C, Diagnosis, Liver fibrosis, Siglec-7 |
| الوصف: | Previous evidence suggests that sialic acid-binding Ig-like lectin 7 (Siglec-7) protein is significantly increased in patients with chronic hepatitis C virus (HCV) infection and directly correlates with clinical parameters of liver inflammation and fibrosis. The aim of this study was to determine the diagnostic value of Siglec-7 as a non-invasive tool to assess liver fibrosis in patients with chronic hepatitis C in a cross-sectional study. Serum levels of Siglec-7 were retrospectively tested in 1007 consecutive patients with chronic HCV infection recruited at three different European sites and data examined by the ‘imperfect gold-standard’ statistical analysis. Liver stiffness obtained by transient elastography (TE) was considered the standard reference. Liver fibrosis was staged according to published cut-offs of liver stiffness measurement by TE. Accuracy of detection of liver fibrosis stage was not increased by Siglec-7 alone. However, we developed a new index (SiGAP) including Siglec-7, γ-glutamyl transferase, age and platelet count which showed increased sensitivity and specificity in predicting fibrosis compared with APRI or FIB4 indices. The AUROC of SiGAP for the diagnosis of significant (≥F2) and advanced liver fibrosis (≥F3) showed significantly higher values than those of APRI and FIB-4. Siglec-7 may be useful as a complementary tool to assess liver fibrosis stage in patients with chronic hepatitis C when included in a specifically designed algorithm, which showed high level of accuracy in the detection of F2 and F3 fibrosis stage. ; This study was supported by funds from the Italian Ministry of Health to Fondazione IRCCS Policlinico San Matteo (RC08056517). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1352-0504 |
| العلاقة: | http://dx.doi.org/10.1111/jvh.13570Test; Sí; e-issn: 1365-2893; Journal of Viral Hepatitis 28(10): 1443-1451 (2021); http://hdl.handle.net/10261/266358Test; http://dx.doi.org/10.13039/501100003196Test |
| DOI: | 10.1111/jvh.13570 |
| DOI: | 10.13039/501100003196 |
| الإتاحة: | https://doi.org/10.1111/jvh.13570Test https://doi.org/10.13039/501100003196Test http://hdl.handle.net/10261/266358Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.45717587 |
| قاعدة البيانات: | BASE |
| تدمد: | 13520504 |
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| DOI: | 10.1111/jvh.13570 |