التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_Hypertension, cerebral Amyloid, aGe Associated Known neuroimaging markers of cerebral small vessel disease Undertaken with stroke REgistry (HAGAKURE) prospective cohort study: Baseline characteristics and association of cerebral small vessel disease with prognosis in an ischemic stroke cohort.pdf |
| المؤلفون: |
Shuhei Ikeda, Yusuke Yakushiji, Jun Tanaka, Masashi Nishihara, Atsushi Ogata, Makoto Eriguchi, Shohei Ono, Masafumi Kosugi, Kohei Suzuyama, Megumi Mizoguchi, Chika Shichijo, Toshihiro Ide, Yukiko Nagaishi, Hodo Mori, Natsuki Ono, Masaaki Yoshikawa, Kiku Ide, Hiromu Minagawa, Kotaro Iida, Kazuhiro Kawamoto, Yoshiko Katsuki, Hiroyuki Irie, Tatsuya Abe, Hideo Hara |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Neuroscience, Pathology, Health Care, Psychiatry (incl. Psychotherapy), Clinical Sciences not elsewhere classified, Central Nervous System, Aged Care Nursing, Aged Health Care, Protein Trafficking, small vessel disease (SVD), cerebral Amyloid aGe (CAA), magnetic resonance imaging (MRI), hypertension, ischemic stroke (IS) |
| الوصف: |
Introduction Cerebral small vessel disease (SVD) is one of the leading causes of stroke; each neuroimaging marker of SVD is correlated with vascular risk factors and associated with poor prognosis after stroke. However, longitudinal studies investigating the association between comprehensive SVD burden scoring system, “total SVD score” – which encompasses the established neuroimaging markers of lacunae, cerebral microbleeds (CMBs), white matter hyperintensities (WMH) including periventricular hyperintensities, and perivascular spaces in basal ganglia– and clinical outcomes are limited. The aim of this study is to determine the association between SVD burden and long-term prognosis in patients with ischemic stroke. Methods and design This prospective, single-center, observational study enrolled patients with acute ischemic stroke, including cerebral infarction and transient ischemic attack. Magnetic resonance imaging scans were performed, and then total SVD score (range, 0–4) was calculated. We recorded baseline characteristics and evaluated the relationships of long-term outcomes to SVD neuroimaging markers and total SVD score. Stroke recurrence was thought as primary outcome. Hazard ratios (HRs) of events during follow-up were calculated using Cox proportional hazards modeling with adjustments for age, sex, hypertension, dyslipidemia, diabetes mellitus, atrial fibrillation, and smoking. Cumulative event rates were estimated using the Kaplan–Meier method. Results Consecutive 564 acute ischemic stroke patients were enrolled according to inclusion and exclusion criteria. A total of 467 participants with first-ever ischemic stroke were analyzed (median age 75.0 [interquartile range, 64.0–83.0] years, 59.3% male). Total SVD score was 0 point in 47 individuals (12.0%), 1 point in 83 (21.2%), 2 points in 103 (26.3%), 3 points in 85 (21.7%), and 4 points in 73 (18.7%). Twenty-eight recurrent stroke events were identified during follow-up. Total SVD score ≥ 2, presence of CMBs, and moderate-to-severe WMH were associated ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Data_Sheet_1_Hypertension_cerebral_Amyloid_aGe_Associated_Known_neuroimaging_markers_of_cerebral_small_vessel_disease_Undertaken_with_stroke_REgistry_HAGAKURE_prospective_cohort_study_Baseline_characteristics_and_association_of_cerebral_sma/22202815Test |
| DOI: |
10.3389/fnagi.2023.1117851.s001 |
| الإتاحة: |
https://doi.org/10.3389/fnagi.2023.1117851.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Hypertension_cerebral_Amyloid_aGe_Associated_Known_neuroimaging_markers_of_cerebral_small_vessel_disease_Undertaken_with_stroke_REgistry_HAGAKURE_prospective_cohort_study_Baseline_characteristics_and_association_of_cerebral_sma/22202815Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.6F09F6A8 |
| قاعدة البيانات: |
BASE |
