التفاصيل البيبلوغرافية
| العنوان: |
White matter microstructural perturbations after total sleep deprivation in depression |
| المؤلفون: |
Taraku, Brandon, Zavaliangos-Petropulu, Artemis, Loureiro, Joana R., Al-Sharif, Noor B., Kubicki, Antoni, Joshi, Shantanu H., Woods, Roger P., Espinoza, Randall, Narr, Katherine L., Sahib, Ashish K. |
| المساهمون: |
National Institute of Mental Health, National Institutes of Health |
| المصدر: |
Frontiers in Psychiatry ; volume 14 ; ISSN 1664-0640 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Psychiatry and Mental health |
| الوصف: |
Background Total sleep deprivation (TSD) transiently reverses depressive symptoms in a majority of patients with depression. How TSD modulates diffusion tensor imaging (DTI) measures of white matter (WM) microstructure, which may be linked with TSD’s rapid antidepressant effects, remains uncharacterized. Methods Patients with depression ( N = 48, mean age = 33, 26 women) completed diffusion-weighted imaging and Hamilton Depression Rating (HDRS) and rumination scales before and after >24 h of TSD. Healthy controls (HC) ( N = 53, 23 women) completed the same assessments at baseline, and after receiving TSD in a subset of HCs ( N = 15). Tract based spatial statistics (TBSS) investigated voxelwise changes in fractional anisotropy (FA) across major WM pathways pre-to-post TSD in patients and HCs and between patients and HCs at baseline. Post hoc analyses tested for TSD effects for other diffusion metrics, and the relationships between change in diffusion measures with change in mood and rumination symptoms. Results Significant improvements in mood and rumination occurred in patients with depression (both p < 0.001), but not in HCs following TSD. Patients showed significant ( p < 0.05, corrected) decreases in FA values in multiple WM tracts, including the body of the corpus callosum and anterior corona radiata post-TSD. Significant voxel-level changes in FA were not observed in HCs who received TSD ( p > 0.05). However, differential effects of TSD between HCs and patients were found in the superior corona radiata, frontal WM and the posterior thalamic radiation ( p < 0.05, corrected). A significant ( p < 0.05) association between change in FA and axial diffusivity within the right superior corona radiata and improvement in rumination was found post-TSD in patients. Conclusion Total sleep deprivation leads to rapid microstructural changes in WM pathways in patients with depression that are distinct from WM changes associated with TSD observed in HCs. WM tracts including the ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fpsyt.2023.1195763 |
| DOI: |
10.3389/fpsyt.2023.1195763/full |
| الإتاحة: |
https://doi.org/10.3389/fpsyt.2023.1195763Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.EB42A614 |
| قاعدة البيانات: |
BASE |
