المؤلفون: Hummel, Nikolas R., Zuo, Kevin J., Talbot, Simon, Zimmerman, Zoe E., Katz, Jeffrey N., Kinsley, Sarah E., Kumnig, Martin

المصدر: Frontiers in Psychology ; volume 14 ; ISSN 1664-1078

مصطلحات موضوعية: General Psychology

الوصف: Background The impact of patient-specific psychosocial factors on functional outcomes after upper-extremity (UE) vascularized composite allotransplantation (VCA) is poorly understood. The objective of this study was to identify relevant psychosocial predictors for success or failure of UE VCA in an Austrian cohort. Methods A qualitative study was undertaken consisting of semi-structured interviews with UE VCA staff, transplanted patients, and close relatives. Participants were asked about their perceptions of factors that either favored or hindered a successful transplant outcome, including functional status before surgery, preparation for transplant, decision-making, rehabilitation and functional outcome after surgery, and family and social support. Interviews were conducted online and recorded with the consent of interviewees. Results Four bilateral UE VCA patients, 7 healthcare professionals, and a sister of a patient participated in the study. Thematic analysis revealed the importance of an expert interdisciplinary team with adequate resources for patient selection. Psychosocial aspects of prospective candidates are crucial to evaluate as they contribute to success. Both patients and providers may be impacted by public perceptions of UE VCA. Functional outcomes are optimized with a life-long commitment to rehabilitation as well as close, ongoing provider involvement. Conclusion Psychosocial factors are important elements in the assessment and follow-up care for UE VCA. To best capture psychosocial elements of care, protocols must be individualized, patient-centered, and interdisciplinary. Investigating psychosocial predictors and collecting outcomes is, thus, critical to justifying UE VCA as a medical intervention and to providing accurate and salient information to prospective candidates.

الإتاحة: https://doi.org/10.3389/fpsyg.2023.1092725Test

المؤلفون: Lowenstein, Natalie, Chang, Yuchiao, Mass, Hanna, Mercurio, Angela M., Ukogu, Chierika, Katz, Jeffrey N., Matzkin, Elizabeth G.

المصدر: Alpha Omega Alpha Research Symposium Posters

مصطلحات موضوعية: knee arthroscopy, partial meniscectomy, patient reported outcomes, PROMs, Medicine and Health Sciences, Surgery

الوصف: Problem Statement: - Arthroscopic partial meniscectomy (APM) has been shown to be the most common meniscal surgical treatment in the United States - Pre-op risk factors known to contribute to poor outcomes after APM: Symptom duration and radiographic OA at baseline - Factors with no conclusive effect on post-op outcomes: Baseline knee functional score, location of meniscal tear, BMI, activity level, age, sex, and chondral damage on MRI Project AIM: To create an index score using easily available preoperative risk factors such as Kellgren-Lawrence (KL) grade, age, duration of symptoms, BMI, activity level, and preoperative outcome scores to predict the likelihood of favorable outcomes after APM. ; https://jdc.jefferson.edu/aoa_research_symposium_posters/1003/thumbnail.jpgTest

وصف الملف: application/pdf

العلاقة: https://jdc.jefferson.edu/aoa_research_symposium_posters/4Test; https://jdc.jefferson.edu/context/aoa_research_symposium_posters/article/1003/viewcontent/Lowenstein_Natalie_poster.pdfTest

الإتاحة: https://jdc.jefferson.edu/aoa_research_symposium_posters/4Test
https://jdc.jefferson.edu/context/aoa_research_symposium_posters/article/1003/viewcontent/Lowenstein_Natalie_poster.pdfTest

المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Katz, Jeffrey N, Nevitt, Michael C, Lynch, John A, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Arthritis Care & Research, vol 74, iss 7

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biomedical Imaging, Pain Research, Arthritis, Aging, Chronic Pain, Clinical Research, Musculoskeletal, Biomarkers, Cartilage, Articular, Disease Progression, Humans, Knee Joint, Magnetic Resonance Imaging, National Institutes of Health (U.S.), Osteoarthritis, Knee, Synovitis, United States, Public Health and Health Services, Psychology, Allied health and rehabilitation science

الوقت: 1142 - 1153

الوصف: ObjectiveTo determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression.MethodsThe present study was a nested case-control trial from the Foundation of the National Institutes of Health OA Biomarkers Consortium that assessed study participants with a Kellgren/Lawrence grade of 1-3 who had complete biomarker data available (n = 539 to 550). Cases were participants' knees that had radiographic and pain progression between 24 and 48 months compared to baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) that had a P value of <0.10 in univariate analysis were selected, including quantitative cartilage thickness and volume on magnetic resonance imaging (MRI), semiquantitative MRI markers, bone shape and area, quantitative meniscal volume, radiographic progression (trabecular bone texture [TBT]), and serum and/or urine biochemical markers. Multivariable logistic regression models were built using 3 different stepwise selection methods (complex models versus parsimonious models).ResultsAmong baseline biomarkers, the number of locations affected by osteophytes (semiquantitative), quantitative central medial femoral and central lateral femoral cartilage thickness, patellar bone shape, and semiquantitative Hoffa-synovitis predicted OA progression in most models (C statistic 0.641-0.671). In most models, 24-month changes in semiquantitative MRI markers (effusion-synovitis, meniscal morphologic changes, and cartilage damage), quantitative central medial femoral cartilage thickness, quantitative medial tibial cartilage volume, quantitative lateral patellofemoral bone area, horizontal TBT (intercept term), and urine N-telopeptide of type I collagen predicted OA progression (C statistic 0.680-0.724). A different combination of imaging and biochemical biomarkers (baseline and 24-month change) predicted radiographic progression only, which had a higher C statistic of ...

وصف الملف: application/pdf

العلاقة: qt64n63926; https://escholarship.org/uc/item/64n63926Test

الإتاحة: https://escholarship.org/uc/item/64n63926Test

المؤلفون: Camino, Lola P., Dutta, Arijit, Barroso, Sonia, Pérez-Calero, Carmen, Katz, Jeffrey N., Sung, Patrick, Gómez-González, Belén, Aguilera, Andrés

الوصف: Trabajo presentado en el 2nd Annual Congress of Conexión Cáncer, celebrado en Benidorm (España), del 23 al 25 de enero de 2023

العلاقة: Sí; 2nd Annual Congress of Conexión Cáncer (2023); http://hdl.handle.net/10261/305377Test

الإتاحة: http://hdl.handle.net/10261/305377Test

المؤلفون: Alves, Kristin, Penny, Norgrove, Kobusingye, Olive, Olupot, Robert, Katz, Jeffrey N, Sabatini, Coleen S

المصدر: International Orthopaedics, vol 42, iss 8

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Pediatric, Brain Disorders, Neurosciences, Rehabilitation, Infection, Musculoskeletal, Adolescent, Child, Preschool, Cohort Studies, Cost of Illness, Cross-Sectional Studies, Female, Humans, Infant, Male, Musculoskeletal Diseases, Prevalence, Retrospective Studies, Surveys and Questionnaires, Uganda, Pediatric musculoskeletal health, Pediatric orthopaedics, Gluteal fibrosis, Post-injection paralysis, MSK burden, Orthopedics

الوقت: 1967 - 1973

الوصف: PurposeThe purpose of this study is to estimate the burden of musculoskeletal disease among children treated in Kumi District, Uganda, to inform training, capacity-building efforts, and resource allocation.MethodsWe conducted a retrospective cohort study by reviewing the musculoskeletal (MSK) clinic and community outreach logs for children (age < 18years) seen at Kumi Hospital in Kumi, Uganda, between January 2013 and December 2015. For each patient, we recorded the age, sex, diagnosis, and treatment recommendation.ResultsOf the 4852 children, the most common diagnoses were gluteal and quadriceps contractures (29.4% (95% CI 28.1-30.7%), 96% of which were gluteal fibrosis), post-injection paralysis (12.7% (95% CI 11.8-13.6%)), infection (10.5% (95% CI 9.7-11.4%)), trauma (6.9% (95% CI 6.2-7.6%)), cerebral palsy (6.9% (95% CI 6.2-7.7%)), and clubfoot (4.3% (95% CI 3.8-4.9%)). Gluteal fibrosis, musculoskeletal infections, and angular knee deformities create a large surgical burden with 88.1%, 59.1%, and 54.1% of patients seen with these diagnoses referred for surgery, respectively. Post-injection paralysis, clubfoot, and cerebral palsy were treated non-operatively in over 75% of cases.ConclusionWhile population-based estimates of disease burden and resource utilization are needed, this data offers insight into burden of musculoskeletal disease for this region of Sub-Saharan Africa. We estimate that 50% of the surgical conditions could be prevented with policy changes and education regarding injection practices and early care for traumatic injuries, clubfeet, and infection. This study highlights a need to increase capacity to care for specific musculoskeletal conditions, including gluteal fibrosis, post-injection paralysis, infection, and trauma in the paediatric population of Uganda.

وصف الملف: application/pdf

العلاقة: qt2253879t; https://escholarship.org/uc/item/2253879tTest

الإتاحة: https://escholarship.org/uc/item/2253879tTest

المؤلفون: Alves, Kristin, Penny, Norgrove, Ekure, John, Olupot, Robert, Kobusingye, Olive, Katz, Jeffrey N, Sabatini, Coleen S

المصدر: BMC Musculoskeletal Disorders, vol 19, iss 1

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Research, Pediatric, Prevention, Buttocks, Child, Preschool, Female, Fibrosis, Humans, Injections, Intramuscular, Male, Paralysis, Prevalence, Retrospective Studies, Rural Health, Uganda, Gluteal fibrosis, Post-injection paralysis, Orthopedics, Allied health and rehabilitation science, Sports science and exercise

الوصف: BackgroundThe purpose of this study was to estimate the prevalence of postinjection paralysis (PIP) and gluteal fibrosis (GF) among children treated in a rural Ugandan Hospital.MethodsWe conducted a retrospective cohort study by reviewing the musculoskeletal clinic and community outreach logs for children (age < 18yrs) diagnosed with either PIP or GF from Kumi Hospital in Kumi, Uganda between 2013 and 2015. We estimated the prevalence as a ratio of the number of children seen with each disorder over the total population of children seen for any musculoskeletal complaint in musculoskeletal clinic and total population of children seen for any medical complaint in the outreach clinic.ResultsOf 1513 children seen in the musculoskeletal clinic, 331 (21.9% (95% CI 19.8-24.1%)) had PIP and another 258 (17.1% (95% CI 15.2-19.0%)) had GF as their diagnosis. Of 3339 children seen during outreach for any medical complaint, 283 (8.5% (95% CI 7.6-9.5%)) had PIP and another 1114 (33.4% (95% CI 31.8-35.0%)) had GF. Of patients with GF, 53.9% were male with a median age of 10years (50% between 7 and 12years old). Of patients with PIP, 56.7% were male with a median age of 5years (50% between 2 and 8years old).ConclusionPIP and GF comprise over 30% of clinical visits for musculoskeletal conditions and 40% of outreach visits for any medical complaint in this area of Uganda. The high estimated prevalence in these populations suggest a critical need for research, treatment, and prevention.

وصف الملف: application/pdf

العلاقة: qt82b3m32w; https://escholarship.org/uc/item/82b3m32wTest

الإتاحة: https://escholarship.org/uc/item/82b3m32wTest

المؤلفون: Alves, Kristin, Godwin, Christine L, Chen, Angela, Akellot, Daniella, Katz, Jeffrey N, Sabatini, Coleen S

المصدر: BMC Health Services Research, vol 18, iss 1

مصطلحات موضوعية: Health Services and Systems, Health Sciences, Clinical Research, Prevention, Health Services, 8.1 Organisation and delivery of services, Health and social care services research, Good Health and Well Being, Adult, Attitude of Health Personnel, Buttocks, Child, Delivery of Health Care, Female, Fibrosis, Health Personnel, Humans, Iatrogenic Disease, Injections, Intramuscular, Interviews as Topic, Male, Middle Aged, Motivation, Paralysis, Qualitative Research, Uganda, Gluteal fibrosis, Post-injection paralysis, Injection practices

الوصف: BackgroundIatrogenic injection injury is a major cause of disability in Ugandan children. Two injuries thought to result from injection of medications into the gluteal region include post-injection paralysis (PIP) and gluteal fibrosis (GF). This study aimed to describe perceptions of local health care workers regarding risk factors, particularly injections, for development of GF and PIP. Specifically, we examine the role of injection practices in the development of these injuries by interviewing a diverse cohort of individuals working in the health sector.MethodsWe conducted a qualitative study in the Kumi and Wakiso Districts of Uganda in November 2017, utilizing 68 key informant interviews with individuals working in healthcare related fields. Interviews were structured utilizing a moderator guide focusing on injection practices, gluteal fibrosis and post-injection paralysis.ResultsWe identified six themes regarding perceptions of the cause of GF and PIP and organized these themes into a theoretical framework. There was a consensus among the individuals working in healthcare that inadequacies of the health care delivery system may lead to inappropriate intramuscular injection practices, which are presumed to contribute to the development of GF and PIP. Poor access to medications and qualified personnel has led to the proliferation of private clinics, which are often staffed by under-trained practitioners. Misaligned economic incentives and a lack of training may also motivate practitioners to administer frequent intramuscular injections, which cost more than oral medications. A lack of regulatory enforcement enables these practices to persist. However, due to limited community awareness, patients often perceive these practitioners as appropriately trained, and the patients frequently prefer injections over alternative treatment modalities.ConclusionThis qualitative study suggests that inappropriate intramuscular injections, may arise from problems in the health care delivery system. To prevent the disability ...

وصف الملف: application/pdf

العلاقة: qt3nq1t9sf; https://escholarship.org/uc/item/3nq1t9sfTest

الإتاحة: https://escholarship.org/uc/item/3nq1t9sfTest

المؤلفون: Kraus, Virginia Byers, Collins, Jamie E, Hargrove, David, Losina, Elena, Nevitt, Michael, Katz, Jeffrey N, Wang, Susanne X, Sandell, Linda J, Hoffmann, Steven C, Hunter, David J

المصدر: Annals of the Rheumatic Diseases, vol 76, iss 1

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Aging, Chronic Pain, Pain Research, Arthritis, Clinical Research, Musculoskeletal, Aged, Biomarkers, Case-Control Studies, Disease Progression, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee, Pain Measurement, Predictive Value of Tests, Prognosis, ROC Curve, Radiography, Sensitivity and Specificity, Severity of Illness Index, OA Biomarkers Consortium, Disease Activity, Knee Osteoarthritis, Immunology, Public Health and Health Services

الوصف: ObjectiveTo investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression.MethodsEighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use. For biomarkers with adjusted p<0.1, the c-statistic (area under the curve (AUC)), net reclassification index and the integrated discrimination improvement index were used to further select for hierarchical multivariable discriminative analysis and to determine the most predictive and parsimonious model.ResultsThe 24 M TIC of eight biomarkers significantly predicted case status (ORs per 1 SD change in biomarker): sCTXI 1.28, sHA 1.22, sNTXI 1.25, uC2C-HUSA 1.27, uCTXII, 1.37, uNTXI 1.29, uCTXIα 1.32, uCTXIβ 1.27. 24 M TIC of uCTXII (1.47-1.72) and uC2C-Human Urine Sandwich Assay (HUSA) (1.36-1.50) both predicted individual group status (pain worsening, joint space loss and their combination). The most predictive and parsimonious combinatorial model for case status consisted of 24 M TIC uCTXII, sHA and sNTXI (AUC 0.667 adjusted). Baseline uCTXII and uCTXIα both significantly predicted case status (OR 1.29 and 1.20, respectively).ConclusionsSeveral systemic candidate biomarkers hold promise as predictors of pain and structural worsening of OA.

وصف الملف: application/pdf

العلاقة: qt18b9038b; https://escholarship.org/uc/item/18b9038bTest

الإتاحة: https://escholarship.org/uc/item/18b9038bTest

المؤلفون: Isaac, Zacharia, Katz, Jeffrey N.

المصدر: Rheumatology ; page 578-594 ; ISBN 9780323091381

الإتاحة: https://doi.org/10.1016/b978-0-323-09138-1.00072-3Test
https://api.elsevier.com/content/article/PII:B9780323091381000723?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:B9780323091381000723?httpAccept=text/plainTest

المؤلفون: Power, J. Denise, Katz, Jeffrey N., Perruccio, Anthony V.

المصدر: Encyclopedia of Quality of Life and Well-Being Research ; page 1-6 ; ISBN 9783319699097 9783319699097

الإتاحة: https://doi.org/10.1007/978-3-319-69909-7_1878-2Test