التفاصيل البيبلوغرافية
| العنوان: |
Table_1_The Human Milk Oligosaccharide 2′-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice.DOCX |
| المؤلفون: |
Eveline Gart, Kanita Salic, Martine C. Morrison, Martin Giera, Joline Attema, Christa de Ruiter, Martien Caspers, Frank Schuren, Ivana Bobeldijk-Pastorova, Marianne Heer, Yan Qin, Robert Kleemann |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Clinical and Sports Nutrition, Dietetics and Nutrigenomics, Nutritional Physiology, Public Nutrition Intervention, Nutrition and Dietetics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Food Nutritional Balance, Animal Nutrition, Crop and Pasture Nutrition, human milk oligosaccharides, prebiotics, non-alcoholic fatty liver disease, diacylglycerols, insulin resistance, obesity, gut permeability |
| الوصف: |
Non-alcoholic fatty liver disease (NAFLD) is a complex multifactorial disorder that is associated with gut dysbiosis, enhanced gut permeability, adiposity and insulin resistance. Prebiotics such as human milk oligosaccharide 2′-fucosyllactose are thought to primarily improve gut health and it is uncertain whether they would affect more distant organs. This study investigates whether 2′-fucosyllactose can alleviate NAFLD development in manifest obesity. Obese hyperinsulinemic Ldlr-/-.Leiden mice, after an 8 week run-in on a high-fat diet (HFD), were treated with 2′-fucosyllactose by oral gavage until week 28 and compared to HFD-vehicle controls. 2′-fucosyllactose did not affect food intake, body weight, total fat mass or plasma lipids. 2′-fucosyllactose altered the fecal microbiota composition which was paralleled by a suppression of HFD-induced gut permeability at t = 12 weeks. 2′-fucosyllactose significantly attenuated the development of NAFLD by reducing microvesicular steatosis. These hepatoprotective effects were supported by upstream regulator analyses showing that 2′-fucosyllactose activated ACOX1 (involved in lipid catabolism), while deactivating SREBF1 (involved in lipogenesis). Furthermore, 2′-fucosyllactose suppressed ATF4, ATF6, ERN1, and NUPR1 all of which participate in endoplasmic reticulum stress. 2′-fucosyllactose reduced fasting insulin concentrations and HOMA-IR, which was corroborated by decreased intrahepatic diacylglycerols. In conclusion, long-term supplementation with 2′-fucosyllactose can counteract the detrimental effects of HFD on gut dysbiosis and gut permeability and attenuates the development of liver steatosis. The observed reduction in intrahepatic diacylglycerols provides a mechanistic rationale for the improvement of hyperinsulinemia and supports the use of 2′-fucosyllactose to correct dysmetabolism and insulin resistance. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_The_Human_Milk_Oligosaccharide_2_-Fucosyllactose_Alleviates_Liver_Steatosis_ER_Stress_and_Insulin_Resistance_by_Reducing_Hepatic_Diacylglycerols_and_Improved_Gut_Permeability_in_Obese_Ldlr-_-_Leiden_Mice_DOCX/20089367Test |
| DOI: |
10.3389/fnut.2022.904740.s001 |
| الإتاحة: |
https://doi.org/10.3389/fnut.2022.904740.s001Test
https://figshare.com/articles/dataset/Table_1_The_Human_Milk_Oligosaccharide_2_-Fucosyllactose_Alleviates_Liver_Steatosis_ER_Stress_and_Insulin_Resistance_by_Reducing_Hepatic_Diacylglycerols_and_Improved_Gut_Permeability_in_Obese_Ldlr-_-_Leiden_Mice_DOCX/20089367Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.FF359240 |
| قاعدة البيانات: |
BASE |
