المؤلفون: Russell, Steven, Beck, Roy, Damiano, Edward, El-Khatib, Firas, Ruedy, Katrina, Balliro, Courtney, Li, Zoey, Calhoun, Peter, Wadwa, R, Buckingham, Bruce, Zhou, Keren, Daniels, Mark, Raskin, Philip, White, Perrin, Lynch, Jane, Pettus, Jeremy, Hirsch, Irl, Goland, Robin, Buse, John, Kruger, Davida, Mauras, Nelly, Muir, Andrew, McGill, Janet, Cogen, Fran, Weissberg-Benchell, Jill, Sherwood, Jordan, Castellanos, Luz, Hillard, Mallory, Tuffaha, Marwa, Putman, Melissa, Sands, Mollie, Forlenza, Gregory, Slover, Robert, Messer, Laurel, Cobry, Erin, Shah, Viral, Polsky, Sarit, Lal, Rayhan, Ekhlaspour, Laya, Hughes, Michael, Basina, Marina, Hatipoglu, Betul, Olansky, Leann, Bhangoo, Amrit, Forghani, Nikta, Kashmiri, Himala, Sutton, Francoise, Choudhary, Abha, Penn, Jimmy, Jafri, Rabab, Rayas, Maria, Escaname, Elia, Kerr, Catherine, Favela-Prezas, Ruby, Trikudanathan, Subbulaxmi, Williams, Kristen, Leibel, Natasha, Kirkman, M, Bergamo, Kate, Klein, Klara, Dostou, Jean, Machineni, Sriram, Young, Laura, Diner, Jamie, Bhan, Arti, Jones, J, Benson, Matthew, Bird, Keisha, Englert, Kimberly, Permuy, Joe, Cossen, Kristina, Felner, Eric, Salam, Maamoun, Silverstein, Julie, Adamson, Samantha, Cedeno, Andrea, Meighan, Seema, Dauber, Andrew, Boeder, Schafer

المصدر: The New England Journal of Medicine, vol 387, iss 13

مصطلحات موضوعية: Adolescent, Adult, Aged, Bionics, Blood Glucose, Blood Glucose Self-Monitoring, Child, Diabetes Mellitus, Type 1, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Insulin Aspart, Insulin Infusion Systems, Insulin Lispro, Middle Aged, Young Adult

الوصف: BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring). The primary outcome was the glycated hemoglobin level at 13 weeks. The key secondary outcome was the percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter; the prespecified noninferiority limit for this outcome was 1 percentage point. Safety was also assessed. RESULTS: A total of 219 participants 6 to 79 years of age were assigned to the bionic-pancreas group, and 107 to the standard-care group. The glycated hemoglobin level decreased from 7.9% to 7.3% in the bionic-pancreas group and did not change (was at 7.7% at both time points) in the standard-care group (mean adjusted difference at 13 weeks, -0.5 percentage points; 95% confidence interval [CI], -0.6 to -0.3; P<0.001). The percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter did not differ significantly between the two groups (13-week adjusted difference, 0.0 percentage points; 95% CI, -0.1 to 0.04; P<0.001 for noninferiority). The rate of severe hypoglycemia was 17.7 events per 100 participant-years in the bionic-pancreas group and 10.8 events per 100 participant-years in the standard-care group (P = 0.39). No episodes of diabetic ketoacidosis occurred in either group. ...

وصف الملف: application/pdf

العلاقة: qt1m5021wb; https://escholarship.org/uc/item/1m5021wbTest

الإتاحة: https://escholarship.org/uc/item/1m5021wbTest

المؤلفون: Ali, Khawla F., Hatipoglu, Betul

المصدر: OBM Transplantation ; volume 4, issue 3, page 1-9

الإتاحة: https://doi.org/10.21926/obm.transplant.2003115Test

المؤلفون: Ali, Khawla F., Martin, Vicente T. San, Stevens, Tyler, Walsh, R. Matthew, Bottino, Rita, Trucco, Massimo, Hatipoglu, Betul

المصدر: OBM Transplantation ; volume 2, issue 3, page 1-1 ; ISSN 2577-5820

الإتاحة: https://doi.org/10.21926/obm.transplant.1803014Test

المؤلفون: Russell, Steven J, Beck, Roy W, Damiano, Edward R, El-Khatib, Firas H, Ruedy, Katrina J, Balliro, Courtney A, Li, Zoey, Calhoun, Peter, Wadwa, R. Paul, Buckingham, Bruce, Zhou, Keren, Daniels, Mark, Raskin, Philip, White, Perrin C, Lynch, Jane, Pettus, Jeremy, Hirsch, Irl B, Goland, Robin, Buse, John B, Kruger, Davida F, Mauras, Nelly, Muir, Andrew, McGill, Janet B, Cogen, Fran, Weissberg-Benchell, Jill, Sherwood, Jordan S, Castellanos, Luz E, Hillard, Mallory A, Tuffaha, Marwa, Putman, Melissa S, Sands, Mollie Y, Forlenza, Gregory, Slover, Robert, Messer, Laurel H, Cobry, Erin, Shah, Viral N, Polsky, Sarit, Lal, Rayhan, Ekhlaspour, Laya, Hughes, Michael S, Basina, Marina, Hatipoglu, Betul, Olansky, Leann, Bhangoo, Amrit, Forghani, Nikta, Kashmiri, Himala, Sutton, Francoise, Choudhary, Abha, Penn, Jimmy, Jafri, Rabab, Rayas, Maria, Escaname, Elia, Kerr, Catherine, Favela-Prezas, Ruby, Boeder, Schafer, Trikudanathan, Subbulaxmi, Williams, Kristen M, Leibel, Natasha, Kirkman, M. Sue, Bergamo, Kate, Klein, Klara R, Dostou, Jean M, Machineni, Sriram, Young, Laura A, Diner, Jamie C, Bhan, Arti, Jones, J. Kimberly, Benson, Matthew, Bird, Keisha, Englert, Kimberly, Permuy, Joe, Cossen, Kristina, Felner, Eric, Salam, Maamoun, Silverstein, Julie M, Adamson, Samantha, Cedeno, Andrea, Meighan, Seema, Dauber, Andrew

المصدر: Endocrinology Articles

مصطلحات موضوعية: Adolescent, Adult, Aged, Bionics, Blood Glucose, Blood Glucose Self-Monitoring, Child, Diabetes Mellitus, Type 1, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Insulin, Insulin Aspart, Insulin Infusion Systems, Insulin Lispro, Middle Aged, Young Adult

الوصف: BACKGROUND: Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting. METHODS: In this 13-week, multicenter, randomized trial, we randomly assigned in a 2:1 ratio persons at least 6 years of age with type 1 diabetes either to receive bionic pancreas treatment with insulin aspart or insulin lispro or to receive standard care (defined as any insulin-delivery method with unblinded, real-time continuous glucose monitoring). The primary outcome was the glycated hemoglobin level at 13 weeks. The key secondary outcome was the percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter; the prespecified noninferiority limit for this outcome was 1 percentage point. Safety was also assessed. RESULTS: A total of 219 participants 6 to 79 years of age were assigned to the bionic-pancreas group, and 107 to the standard-care group. The glycated hemoglobin level decreased from 7.9% to 7.3% in the bionic-pancreas group and did not change (was at 7.7% at both time points) in the standard-care group (mean adjusted difference at 13 weeks, -0.5 percentage points; 95% confidence interval [CI], -0.6 to -0.3; P<0.001). The percentage of time that the glucose level as assessed by continuous glucose monitoring was below 54 mg per deciliter did not differ significantly between the two groups (13-week adjusted difference, 0.0 percentage points; 95% CI, -0.1 to 0.04; P<0.001 for noninferiority). The rate of severe hypoglycemia was 17.7 events per 100 participant-years in the bionic-pancreas group and 10.8 events per 100 participant-years in the standard-care group (P = 0.39). No episodes of diabetic ketoacidosis occurred in either group. ...

العلاقة: https://scholarlycommons.henryford.com/endocrinology_articles/129Test; https://libkey.io/36170500Test

الإتاحة: https://scholarlycommons.henryford.com/endocrinology_articles/129Test
https://libkey.io/36170500Test

المؤلفون: Pivonello, Rosario, Hatipoglu, Betul, Bertagna, Xavier, Fleseriu, Maria, Molitch, Mark E, Shimizu, Chikara, Tanaka, Tomoaki, Shimatsu, Akira, Biller, Beverly M K, Ravichandran, Shoba, Kandra, Albert, Sauter, Nicholas, Young, Jacques

المصدر: Endocrine Abstracts ; ISSN 1479-6848

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1530/endoabs.41.ep887Test
http://www.endocrine-abstracts.org/ea/0041/ea0041EP887.htmTest

المؤلفون: Bancos, Irina, Hatipoglu, Betul Ayse, Yuen, Kevin C J, Chandramohan, Lakshmi, Chaudhari, Sandeep, Moraitis, Andreas G

المصدر: Articles, Abstracts, and Reports

مصطلحات موضوعية: genomics, washington, seattle, swedish neuro, Endocrinology, Diabetes, and Metabolism, Neurosciences, Surgery

الوصف: Purpose: To evaluate the performance of FKBP5 as a cortisol activity biomarker in patients with ACTH-dependent Cushing syndrome (CS). Methods: This was a prospective, multicenter, nonrandomized, noninterventional study of a cortisol activity biomarker in adult patients (≥18 years) with documented ACTH-dependent, endogenous CS. The impact of surgery on FKBP5 mRNA expression levels in these patients and the difference in expression levels between these patients and healthy controls were evaluated. Cortisol and biomarker samples were collected before and immediately after surgery. A custom NanoString assay was used to quantify FKBP5 mRNA expression levels. The same method was used to analyze healthy volunteer samples collected from a different study. Results: Surgery was considered successful in 14/24 patients (58.3%) and changes from baseline in serum cortisol were -92.6% ( Conclusions: Our findings confirm that FKBP5 levels are higher in the presence of excess cortisol exposure in patients with CS and decrease to normal baseline levels after successful surgery. These findings suggest that FKBP5 can serve as a measure of biological cortisol activity and set the stage for the development of an FKBP5 mRNA expression assay as a biomarker of cortisol activity.

العلاقة: https://digitalcommons.psjhealth.org/publications/5065Test; https://pubmed.ncbi.nlm.nih.gov/34258233Test/

الإتاحة: https://digitalcommons.psjhealth.org/publications/5065Test
https://pubmed.ncbi.nlm.nih.gov/34258233Test/

المؤلفون: Johnston, Philip C, Lin, Yu, Walsh, Matthew, Stevens, Tyler, Bottino, Rita, Trucco, Massimo, Bena, James, Hatipoglu, Betul

المصدر: Endocrine Abstracts ; ISSN 1479-6848

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1530/endoabs.37.gp.14.08Test
http://www.endocrine-abstracts.org/ea/0037/ea0037GP.14.08.htmTest