نتائج البحث - "Ferraccioli, Gianfranco"

1

دورية أكاديمية

The forgotten key players in rheumatoid arthritis: IL-8 and IL-17 – Unmet needs and therapeutic perspectives

المؤلفون: Gremese, Elisa, Tolusso, Barbara, Bruno, Dario, Perniola, Simone, Ferraccioli, Gianfranco, Alivernini, Stefano

المصدر: Frontiers in Medicine ; volume 10 ; ISSN 2296-858X

الوصف: Despite the relevant advances in our understanding of the pathogenetic mechanisms regulating inflammation in rheumatoid arthritis (RA) and the development of effective therapeutics, to date, there is still a proportion of patients with RA who do not respond to treatment and end up progressing toward the development of joint damage, extra-articular complications, and disability. This is mainly due to the inter-individual heterogeneity of the molecular and cellular taxonomy of the synovial membrane, which represents the target tissue of RA inflammation. Tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) are crucial key players in RA pathogenesis fueling the inflammatory cascade, as supported by experimental evidence derived from in vivo animal models and the effectiveness of biologic-Disease Modifying Anti-Rheumatic Drugs (b-DMARDs) in patients with RA. However, additional inflammatory soluble mediators such as IL-8 and IL-17 exert their pathogenetic actions promoting the detrimental activation of immune and stromal cells in RA synovial membrane, tendons, and extra-articular sites, as well as blood vessels and lungs, causing extra-articular complications, which might be excluded by the action of anti-TNFα and anti-IL6R targeted therapies. In this narrative review, we will discuss the role of IL-8 and IL-17 in promoting inflammation in multiple biological compartments (i.e., synovial membrane, blood vessels, and lung, respectively) in animal models of arthritis and patients with RA and how their selective targeting could improve the management of treatment resistance in patients.

الإتاحة: https://doi.org/10.3389/fmed.2023.956127Test

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2

مؤتمر

P189 Antiphospholipid antibodies and vascular renal lesions as prognostic factors in lupus nephritis

المؤلفون: Paglionico, Annamaria, Varriano, Valentina, Petricca, Luca, Marioa, Clara Di, Gigante, Maria Rita, Tanti, Giacomo, Tolusso, Barbara, Ferraccioli, Gianfranco, Gremese, Elisa

المصدر: Poster presentations

الإتاحة: https://doi.org/10.1136/lupus-2020-eurolupus.231Test

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3

مؤتمر

P189â€…Antiphospholipid antibodies and vascular renal lesions as prognostic factors in lupus nephritis

المؤلفون: Paglionico, Annamaria, Varriano, Valentina, Petricca, Luca, Marioa, Clara Di, Gigante, Maria Rita, Tanti, Giacomo, Tolusso, Barbara, Ferraccioli, Gianfranco, Gremese, Elisa

الوصف: n/a

العلاقة: url:https://www.openaccessrepository.it/communities/itmirrorTest; https://www.openaccessrepository.it/record/160430Test

الإتاحة: https://doi.org/10.1136/lupus-2020-eurolupus.231Test
https://www.openaccessrepository.it/record/160430Test

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4

دورية أكاديمية

Haemophilus parasuis (Glaesserella parasuis) as a Potential Driver of Molecular Mimicry and Inflammation in Rheumatoid Arthritis

المؤلفون: Di Sante, Gabriele, Gremese, Elisa, Tolusso, Barbara, Cattani, Paola, Di Mario, Clara, Marchetti, Simona, Alivernini, Stefano, Tredicine, Maria, Petricca, Luca, Palucci, Ivana, Camponeschi, Chiara, Aragon, Virginia, Gambotto, Andrea, Ria, Francesco, Ferraccioli, Gianfranco

المساهمون: Fondazione Italiana Sclerosi Multipla, Università Cattolica del Sacro Cuore

المصدر: Frontiers in Medicine ; volume 8 ; ISSN 2296-858X

الوصف: Background: Haemophilus parasuis ( Hps ; now Glaesserella parasuis ) is an infectious agent that causes severe arthritis in swines and shares sequence similarity with residues 261–273 of collagen type 2 (Coll 261−273 ), a possible autoantigen in rheumatoid arthritis (RA). Objectives/methods: We tested the presence of Hps sequencing 16S ribosomal RNA in crevicular fluid, synovial fluids, and tissues in patients with arthritis (RA and other peripheral arthritides) and in healthy controls. Moreover, we examined the cross-recognition of Hps by Coll 261−273 -specific T cells in HLA-DRB1 * 04 pos RA patients, by T-cell receptor (TCR) beta chain spectratyping and T-cell phenotyping. Results: Hps DNA was present in 57.4% of the tooth crevicular fluids of RA patients and in 31.6% of controls. Anti- Hps IgM and IgG titers were detectable and correlated with disease duration and the age of the patients. Peripheral blood mononuclear cells (PBMCs) were stimulated with Hps virulence-associated trimeric autotransporter peptide (VtaA10 755−766 ), homologous to human Coll 261−273 or co-cultured with live Hps . In both conditions, the expanded TCR repertoire overlapped with Coll 261−273 and led to the production of IL-17. Discussion: We show that the DNA of an infectious agent ( Hps ), not previously described as pathogen in humans, is present in most patients with RA and that an Hps peptide is able to activate T cells specific for Coll 261−273 , likely inducing or maintaining a molecular mimicry mechanism. Conclusion: The cross-reactivity between VtaA10 755−766 of a non-human infectious agent and human Coll 261−273 suggests an involvement in the pathogenesis of RA. This mechanism appears emphasized in predisposed individuals, such as patients with shared epitope.

الإتاحة: https://doi.org/10.3389/fmed.2021.671018Test

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5

دورية أكاديمية

Systemic Bone Density at Disease Onset Is Associated With Joint Erosion Progression in Early Naive to Treatment Rheumatoid Arthritis: A Prospective 12-Month Follow-Up Open-Label Study

المؤلفون: Bruno, Dario, Fedele, Anna Laura, Tolusso, Barbara, Barini, Angelina, Petricca, Luca, Di Mario, Clara, Barini, Antonella, Mirone, Luisa, Ferraccioli, Gianfranco, Alivernini, Stefano, Gremese, Elisa

المصدر: Frontiers in Medicine ; volume 8 ; ISSN 2296-858X

مصطلحات موضوعية: General Medicine

الوصف: Objectives: Osteoporosis and bone erosions are hallmarks of rheumatoid arthritis (RA) since disease onset is underpinned by the inflammatory burden. In this observational study, we aimed to dissect the putative RA-related parameters and bone-derived biomarkers associated with systemic and focal bone loss at disease onset and with their progression. Methods: One-hundred twenty-eight patients with early rheumatoid arthritis (ERA) were recruited at disease onset. At study entry, demographic, clinical, and immunological parameters were recorded. Each ERA patient underwent plain X-rays of the hands and feet at study entry and after 12 months to assess the presence of erosions. After enrollment, each patient was treated according to the recommendations for RA management and followed up based on a treat-to-target (T2T) strategy. At baseline, blood samples for soluble biomarkers were collected from each patient, and plasma levels of osteoprotegerin (OPG), receptor activator of nuclear factor κB ligand (RANKL), Dickkopf-1 (DKK1), and interleukin 6 (IL-6) were assessed by enzyme-linked immunosorbent assay (ELISA). Seventy-one ERA patients underwent bone mineral density (BMD) measurement at the left femoral neck and second to fourth lumbar spine vertebrae (L2–L4) by dual-energy X-ray absorptiometry (DXA). Results: Among the whole cohort, 34 (26.6%) ERA patients with bone erosions at study entry had a higher disease activity ( p = 0.02) and IL-6 plasma levels ( p = 0.03) than non-erosive ones. Moreover, at DXA, 33 (46.5%) ERA patients had osteopenia, and 16 (22.5%) had osteoporosis; patients with baseline bone erosions were more likely osteopenic/osteoporotic than non-erosive ones ( p = 0.03), regardless of OPG, RANKL, and DKK1 plasma levels. Obese ERA patients were less likely osteopenic/osteoporotic than normal weight ones ( p = 0.002), whereas anti-citrullinated protein antibodies (ACPA) positive ERA patients were more likely osteopenic/osteoporotic than ACPA negative ones ( p = 0.034). At logistic regression analysis, ...

الإتاحة: https://doi.org/10.3389/fmed.2021.613889Test

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