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1دورية أكاديمية
المؤلفون: Edwina Brennan, Alexandra Butler, Manjula Nandakumar, Kristie Thompson, Thozhukat Sathyapalan, Stephen Atkin
مصطلحات موضوعية: Endocrinology, Bisphenols, Cholecalciferol, Endocrine disrupting chemicals (EDCs), Endocrine disrupting chemicals, Phthalate metabolites, Plasticizers, Vitamin D(3), Vitamin D, Endocrine Disruptors, female
الوصف: Introduction: Evidence suggests that endocrine disrupting chemicals (EDCs), commonly used in plastics and personal care products, may be associated with reduced levels of vitamin D. Therefore, this study examined the relationship between phthalate metabolites, 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan; TCS) and bisphenols (BPs) with vitamin D3 (25(OH)D3) and active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and their relationship to calcium homeostasis. Methods: 57 female participants (age 31.8 ± 4.6 years; BMI 25.6 ± 3.7 kg/m2) were analyzed for urinary levels of phthalate metabolites, TCS and BPs, and serum levels of 25(OH)D3 and 1,25(OH)2D3, determined by isotope-dilution liquid chromatography tandem mass spectrometry. Serum calcium/calmodulin-dependent (CaM) associated proteins were determined by Slow Off-rate Modified Aptamer (SOMA)-scan. Results: In the study cohort, 25(OH)D3 and 1,25(OH)2D3 levels were 22.9 ± 11.2 ng/mL and 0.05 ± 0.02 ng/mL, respectively: mono-3-carboxypropyl-phthalate (MCPP) correlated negatively with 25(OH)D3 (ρ = -0.53, p = 0.01). 28 of the 57 women recruited were 25(OH)D3 deficient, <20 ng/mL (50 nmol/L): in this group, mono-iso-butylphthalate (MiBP) and mono-butylphthalate (MBP) negatively correlated with 25(OH)D3; (ρ = -0.47, p = 0.049) and (ρ = -0.64, p = 0.005), respectively. EDCs did not correlate with 1,25(OH)2D3, measures of renal function or CaM proteins. Conclusion: These putative data indicate that MCPP is related to 25(OH)D3, while MiBP and MBP were related to vitamin D deficiency; however, no correlations were observed with TCS and BPs. No phthalate metabolites correlated with 1,25(OH)2D3, CaM associated proteins or renal function, suggesting that effects occur earlier in the vitamin D pathway and not through modulation of cellular calcium flux. The observed correlations are surprisingly strong compared to other predictors of 25(OH)D3, and larger studies adjusting for potential confounders are warranted.
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2دورية أكاديمية
المؤلفون: Brennan, Edwina, Butler, Alexandra E., Nandakumar, Manjula, Thompson, Kristie, Sathyapalan, Thozhukat, Atkin, Stephen L.
مصطلحات موضوعية: Endocrine disrupting chemicals (EDCs), Phthalate metabolites, Bisphenols, Plasticizers, Vitamin D3, Cholecalciferol
الوصف: Introduction: Evidence suggests that endocrine disrupting chemicals (EDCs), commonly used in plastics and personal care products, may be associated with reduced levels of vitamin D. Therefore, this study examined the relationship between phthalate metabolites, 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan; TCS) and bisphenols (BPs) with vitamin D3 (25(OH)D3) and active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), and their relationship to calcium homeostasis. Methods: 57 female participants (age 31.8 ± 4.6 years; BMI 25.6 ± 3.7 kg/m2) were analyzed for urinary levels of phthalate metabolites, TCS and BPs, and serum levels of 25(OH)D3 and 1,25(OH)2D3, determined by isotope-dilution liquid chromatography tandem mass spectrometry. Serum calcium/calmodulin-dependent (CaM) associated proteins were determined by Slow Off-rate Modified Aptamer (SOMA)-scan. Results: In the study cohort, 25(OH)D3 and 1,25(OH)2D3 levels were 22.9 ± 11.2 ng/mL and 0.05 ± 0.02 ng/mL, respectively: mono-3-carboxypropyl-phthalate (MCPP) correlated negatively with 25(OH)D3 (ρ = −0.53, p = 0.01). 28 of the 57 women recruited were 25(OH)D3 deficient, <20 ng/mL (50 nmol/L): in this group, mono-iso-butylphthalate (MiBP) and mono-butylphthalate (MBP) negatively correlated with 25(OH)D3; (ρ = −0.47, p = 0.049) and (ρ = −0.64, p = 0.005), respectively. EDCs did not correlate with 1,25(OH)2D3, measures of renal function or CaM proteins. Conclusion: These putative data indicate that MCPP is related to 25(OH)D3, while MiBP and MBP were related to vitamin D deficiency; however, no correlations were observed with TCS and BPs. No phthalate metabolites correlated with 1,25(OH)2D3, CaM associated proteins or renal function, suggesting that effects occur earlier in the vitamin D pathway and not through modulation of cellular calcium flux. The observed correlations are surprisingly strong compared to other predictors of 25(OH)D3, and larger studies adjusting for potential confounders are warranted.
العلاقة: https://hull-repository.worktribe.com/output/4493716Test; Chemosphere; Volume 349; https://hull-repository.worktribe.com/file/4493716/1/Published%20articleTest
الإتاحة: https://doi.org/10.1016/j.chemosphere.2023.140894Test
https://hull-repository.worktribe.com/file/4493716/1/Published%20articleTest
https://hull-repository.worktribe.com/output/4493716Test -
3دورية أكاديمية
المؤلفون: Veselá, Lenka
المصدر: Matter: Journal of New Materialist Research; Núm. 7 (2023): Situar la recerca sobre art, pràctiques tecnològiques i literatura; 47-68 ; 2604-7551
مصطلحات موضوعية: Substàncies químiques alteradores endocrines, Exposicions químiques, Emocions, Antropocè, Tecnociència feminista, Endocrine-Disrupting Chemicals, Chemical Exposures, Anthropocene, Feminist Technoscience
الوصف: Les substàncies químiques alteradores endocrines són composts fabricats industrialment que tenen la capacitat d'imitar o interferir en la biosíntesi, el metabolisme i les funcions de les hormones produïdes per l'organisme. La ubiqüitat i persistència de les substàncies químiques alteradores endocrines en el medi ambient han suscitat preocupació pel seu impacte en la vida humana i no humana. Com ens afecten aquestes substàncies químiques? Com interactuem amb elles? I com responem als riscos que plantegen? La meva recerca sobre com ens afecten els alteradors endocrins químics se centra en com poden influir en les nostres emocions. Atenc a com l'exposició a ells pot alterar la nostra química cerebral i, per tant, també les nostres emocions. Amb l'ajuda de l'eina Endocrine Disruption Tracker - un instrument especulatiu per a una pràctica de recerca col·lectiva que he creat- examino el que podem aprendre sobre l'alteració endocrina si considerem com es veuen afectades les nostres emocions. He desenvolupat aquesta eina per a ajudar-me a mi, als participants en la meva recerca i a una comunitat més àmplia de persones interessades a abordar les exigències de les nostres vides, afectades per l'exposició involuntària a substàncies químiques, i a construir relacions de cura receptives, aplanant el camí per a nous enfocaments de la recerca, l'ètica i la política que estiguin encarnats, basats en l'experiència i el material, en les seves preocupacions sobre les substàncies químiques que alteren el sistema endocrí. ; Endocrine-disrupting chemicals are industrially manufactured compounds that have the capacity to mimic or interfere with biosynthesis, metabolism, and the functions of bodily produced hormones. The ubiquity and persistence of endocrine-disrupting chemicals in the environment have raised concerns about their impacts on human as well as nonhuman life. How do these chemicals affect us? How do we interact with them? And how do we respond to the risks that they pose? My inquiry into how chemical endocrine disruptors ...
العلاقة: http://www.raco.cat/index.php/Matter/article/view/413659/508528Test; http://www.raco.cat/index.php/Matter/article/view/413659Test
الإتاحة: https://doi.org/10.1344/jnmr.v7i1.42250Test
http://www.raco.cat/index.php/Matter/article/view/413659Test -
4دورية أكاديمية
المؤلفون: V. Swarupa, Preeti Karki, K.M. Abdullah, Niveditha Nittoor, Pragathi Reddy, Raksha P, Rekha Mirle
المصدر: JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH; Vol. 5 No. 5 (2023): JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH-ISENTIENT-2022 ; 2454-3225
مصطلحات موضوعية: Steroidogenesis, Sex Hormones, Sexual Orientation, Endocrine-disrupting chemicals (EDCs)
الوصف: Gonadal steroids are crucial hormones responsible for the proper functioning and growth of the body. The sex hormones are produced in the adrenal glands and gonads by a process called steroidogenesis. Steroidogenesis is an enzymatic reaction where cholesterol gets converted to active steroid hormones in the respective gonads and play a dominant role in determining the primary and secondary characteristics of organisms. Studies has revealed that highly divergent groups of xenobiotic compounds are known to obstruct with steroidogenesis and cause endocrine-disrupting effects. Environmental contaminants such as DDT and PCBs are known to affect steroidogenesis. Chemicals such as azole fungicides and antifungal drugs is known to function as powerful inhibitors of steroidogenic enzymes, resulting in endocrine disruption. With the increasing various hormonal disorders and decreased fertility rate due to stress and improper lifestyle, understanding the role and environmental impact of sex hormones on humans helps to manage and lead a healthy life. This review highlights the biosynthesis, functional mechanism of estrogen, progesterone and testosterone hormones including the effects of its varying levels and the influence of endocrine disrupting compounds (EDCs) on the steroidogenesis process.
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5دورية أكاديمية
المؤلفون: RE Foong, P Franklin, F Sanna, GL Hall, PD Sly, EB Thorstensen, DA Doherty, JA Keelan, RJ Hart
مصطلحات موضوعية: ALLERGIC DISEASES, asthma, ATOPY, BISPHENOL-A EXPOSURE, CHILDREN, ENDOCRINE-DISRUPTING CHEMICALS, environmental exposure, Life Sciences & Biomedicine, longitudinal birth cohort study, lung function, pregnancy, Respiratory System, Science & Technology, the Raine study
الوصف: Longitudinal effects of prenatal exposure to plastic-derived chemicals and their metabolites on asthma and lung function from childhood into adulthood
العلاقة: http://hdl.handle.net/10779/DRO/DU:22066916.v3Test; https://figshare.com/articles/journal_contribution/Longitudinal_effects_of_prenatal_exposure_to_plastic-derived_chemicals_and_their_metabolites_on_asthma_and_lung_function_from_childhood_into_adulthood/22066916Test
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6دورية أكاديمية
المؤلفون: Tapia, Jazma L., McDonough, Jillian C., Cauble, Emily L., Gonzalez, Cesar G., Teteh, Dede K., Treviño, Lindsey S.
المصدر: Health Sciences and Kinesiology Faculty Articles
مصطلحات موضوعية: breast cancer, endocrine disrupting chemicals, parabens, health disparities, Cancer Biology, Chemical Actions and Uses, Medicine and Health, Oncology, Other Chemicals and Drugs, Race and Ethnicity, Women's Health
الوصف: Context One in 8 women will develop breast cancer in their lifetime. Yet, the burden of disease is greater in Black women. Black women have a 40% higher mortality rate than White women, and a higher incidence of breast cancer at age 40 and younger. While the underlying cause of this disparity is multifactorial, exposure to endocrine disrupting chemicals (EDCs) in hair and other personal care products has been associated with an increased risk of breast cancer. Parabens are known EDCs that are commonly used as preservatives in hair and other personal care products, and Black women are disproportionately exposed to products containing parabens. Objective Studies have shown that parabens impact breast cancer cell proliferation, death, migration/invasion, and metabolism, as well as gene expression in vitro. However, these studies were conducted using cell lines of European ancestry; to date, no studies have utilized breast cancer cell lines of West African ancestry to examine the effects of parabens on breast cancer progression. Like breast cancer cell lines with European ancestry, we hypothesize that parabens promote protumorigenic effects in breast cancer cell lines of West African ancestry. Methods Luminal breast cancer cell lines with West African ancestry (HCC1500) and European ancestry (MCF-7) were treated with biologically relevant doses of methylparaben, propylparaben, and butylparaben. Results Following treatment, estrogen receptor target gene expression and cell viability were examined. We observed altered estrogen receptor target gene expression and cell viability that was paraben and cell line specific. Conclusion This study provides greater insight into the tumorigenic role of parabens in the progression of breast cancer in Black women.
وصف الملف: application/pdf
العلاقة: https://digitalcommons.chapman.edu/health_sciences_articles/29Test; https://digitalcommons.chapman.edu/context/health_sciences_articles/article/1029/viewcontent/Parabens_Promote_Protumorigenic_Effects_in_Luminal_Breast_Cancer_Cell_Lines_With_Diverse_Genetic_Ancestry.pdfTest
الإتاحة: https://doi.org/10.1210/jendso/bvad080Test
https://digitalcommons.chapman.edu/health_sciences_articles/29Test
https://digitalcommons.chapman.edu/context/health_sciences_articles/article/1029/viewcontent/Parabens_Promote_Protumorigenic_Effects_in_Luminal_Breast_Cancer_Cell_Lines_With_Diverse_Genetic_Ancestry.pdfTest -
7دورية أكاديمية
المؤلفون: Cunha, Yandra Giovanna de Oliveira, do Amaral, Giovanna Cavalcanti Brito, Felix, Alana Almeida, Blumberg, Bruce, Amato, Angelica Amorim
مصطلحات موضوعية: Humans, Prenatal Exposure Delayed Effects, Pesticides, Epidemiologic Studies, Autistic Disorder, Pregnancy, Adolescent, Child, Preschool, Female, Endocrine Disruptors, Autism Spectrum Disorder, autistic traits, endocrine-disrupting chemicals, neurodevelopment, Neurosciences, Intellectual and Developmental Disabilities (IDD), Pediatric, Autism, Mental Health, Pediatric Research Initiative, Estrogen, Brain Disorders, 2.3 Psychological, social and economic factors, Aetiology, Clinical Sciences, Nutrition and Dietetics
الوصف: AimsExposure to endocrine-disrupting chemicals (EDCs) during critical neurodevelopmental windows has been associated with the risk of autistic traits. This systematic review of epidemiological studies examined the association between maternal exposure to EDCs during pregnancy and the risk of autism spectrum disorder (ASD) in the offspring.MethodsWe searched PubMed, Web of Science, Scopus, and Google Scholar from inception to November 17, 2022, for studies investigating the association between prenatal exposure to EDCs and outcomes related to ASD. Two independent reviewers screened studies for eligibility, extracted data, and assessed the risk of bias. The review was registered in PROSPERO (CRD42023389386).ResultsWe included 27 observational studies assessing prenatal exposure to phthalates (8 studies), polychlorinated biphenyls (8 studies), organophosphate pesticides (8 studies), phenols (7 studies), perfluoroalkyl substances (6 studies), organochlorine pesticides (5 studies), brominated flame retardants (3 studies), dioxins (1 study), and parabens (1 study). The number of examined children ranged from 77 to 1,556, the age at the assessment of autistic traits ranged from 3 to 14 years, and most studies assessed autistic traits using the Social Responsiveness Scale. All but one study was considered to have a low risk of bias. Overall, there was no association between maternal exposure to specific ECDs during pregnancy and the occurrence of autistic traits in offspring.ConclusionsFindings from the epidemiological studies evaluated here do not support an association between prenatal exposure to ECDs and the likelihood of autistic traits in later in life. These findings should not be interpreted as definitive evidence of the absence of neurodevelopment effects of EDCs affecting ASD risk, given the limitations of current studies such as representative exposure assessment, small sample sizes, inadequacy to assess sexually dimorphic effects, or the effects of EDC mixtures. Future studies should carefully address these ...
وصف الملف: application/pdf
العلاقة: qt9p46k3kt; https://escholarship.org/uc/item/9p46k3ktTest
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8دورية أكاديمية
المؤلفون: Iwobi, Nneamaka, Sparks, Nicole R
المصدر: International journal of molecular sciences, vol 24, iss 9
مصطلحات موضوعية: Endocrine System, Hormones, Endocrinology, Signal Transduction, Endocrine Disruptors, bone defects, endocrine toxicity, endocrine-disrupting chemicals, osteoblasts, osteogenesis, Estrogen, Genetics, 2.1 Biological and endogenous factors, Aetiology, Other Chemical Sciences, Other Biological Sciences, Chemical Physics
الوقت: 8263
الوصف: Hormones are indispensable for bone development, growth, and maintenance. While many of the genes associated with osteogenesis are well established, it is the recent findings in endocrinology that are advancing the fields of bone biology and toxicology. Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. Here, we report recent discoveries describing key hormone pathways involved in osteogenesis and the EDCs that alter these pathways. EDCs can lead to bone morphological changes via altering hormone receptors, signaling pathways, and gene expression. The objective of this review is to highlight the recent discoveries of the harmful effects of environmental toxicants on bone formation and the pathways impacted. Understanding the mechanisms of how EDCs interfere with bone formation contributes to providing a comprehensive toxicological profile of a chemical.
وصف الملف: application/pdf
العلاقة: qt9584n12n; https://escholarship.org/uc/item/9584n12nTest; https://escholarship.org/content/qt9584n12n/qt9584n12n.pdfTest
الإتاحة: https://doi.org/10.3390/ijms24098263Test
https://escholarship.org/uc/item/9584n12nTest
https://escholarship.org/content/qt9584n12n/qt9584n12n.pdfTest -
9دورية أكاديمية
المؤلفون: Major, Lauren
المصدر: Capstone Showcase
مصطلحات موضوعية: Plastic, children, health, bpa, phthalates, pediatrics, infertility, Endocrine disrupting chemicals, placental barrier, in utero toxins, EDC impacts, Environmental Public Health, Hormones, Hormone Substitutes, and Hormone Antagonists, Maternal and Child Health
الوصف: Phthalates and Bisphenol A are known Endocrine-Disrupting Chemicals and have demonstrated significant impacts on fertility and the reproductive system. Recent studies suggest exposure to these chemicals to pregnant mothers may adversely impact the health of their children. Exposure to children during significant stages of development may also be associated with increased susceptibility to illnesses such as obesity, diabetes, attention deficit hyperactivity disorder, and others. It is important to encourage public awareness so further studies concerning these possible associations can be conducted. The consequences of these chemicals should be taken seriously by medical professionals and governments to help protect our current and future generations.
وصف الملف: video/mp4
العلاقة: https://scholarworks.arcadia.edu/showcase/2023/pa/85Test; https://scholarworks.arcadia.edu/context/showcase/article/1663/type/native/viewcontent/GMT20230429_010722_Recording_1920x1080.mp4Test; https://scholarworks.arcadia.edu/context/showcase/article/1663/filename/0/type/additional/viewcontent/Poster_Presentation_Template__CME_specific___1_.pptxTest
الإتاحة: https://scholarworks.arcadia.edu/showcase/2023/pa/85Test
https://scholarworks.arcadia.edu/context/showcase/article/1663/type/native/viewcontent/GMT20230429_010722_Recording_1920x1080.mp4Test
https://scholarworks.arcadia.edu/context/showcase/article/1663/filename/0/type/additional/viewcontent/Poster_Presentation_Template__CME_specific___1_.pptxTest -
10تقرير
المؤلفون: Nalandhiran, Pugazhenthiran
المساهمون: Universidad Catolica De La Stma. Concepcion
مصطلحات موضوعية: Reduced graphene oxide {001} facets exposed Black TiO2 nanostructures Solar Photocatalysis, Endocrine Disrupting Chemicals, Ingenieria De Procesos Quimicos
جغرافية الموضوع: Región de Tarapacá, Región de Antofagasta, Región de Atacama, Región de Coquimbo, Región de Valparaíso, Región del Maule, Región del Bío-Bío, Región de La Araucanía, Región de Los Lagos
الوقت: Región de Antofagasta, Región del Libertador General Bernardo O'Higgins
الوصف: RESULTS OBTAINED: For each specific goal, describe or summarize the results obtained. Relate each one to work already published and/or manuscripts submitted. In the Annex section include additional information deemed pertinent and relevant to the evaluation process. The maximum length for this section is 5 pages. (Arial or Verdana, font size 10). Endocrine disrupting chemicals (EDCs) in particular medicines, pesticides, detergents and industrial chemicals at very small (ng/L) concentration cause serious health and environmental effects. Further, millions of people including children lose their life annually due to water-borne diseases caused by the consumption of contaminated fresh water. Fresh-water resources are predominantly polluted by effluents discharged from various industries that are toxic to aquatic environment and human beings. In addition, the accumulation of various synthetic organic compounds such as dyes, phenols, organochlorides, antibiotics and etc., are known to cause great harm to human health (carcinogenic, teratogenic and mutagenic) even when their concentration in water is less than nano-micro molar magnitude. Hence, problems related to water are expected to grow worse in the coming decades with freshwater scarcity occurring globally even in the regions currently endowed with freshwater rich. Addressing these serious problems requires robust advanced technologies for purifying water polluted with synthetic organic compounds wastes in an economical way and with less energy consumption. Unfortunately, conventional wastewater treatment systems are limited to complete removal of EDCs. In view of the above facts, the current research work was focused the state-of-the-art research activities and latest advancements in the design of different nano-structured materials via various strategies, including hydrothermal/solvothermal, solid phase methods and etc. To overcome the large band gap of nano-structured semiconductor materials and rapid recombination of photo generated charge carriers, ...
وصف الملف: application/pdf
العلاقة: Masculino; https://hdl.handle.net/10533/48593Test
