دورية أكاديمية
Computational codes for identification of master regulators of high-risk nasopharyngeal carcinoma
| العنوان: | Computational codes for identification of master regulators of high-risk nasopharyngeal carcinoma |
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| المؤلفون: | Ya-Qin Wang, Dong-Hong Wu, Denghui Wei, Jia-Yi Shen, Zi-Wei Huang, Xiao-Yu Liang, William C.S. Cho, Jun Ma, Jiawei Lv, Yu-Pei Chen |
| سنة النشر: | 2022 |
| المجموعة: | Zenodo |
| الوصف: | The Algorithm for the Reconstruction of Accurate Cellular Networks through Adaptive Partitioning (ARACNe-AP) was applied to construct transcriptional interactomes in gene expression profiles from cohorts of patients with nasopharyngeal carcinoma. Then the Virtual Inference of Protein Activity by Enriched Regulon (VIPER) algorithm was applied to prioritize master regulator proteins based on the inferred transcriptional activity. Scripts: · 1-ARACNe-AP.ps1: PowerShell script for the construct of transcriptional interactomes. · 2-VIPER.R: R script for the identification of master regulator proteins based on the inferred transcriptional activity. Data: · Expression matrix (GSE12452 and GSE102349): Public nasopharyngeal carcinoma datasets, which can be obtained from GEO database (https://www.ncbi.nlm.nih.gov/geoTest/). · Transcription Factors (TFs) list: List of Human transcription factors, which can be obtained from http://humantfs.ccbr.utoronto.ca/download/v_1.01/TF_names_v_1.01.txtTest Please refer to the following paper for more details: Ya-Qin Wang#, Dong-Hong Wu#, Denghui Wei#, Jia-Yi Shen#, Zi-Wei Huang#, et al., Jiawei Lv*, Yu-Pei Chen*. TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/record/7194412Test; https://doi.org/10.5281/zenodo.7194412Test; oai:zenodo.org:7194412 |
| DOI: | 10.5281/zenodo.7194412 |
| الإتاحة: | https://doi.org/10.5281/zenodo.7194412Test https://doi.org/10.5281/zenodo.7194411Test https://zenodo.org/record/7194412Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcodeTest |
| رقم الانضمام: | edsbas.C21E0A9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.7194412 |
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