التفاصيل البيبلوغرافية
| العنوان: |
DataSheet_1_Genomic and Molecular Signatures of Successful Patient-Derived Xenografts for Oral Cavity Squamous Cell Carcinoma.pdf |
| المؤلفون: |
Wei-Chen Yen, Ian Yi-Feng Chang, Kai‐Ping Chang, Chun‐Nan Ouyang, Chiao-Rou Liu, Ting-Lin Tsai, Yi-Cheng Zhang, Chun-I Wang, Ya-Hui Wang, Alice L. Yu, Hsuan Liu, Chih-Ching Wu, Yu-Sun Chang, Jau-Song Yu, Chia-Yu Yang |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, patient-derived xenografts, oral cavity squamous cell carcinoma, whole-exome sequencing, transcriptome sequencing, engraftment ability |
| الوصف: |
Background Oral cavity squamous cell carcinoma (OSCC) is an aggressive malignant tumor with high recurrence and poor prognosis in the advanced stage. Patient-derived xenografts (PDXs) serve as powerful preclinical platforms for drug testing and precision medicine for cancer therapy. We assess which molecular signatures affect tumor engraftment ability and tumor growth rate in OSCC PDXs. Methods Treatment-naïve OSCC primary tumors were collected for PDX models establishment. Comprehensive genomic analysis, including whole-exome sequencing and RNA-seq, was performed on case-matched tumors and PDXs. Regulatory genes/pathways were analyzed to clarify which molecular signatures affect tumor engraftment ability and the tumor growth rate in OSCC PDXs. Results Perineural invasion was found as an important pathological feature related to engraftment ability. Tumor microenvironment with enriched hypoxia, PI3K-Akt, and epithelial–mesenchymal transition pathways and decreased inflammatory responses had high engraftment ability and tumor growth rates in OSCC PDXs. High matrix metalloproteinase-1 (MMP1) expression was found that have a great graft advantage in xenografts and is associated with pooled disease-free survival in cancer patients. Conclusion This study provides a panel with detailed genomic characteristics of OSCC PDXs, enabling preclinical studies on personalized therapy options for oral cancer. MMP1 could serve as a biomarker for predicting successful xenografts in OSCC patients. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/DataSheet_1_Genomic_and_Molecular_Signatures_of_Successful_Patient-Derived_Xenografts_for_Oral_Cavity_Squamous_Cell_Carcinoma_pdf/19502734Test |
| DOI: |
10.3389/fonc.2022.792297.s001 |
| الإتاحة: |
https://doi.org/10.3389/fonc.2022.792297.s001Test
https://figshare.com/articles/dataset/DataSheet_1_Genomic_and_Molecular_Signatures_of_Successful_Patient-Derived_Xenografts_for_Oral_Cavity_Squamous_Cell_Carcinoma_pdf/19502734Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.B0E98020 |
| قاعدة البيانات: |
BASE |
