التفاصيل البيبلوغرافية
| العنوان: |
Exploiting the therapeutic potential of the PI3K-AKT-mTOR pathway in enriched populations of gynecologic malignancies |
| المؤلفون: |
Eskander, Ramez N, Tewari, Krishnansu S |
| المصدر: |
Expert Review of Clinical Pharmacology, vol 7, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2014 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cervical Cancer, Uterine Cancer, Clinical Trials and Supportive Activities, Clinical Research, Cancer, Biotechnology, Rare Diseases, Animals, Antineoplastic Agents, Clinical Trials, Phase II as Topic, Drug Design, Female, Genital Neoplasms, Humans, Neoplasm Recurrence, Local, Phosphoinositide-3 Kinase Inhibitors, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, clear cell ovarian cancer, endometrial cancer, mTOR inhibitors, PI3K/AKT/mTOR pathway, PTEN, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy |
| جغرافية الموضوع: |
847 - 858 |
| الوصف: |
Given the prevalence of phosphatase & tensin homolog mutations in histologic specimens harvested from patients with endometrial cancer, significant interest in systemic treatment with PI3K/Akt/mTOR inhibitors has emerged. Several Phase II trials have been completed studying mTOR inhibitors in advanced/recurrent endometrial cancer. The mTOR pathway also appears to be important in some cervical cancers. Finally, because clear cell carcinoma of the ovary and renal cell carcinoma have a shared histology, the potential for activity of mTOR inhibitors in clear cell cancer of the ovary is implicit. This article reviews the results of Phase II clinical trials of PI3K/Akt/mTOR pathway inhibitors in patients with endometrial cancer, and discusses the potential therapeutic landscape of mTOR inhibition in enriched populations in gynecologic cancers. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt01p8v6nv; https://escholarship.org/uc/item/01p8v6nvTest |
| الإتاحة: |
https://escholarship.org/uc/item/01p8v6nvTest |
| حقوق: |
CC-BY |
| رقم الانضمام: |
edsbas.1FF691BC |
| قاعدة البيانات: |
BASE |
