التفاصيل البيبلوغرافية
| العنوان: |
Toxicoanthropology: Phthalate exposure in relation to market access in a remote forager-horticulturalist population |
| المؤلفون: |
Sobolewski, Marissa, Weiss, Bernard, Martin, Melanie, Gurven, Michael, Barrett, Emily |
| المصدر: |
International Journal of Hygiene and Environmental Health, vol 220, iss 5 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2017 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Contraception/Reproduction, Clinical Research, Estrogen, Reproductive health and childbirth, Good Health and Well Being, Adolescent, Adult, Agriculture, Bolivia, Chorionic Gonadotropin, Environmental Monitoring, Environmental Pollutants, Estrone, Female, Follicle Stimulating Hormone, Humans, Phthalic Acids, Plasticizers, Pregnanediol, Young Adult, Phthalates, Global marketplace, Toxicoanthropology, Endocrine disrupting chemicals, Low concentration exposure, Public Health and Health Services, Epidemiology, Toxicology |
| جغرافية الموضوع: |
799 - 809 |
| الوصف: |
Phthalates are a class of plasticizing chemicals produced in high volume and widely found in consumer products. Evidence suggests that phthalates may have non-monotonic effects on reproductive hormone activity. With exposure to phthalates virtually ubiquitous among industrialized populations, identifying unexposed and/or minimally exposed human populations is essential for understanding the effects of low level exposures. Our primary objective was to quantify urinary phthalate metabolite concentrations in the Tsimane', a remote population of Bolivian forager-horticulturalists. Our secondary objectives were to determine if phthalate metabolite concentrations vary in relation to access to market goods; and to explore relationships between phthalate and reproductive hormone metabolite concentrations. Given that phthalate exposure is of particular concern during fetal development, we focused on reproductive age women in the current analyses. Phthalate metabolites were assayed in urine samples from 59 naturally cycling, reproductive age Tsimane' women. Market access was assessed as: (1) distance from residence to the largest nearby town (San Borja, Bolivia) and (2) Spanish fluency. Urinary reproductive hormone metabolite concentrations were quantified using enzyme immunoassays. We fit linear models to examine: (1) predictors of phthalate exposure; and (2) relationships between urinary phthalate and reproductive hormone metabolite concentrations. Eight phthalate metabolites were detectable in at least 75% of samples. Median concentrations were up to an order of magnitude lower than industrialized populations. Proximity to San Borja and Spanish fluency were strong predictors of exposure. In exploratory analyses, the sum of the di-2-ethylhexyl phthalate metabolites (∑DEHP) and Mono-isobutyl phthalate (MiBP) were significantly associated with altered concentrations of urinary reproductive hormone metabolites. Remote, subsistence populations, like the Tsimane', offer a unique window into the health effects of endocrine ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt8c61v3bd; https://escholarship.org/uc/item/8c61v3bdTest |
| الإتاحة: |
https://escholarship.org/uc/item/8c61v3bdTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.F58F0538 |
| قاعدة البيانات: |
BASE |
