التفاصيل البيبلوغرافية
| العنوان: |
Differences in nicotine intake and effects from electronic and combustible cigarettes among dual users |
| المؤلفون: |
St.Helen, Gideon, Nardone, Natalie, Addo, Newton, Dempsey, Delia, Havel, Christopher, Jacob, Peyton, Benowitz, Neal L |
| المصدر: |
Addiction, vol 115, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biological Psychology, Psychology, Tobacco, Tobacco Smoke and Health, Substance Misuse, Clinical Research, Drug Abuse (NIDA only), Good Health and Well Being, Adult, Affect, Craving, Cross-Over Studies, Electronic Nicotine Delivery Systems, Female, Humans, Male, Nicotine, San Francisco, Smoking, Substance Withdrawal Syndrome, Tobacco Products, Dual users, e-cigarettes, e-cigarette dependence, JUUL PK profile, subjective effects, nicotine pharmacokinetics, Medical and Health Sciences, Psychology and Cognitive Sciences, Substance Abuse |
| جغرافية الموضوع: |
757 - 767 |
| الوصف: |
AimTo describe systemic nicotine exposure and subjective effects of electronic cigarettes (e-cigarettes) in people who use both e-cigarettes and cigarettes (dual users), including within-subject comparisons of e-cigarette and cigarette use.DesignTwo-arm, counterbalanced cross-over study. Participants used their usual brand of e-cigarette or cigarette during a standardized session in a 2-week study.SettingHospital research ward, San Francisco, CA, USA.ParticipantsThirty-six healthy (eight women, 28 men) participants.MeasurementsPlasma nicotine was analyzed by gas chromatography-tandem mass spectrometry; nicotine withdrawal, urge to smoke and vape, affective states, craving, satisfaction and psychological reward were measured by standardized questionnaires.FindingsCompared with cigarettes, average maximum plasma nicotine concentration (Cmax ) was lower with e-cigarettes [6.1±5.5ng/ml, mean ±standard deviation (SD) versus 20.2±11.1ng/ml, P<0.001] and time of maximal concentration (Tmax ) was longer (6.5±5.4versus 2.7±2.4minutes, P<0.001). Use of both products resulted in a reduction in the severity of withdrawal symptoms, negative affect and urge to use either product. E-cigarettes were less rewarding and satisfying and reduced craving to a lesser degree than cigarettes. We were not able to detect any differences in withdrawal symptoms, affective states and urge to smoke cigarettes between e-cigarette and cigarette use.ConclusionSystemic nicotine exposure was, on average, lower with single use of e-cigarettes compared with cigarettes, and e-cigarettes were judged to be less satisfying and rewarding and reduced craving less than cigarettes. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3f2870qq; https://escholarship.org/uc/item/3f2870qqTest |
| الإتاحة: |
https://escholarship.org/uc/item/3f2870qqTest |
| حقوق: |
CC-BY-NC-SA |
| رقم الانضمام: |
edsbas.418032D6 |
| قاعدة البيانات: |
BASE |
