دورية أكاديمية
Modeling human T1D-associated autoimmune processes.
| العنوان: | Modeling human T1D-associated autoimmune processes. |
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| المؤلفون: | Khosravi-Maharlooei, Mohsen, Madley, Rachel, Borsotti, Chiara, Ferreira, Leonardo MR, Sharp, Robert C, Brehm, Michael A, Greiner, Dale L, Parent, Audrey V, Anderson, Mark S, Sykes, Megan, Creusot, Remi J |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2022 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Immune System, Animals, Humans, Mice, Diabetes Mellitus, Type 1, Insulin-Secreting Cells, Autoimmunity, Beta cell destruction, Disease modeling, Humanized mice, In vitro models, Type 1 diabetes, Clinical Research, Autoimmune Disease, Pediatric, Prevention, Diabetes, Genetics, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Metabolic and endocrine, Biochemistry and Cell Biology, Physiology |
| الوصف: | BackgroundType 1 diabetes (T1D) is an autoimmune disease characterized by impaired immune tolerance to β-cell antigens and progressive destruction of insulin-producing β-cells. Animal models have provided valuable insights for understanding the etiology and pathogenesis of this disease, but they fall short of reflecting the extensive heterogeneity of the disease in humans, which is contributed by various combinations of risk gene alleles and unique environmental factors. Collectively, these factors have been used to define subgroups of patients, termed endotypes, with distinct predominating disease characteristics.Scope of reviewHere, we review the gaps filled by these models in understanding the intricate involvement and regulation of the immune system in human T1D pathogenesis. We describe the various models developed so far and the scientific questions that have been addressed using them. Finally, we discuss the limitations of these models, primarily ascribed to hosting a human immune system (HIS) in a xenogeneic recipient, and what remains to be done to improve their physiological relevance.Major conclusionsTo understand the role of genetic and environmental factors or evaluate immune-modifying therapies in humans, it is critical to develop and apply models in which human cells can be manipulated and their functions studied under conditions that recapitulate as closely as possible the physiological conditions of the human body. While microphysiological systems and living tissue slices provide some of these conditions, HIS mice enable more extensive analyses using invivo systems. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt602477rk; https://escholarship.org/uc/item/602477rkTest; https://escholarship.org/content/qt602477rk/qt602477rk.pdfTest |
| DOI: | 10.1016/j.molmet.2021.101417 |
| الإتاحة: | https://doi.org/10.1016/j.molmet.2021.101417Test https://escholarship.org/uc/item/602477rkTest https://escholarship.org/content/qt602477rk/qt602477rk.pdfTest |
| حقوق: | public |
| رقم الانضمام: | edsbas.5F95B102 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.molmet.2021.101417 |
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