التفاصيل البيبلوغرافية
| العنوان: |
Respiratory exacerbations are associated with muscle loss in current and former smokers |
| المؤلفون: |
Mason, Stefanie Elizabeth, Moreta-Martinez, Rafael, Labaki, Wassim W, Strand, Matthew, Baraghoshi, David, Regan, Elizabeth A, Bon, Jessica, San Jose Estepar, Ruben, Casaburi, Richard, McDonald, Merry-Lynn N, Rossiter, Harry, Make, Barry J, Dransfield, Mark T, Han, MeiLan K, Young, Kendra A, Kinney, Greg, Hokanson, John E, San Jose Estepar, Raul, Washko, George R |
| المصدر: |
Thorax, vol 76, iss 6 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2021 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Lung, Clinical Research, Chronic Obstructive Pulmonary Disease, Respiratory, Aged, Disease Progression, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Muscular Atrophy, Population Surveillance, Prognosis, Prospective Studies, Pulmonary Disease, Chronic Obstructive, Quality of Life, Severity of Illness Index, Smoking, Tomography, X-Ray Computed, COPD exacerbations, imaging, CT MRI etc, pulmonary rehabilitation, COPDGene Investigators |
| جغرافية الموضوع: |
554 - 560 |
| الوصف: |
ObjectivesMuscle wasting is a recognised extra-pulmonary complication in chronic obstructive pulmonary disease and has been associated with increased risk of death. Acute respiratory exacerbations are associated with reduction of muscle function, but there is a paucity of data on their long-term effect. This study explores the relationship between acute respiratory exacerbations and long-term muscle loss using serial measurements of CT derived pectoralis muscle area (PMA).Design and settingParticipants were included from two prospective, longitudinal, observational, multicentre cohorts of ever-smokers with at least 10 pack-year history.ParticipantsThe primary analysis included 1332 (of 2501) participants from Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) and 4384 (of 10 198) participants from Genetic Epidemiology of COPD (COPDGene) who had complete data from their baseline and follow-up visits.InterventionsPMA was measured on chest CT scans at two timepoints. Self-reported exacerbation data were collected from participants in both studies through the use of periodic longitudinal surveys.Main outcome measuresAge-related and excess muscle loss over time.ResultsAge, sex, race and body mass index were associated with baseline PMA. Participants experienced age-related decline at the upper end of reported normal ranges. In ECLIPSE, the exacerbation rate over time was associated with an excess muscle area loss of 1.3% (95% CI 0.6 to 1.9, p<0.001) over 3 years and in COPDGene with an excess muscle area loss of 2.1% (95% CI 1.2 to 2.8, p<0.001) over 5 years. Excess muscle area decline was absent in 273 individuals who participated in pulmonary rehabilitation.ConclusionsExacerbations are associated with accelerated skeletal muscle loss. Each annual exacerbation was associated with the equivalent of 6 months of age-expected decline in muscle mass. Ameliorating exacerbation-associated muscle loss represents an important therapeutic target. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt4rd4t85x; https://escholarship.org/uc/item/4rd4t85xTest |
| الإتاحة: |
https://escholarship.org/uc/item/4rd4t85xTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.AD881137 |
| قاعدة البيانات: |
BASE |
