التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_Longitudinal Alterations in Gait Features in Growing Children With Duchenne Muscular Dystrophy.docx |
| المؤلفون: |
Ines Vandekerckhove, Marleen Van den Hauwe, Nathalie De Beukelaer, Elze Stoop, Marije Goudriaan, Margaux Delporte, Geert Molenberghs, Anja Van Campenhout, Liesbeth De Waele, Nathalie Goemans, Friedl De Groote, Kaat Desloovere |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Neuroscience, Exercise Physiology, Central Nervous System, Computer Perception, Memory and Attention, Decision Making, Neurocognitive Patterns and Neural Networks, Music Therapy, Duchenne muscular dystrophy, typically developing children, three-dimensional gait analysis, gait pattern, longitudinal study, mixed models for repeated measures |
| الوصف: |
Prolonging ambulation is an important treatment goal in children with Duchenne muscular dystrophy (DMD). Three-dimensional gait analysis (3DGA) could provide sensitive parameters to study the efficacy of clinical trials aiming to preserve ambulation. However, quantitative descriptions of the natural history of gait features in DMD are first required. The overall goal was to provide a full delineation of the progressive gait pathology in children with DMD, covering the entire period of ambulation, by performing a so-called mixed cross-sectional longitudinal study. Firstly, to make our results comparable with previous literature, we aimed to cross-sectionally compare 31 predefined gait features between children with DMD and a typically developing (TD) database (1). Secondly, we aimed to explore the longitudinal changes in the 31 predefined gait features in growing boys with DMD using follow-up 3DGA sessions (2). 3DGA-sessions (n = 124) at self-selected speed were collected in 27 boys with DMD (baseline age: 4.6–15 years). They were repeatedly measured over a varying follow-up period (range: 6 months–5 years). The TD group consisted of 27 children (age: 5.4–15.6 years). Per measurement session, the spatiotemporal parameters, and the kinematic and kinetic waveforms were averaged over the selected gait cycles. From the averaged waveforms, discrete gait features (e.g., maxima and minima) were extracted. Mann-Whitney U tests were performed to cross-sectionally analyze the differences between DMD at baseline and TD (1). Linear mixed effect models were performed to assess the changes in gait features in the same group of children with DMD from both a longitudinal (i.e., increasing time) as well as a cross-sectional perspective (i.e., increasing baseline age) (2). At baseline, the boys with DMD differed from the TD children in 17 gait features. Additionally, 21 gait features evolved longitudinally when following-up the same boys with DMD and 25 gait features presented a significant cross-sectional baseline age-effect. The ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Data_Sheet_1_Longitudinal_Alterations_in_Gait_Features_in_Growing_Children_With_Duchenne_Muscular_Dystrophy_docx/19956158Test |
| DOI: |
10.3389/fnhum.2022.861136.s001 |
| الإتاحة: |
https://doi.org/10.3389/fnhum.2022.861136.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Longitudinal_Alterations_in_Gait_Features_in_Growing_Children_With_Duchenne_Muscular_Dystrophy_docx/19956158Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.DBC8CF63 |
| قاعدة البيانات: |
BASE |
