دورية أكاديمية
Plasma microRNA profiling reveals novel biomarkers of epicardial adipose tissue: A multidetector computed tomography study
| العنوان: | Plasma microRNA profiling reveals novel biomarkers of epicardial adipose tissue: A multidetector computed tomography study |
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| المؤلفون: | Gonzalo-Calvo, David de, Vilades, David, Martínez-Camblor, Pablo, Vea, Ángela, Ferrero-Gregori, Andreu, Nasarre, Laura, Bornachea, Olga, Sanchez Vega, J., Leta, Rubén, Puig, Núria, Benítez, Sonia, Sánchez-Quesada, José Luís, Carreras, Francesc, Llorente-Cortés, Vicenta |
| المساهمون: | Ministerio de Economía y Competitividad (España), Fundació La Marató de TV3, Instituto de Salud Carlos III, European Commission, Gonzalo-Calvo, David de, Martínez-Camblor, Pablo |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2019 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Biomarkers, Cardiometabolic diseases, Epicardial adipose tissue, Epicardial fat, Epicardial fat volume, MicroRNA |
| الوصف: | Epicardial adipose tissue (EAT) constitutes a novel parameter for cardiometabolic risk assessment and a target for therapy. Here, we evaluated for the first time the plasma microRNA (miRNA) profile as a source of biomarkers for epicardial fat volume (EFV). miRNAs were profiled in plasma samples from 180 patients whose EFV was quantified using multidetector computed tomography. In the screening study, 54 deregulated miRNAs were identified in patients with high EFV levels (highest tertile) compared with matched patients with low EFV levels (lowest tertile). After filtering, 12 miRNAs were selected for subsequent validation. In the validation study, miR-15b-3p, miR-22-3p, miR-148a-3p miR-148b-3p and miR-590-5p were directly associated with EFV, even after adjustment for confounding factors (p value < 0.05 for all models). The addition of miRNA combinations to a model based on clinical variables improved the discrimination (area under the receiver-operating-characteristic curve (AUC) from 0.721 to 0.787). miRNAs correctly reclassified a significant proportion of patients with an integrated discrimination improvement (IDI) index of 0.101 and a net reclassification improvement (NRI) index of 0.650. Decision tree models used miRNA combinations to improve their classification accuracy. These results were reproduced using two proposed clinical cutoffs for epicardial fat burden. Internal validation corroborated the robustness of the models. In conclusion, plasma miRNAs constitute novel biomarkers of epicardial fat burden. ; D.d.G.-C. was a recipient of a Juan de la Cierva-Incorporación grant from the Ministerio de Economía y Competitividad (IJCI-2016-29393). O.B. (Project 201521-10) and N.P. (Project 201716) were recipients of Fundació Marató TV3. S.B. and J.L.S.-Q. (2017-SGR-1149) and D.d.G.-C., L.N., À.V., D.V., R.L. and V.L.-C. (2017-SGR-946) are members of Quality Research Groups from Generalitat de Catalunya. S.B., J.L.S.-Q., N.P., V.L.-C. and D.d.G.-C. are members of the Group of Vascular Biology of the Spanish ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 2077-0383 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2016-29393; Publisher’s version; https://doi.org/10.3390/jcm8060780Test; Sí; Journal of Clinical Medicine 8(6): 780 (2019); http://hdl.handle.net/10261/185043Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100004587Test; http://dx.doi.org/10.13039/501100003329Test; http://dx.doi.org/10.13039/100008666Test |
| DOI: | 10.3390/jcm8060780 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100003329 |
| DOI: | 10.13039/100008666 |
| الإتاحة: | https://doi.org/10.3390/jcm8060780Test https://doi.org/10.13039/501100000780Test https://doi.org/10.13039/501100004587Test https://doi.org/10.13039/501100003329Test https://doi.org/10.13039/100008666Test http://hdl.handle.net/10261/185043Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.E2EF4036 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20770383 |
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| DOI: | 10.3390/jcm8060780 |