التفاصيل البيبلوغرافية
| العنوان: |
NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8 |
| المؤلفون: |
Rauch, Isabella, Deets, Katherine A, Ji, Daisy X, von Moltke, Jakob, Tenthorey, Jeannette L, Lee, Angus Y, Philip, Naomi H, Ayres, Janelle S, Brodsky, Igor E, Gronert, Karsten, Vance, Russell E |
| المصدر: |
Immunity, vol 46, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2017 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Foodborne Illness, Prevention, Vaccine Related, Digestive Diseases, Biodefense, Emerging Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Animals, Apoptosis Regulatory Proteins, Calcium-Binding Proteins, Caspase 1, Caspase 8, Eicosanoids, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Inflammasomes, Interleukin-18, Intestinal Mucosa, Intracellular Signaling Peptides and Proteins, Mice, Inbred C57BL, Knockout, Transgenic, Microscopy, Confocal, Neuronal Apoptosis-Inhibitory Protein, Phosphate-Binding Proteins, Salmonella Infections |
| جغرافية الموضوع: |
649 - 659 |
| الوصف: |
Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By generation of mice inwhich inflammasome expression is restricted to IECs, we describe a coordinated epithelium-intrinsic inflammasome response invivo. This response was sufficient to protect against Salmonella tissue invasion and involved a previously reported IEC expulsion that was coordinated with lipid mediator and cytokine production and lytic IEC death. Excessive inflammasome activation in IECs was sufficient to result in diarrhea and pathology. Experiments with IEC organoids demonstrated that IEC expulsion didnot require other cell types. IEC expulsion was accompanied by a major actin rearrangement in neighboring cells that maintained epithelium integrity but did not absolutely require Caspase-1 or Gasdermin D. Analysis of Casp1-/-Casp8-/- mice revealed a functional Caspase-8 inflammasome invivo. Thus, a coordinated IEC-intrinsic, Caspase-1 and -8 inflammasome response plays a key role in intestinal immune defense and pathology. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3st853r8; https://escholarship.org/uc/item/3st853r8Test |
| الإتاحة: |
https://escholarship.org/uc/item/3st853r8Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.2105B4EB |
| قاعدة البيانات: |
BASE |
