التفاصيل البيبلوغرافية
| العنوان: |
Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis |
| المؤلفون: |
Hawerkamp, Heike C, van Geelen, Lasse, Korte, Jan, Di Domizio, Jeremy, Swidergall, Marc, Momin, Afaque A, Guzmán-Vega, Francisco J, Arold, Stefan T, Ernst, Joachim, Gilliet, Michel, Kalscheuer, Rainer, Homey, Bernhard, Meller, Stephan |
| المصدر: |
Scientific Reports, vol 10, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Infectious Diseases, HIV/AIDS, Tuberculosis, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Inflammatory and immune system, Good Health and Well Being, Adult, Aged, Cell Line, Cytokines, Dendritic Cells, Female, HEK293 Cells, Humans, Interleukins, Leukocytes, Mononuclear, Macrophages, Male, Middle Aged, Mycobacterium tuberculosis, RNA, Messenger |
| الوصف: |
Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (TH1) and TH17 cells are recruited to the site of infection. The TH17 cell-derived interleukin (IL)-17 in turn induces the cathelicidin LL37 which shows direct antimycobacterial effects. Here, we investigated the role of IL-26, a TH1- and TH17-associated cytokine that exhibits antimicrobial activity. We found that both IL-26 mRNA and protein are strongly increased in tuberculous lymph nodes. Furthermore, IL-26 is able to directly kill Mtb and decrease the infection rate in macrophages. Binding of IL-26 to lipoarabinomannan might be one important mechanism in extracellular killing of Mtb. Macrophages and dendritic cells respond to IL-26 with secretion of tumor necrosis factor (TNF)-α and chemokines such as CCL20, CXCL2 and CXCL8. In dendritic cells but not in macrophages cytokine induction by IL-26 is partly mediated via Toll like receptor (TLR) 2. Taken together, IL-26 strengthens the defense against Mtb in two ways: firstly, directly due to its antimycobacterial properties and secondly indirectly by activating innate immune mechanisms. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt7f48p9p3; https://escholarship.org/uc/item/7f48p9p3Test |
| الإتاحة: |
https://escholarship.org/uc/item/7f48p9p3Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.9B4895C7 |
| قاعدة البيانات: |
BASE |
