التفاصيل البيبلوغرافية
| العنوان: |
Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. |
| المؤلفون: |
Jiang, Wei, De Belly, Henry, Wang, Bingying, Wong, Andrew, Kim, Minseo, Oh, Fiona, DeGeorge, Jason, Huang, Xinya, Guang, Shouhong, Weiner, Orion, Ma, Dengke |
| المصدر: |
Science Advances, vol 10, iss 4 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2024 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Adult, Humans, Animals, Longevity, Thrombospondin 1, Adverse Childhood Experiences, Caenorhabditis elegans, Resilience, Psychological, Tetraspanins, Transcription Factors, Caenorhabditis elegans Proteins, Histone Acetyltransferases |
| الوصف: |
Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates tsp-1, a gene encoding the conserved transmembrane tetraspanin in C. elegans. TSP-1 forms prominent multimers and stable web-like structures critical for membrane barrier functions in adults and during aging. Increased TSP-1 abundance persists even after transient early-life heat stress. Such regulation requires CBP-1, a histone acetyltransferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt5fw4s85p; https://escholarship.org/uc/item/5fw4s85pTest |
| الإتاحة: |
https://escholarship.org/uc/item/5fw4s85pTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.E4FD69CA |
| قاعدة البيانات: |
BASE |
