التفاصيل البيبلوغرافية
| العنوان: |
The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation |
| المؤلفون: |
Volmering, Stephanie, Block, Helena, Boras, Mark, Lowell, Clifford A, Zarbock, Alexander |
| المصدر: |
Immunity, vol 44, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2016 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Immunology, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Agammaglobulinaemia Tyrosine Kinase, Animals, Flow Cytometry, Inflammation, Integrins, Liver Diseases, Mice, Microscopy, Confocal, N-Formylmethionine Leucyl-Phenylalanine, Necrosis, Neutrophil Infiltration, Protein-Tyrosine Kinases, Signal Transduction, Btk, Src family kinases, WASp, fMLF, integrin, phospholipase C, signaling |
| جغرافية الموضوع: |
73 - 87 |
| الوصف: |
Neutrophils are recruited from the blood to sites of sterile inflammation, where they are involved in wound healing but can also cause tissue damage. During sterile inflammation, necrotic cells release pro-inflammatory molecules including formylated peptides. However, the signaling pathway triggered by formylated peptides to integrin activation and leukocyte recruitment is unknown. By using spinning-disk confocal intravital microscopy, we examined the molecular mechanisms of leukocyte recruitment to sites of focal hepatic necrosis invivo. Wedemonstrated that the Bruton's tyrosine kinase (Btk) was required for multiple Mac-1 activation events involved in neutrophil recruitment and functions during sterile inflammation triggered by fMLF. The Src family kinase Hck, Wiskott-Aldrich-syndrome protein, and phospholipase Cγ2 were also involved in this pathway required for fMLF-triggered Mac-1 activation and neutrophil recruitment. Thus, we have identified a neutrophil Btk signalosome that is involved in a signaling pathway triggered by formylated peptides leading to the selective activation of Mac-1 and neutrophil recruitment during sterile inflammation. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt4c56h6d5; https://escholarship.org/uc/item/4c56h6d5Test |
| الإتاحة: |
https://escholarship.org/uc/item/4c56h6d5Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.6AAF9A6A |
| قاعدة البيانات: |
BASE |
