دورية أكاديمية
Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing
| العنوان: | Longitudinal myocardial dysfunction in healthy older subjects as a manifestation of cardiac ageing |
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| المؤلفون: | Nikitin, Nikolay P., Witte, Klaus K.A., Ingle, Lee, Clark, Andrew L., Farnsworth, T. Alan, Cleland, John G.F. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2005 |
| المجموعة: | University of Hull: Repository@Hull |
| مصطلحات موضوعية: | Ageing, Ventricular function, Left, systole, Diastole, Echocardiography, Doppler, Elderly, Longitudinal myocardial dysfunction, Cardiac ageing, Health and Health Inequalities |
| الوصف: | Background: Abnormalities of longitudinal left ventricular (LV) contraction and relaxation may be early markers of cardiac disease. This study was designed to assess the relationship between long-axis LV function and age in healthy subjects. Methods: 118 healthy individuals aged 57 ±19 years (range 20-90 years) with no evidence of cardiovascular disease under-went echocardiography with Doppler examination of transmitral flow. To assess longitudinal LV function, systolic (S m ), early diastolic (E m ) and late diastolic (A m ) mitral annular velocities were measured using colour-coded tissue Doppler imaging. Results: The left atrium was enlarged (P < 0.001) in subjects ≥60 years of age compared to those < 60 years, but there were no differences in LV volumetric indices and ejection fraction. Peak E velocity was lower (P < 0.001) and peak A velocity of transmitral flow was higher in older subjects (P < 0.001) with a higher E/A ratio (P < 0.001) and longer isovolumic relaxation time (P = 0.001) indicative of impaired ventricular relaxation. S m and E m mitral annular velocities decreased (P < 0.001) and A m velocity increased (P = 0.002) in the older group. E m velocity and E m /A m ratio showed a strong negative correlation with age (r = -0.80, P < 0.001 and r = -0.78, P < 0.001, respectively). Conclusions: Global LV systolic function is preserved but the velocity of long-axis systolic shortening is depressed in older individuals, indicating selective impairment of the longitudinal component of systolic contraction. The decline in the velocity of early diastolic long-axis LV lengthening and the changes in the pattern of transmitral flow suggest impaired ventricular relaxation. These measures of cardiac function may be a useful index of normal cardiac ageing. © The Author 2005. Published by Oxford University Press. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0002-0729 |
| العلاقة: | https://hull-repository.worktribe.com/output/738447Test; Age and Ageing; Volume 34; Issue 4; Pagination 343-349 |
| DOI: | 10.1093/ageing/afi043 |
| الإتاحة: | https://doi.org/10.1093/ageing/afi043Test https://hull-repository.worktribe.com/output/738447Test |
| رقم الانضمام: | edsbas.2CE21794 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00020729 |
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| DOI: | 10.1093/ageing/afi043 |