دورية أكاديمية
Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress
| العنوان: | Up regulation of IL-6 by ischemic preconditioning in normal and fatty rat livers: Association with reduction of oxidative stress |
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| المؤلفون: | Tacchini, Lorenza, Cairo, Gaetano, De Ponti, Cristina, Massip-Salcedo, Marta, Roselló-Catafau, Joan, Peralta, Carmen |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2006 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Oxidative stress, Redox reactions, Transcription factors, Reperfusion |
| الوصف: | We analyzed the role of IL-6 in the protection that ischemic preconditioning (IP) exerts against hepatic ischemia reperfusion-mediated (I/R) oxidative damage, particularly in fatty livers. IP-related IL-6 up-regulation during reperfusion in steatotic and non-steatotic livers was correlated with reduced indices of liver damage, as also demonstrated by pharmacological modulation of IL-6. IP activated NF-κB and HSF during ischemia (Isc), whereas AP-1 activity was unaffected. IP blunted the activation of STAT3 and stress-responsive genes, such as NF-κB, AP-1 and heme oxygenase (HO-1) during reperfusion. The role of reduced oxidative stress in hepatoprotection of fatty livers was further demonstrated by the fact that: (i) IP prevented the decrease of glutathione levels and the increase of lipid peroxidation; (ii) the anti-oxidant GSH-ester prevented lipid peroxidation and necrosis. In conclusion, IP modulates the activity of transcription factors and triggers IL-6 production; this may prevent hepatic I/R damage in a oxidative stress-dependent way, particularly in fatty livers. ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1071-5762 |
| العلاقة: | http://dx.doi.org/10.1080/10715760600885432Test; Free Radical Research 40(11): 1206-1217 (2006); http://hdl.handle.net/10261/114105Test |
| DOI: | 10.1080/10715760600885432 |
| الإتاحة: | https://doi.org/10.1080/10715760600885432Test http://hdl.handle.net/10261/114105Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.DB8E4F24 |
| قاعدة البيانات: | BASE |
| تدمد: | 10715762 |
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| DOI: | 10.1080/10715760600885432 |