دورية أكاديمية
Histamine: neural circuits and new medications
| العنوان: | Histamine: neural circuits and new medications |
|---|---|
| المؤلفون: | Scammell, TE, Jackson, AC, Franks, NP, Wisden, W, Dauvilliers, Y |
| المساهمون: | Wellcome Trust, UK DRI Ltd |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2018 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, histamine, H1R, H3R, pitolisant, diphenhydramine, narcolepsy, sedative, sleepiness, tuberomammillary nucleus, orexin, CEREBROSPINAL-FLUID HISTAMINE, SLEEP-WAKING DISCHARGE, EYE-MOVEMENT SLEEP, POSTERIOR HYPOTHALAMUS, H-3 RECEPTOR, ELECTROPHYSIOLOGICAL DIVERSITY, GABA(A) RECEPTORS, SYNAPTIC RELEASE, BRAIN HISTAMINE, 06 Biological Sciences, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences, Neurology & Neurosurgery |
| الوصف: | Histamine was first identified in the brain about 50 years ago, but only in the last few years have researchers gained an understanding of how it regulates sleep/wake behavior. We provide a translational overview of the histamine system, from basic research to new clinical trials demonstrating the usefulness of drugs that enhance histamine signaling. The tuberomammillary nucleus is the sole neuronal source of histamine in the brain, and like many of the arousal systems, histamine neurons diffusely innervate the cortex, thalamus, and other wake-promoting brain regions. Histamine has generally excitatory effects on target neurons, but paradoxically, histamine neurons may also release the inhibitory neurotransmitter GABA. New research demonstrates that activity in histamine neurons is essential for normal wakefulness, especially at specific circadian phases, and reducing activity in these neurons can produce sedation. The number of histamine neurons is increased in narcolepsy, but whether this affects brain levels of histamine is controversial. Of clinical importance, new compounds are becoming available that enhance histamine signaling, and clinical trials show that these medications reduce sleepiness and cataplexy in narcolepsy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0161-8105 |
| العلاقة: | Sleep; http://hdl.handle.net/10044/1/63300Test; https://doi.org/10.1093/sleep/zsy183Test; 107841/Z/15/Z; 107839/Z/15/Z |
| DOI: | 10.1093/sleep/zsy183 |
| الإتاحة: | https://doi.org/10.1093/sleep/zsy183Test http://hdl.handle.net/10044/1/63300Test |
| حقوق: | © 2018 Sleep Research Society. Published by Oxford University Press [on behalf of the Sleep Research Society]. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| رقم الانضمام: | edsbas.8623A261 |
| قاعدة البيانات: | BASE |
| تدمد: | 01618105 |
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| DOI: | 10.1093/sleep/zsy183 |