التفاصيل البيبلوغرافية
| العنوان: |
Recent Advances in Induced Pluripotent Stem Cell (iPSC) Based Therapeutics |
| المؤلفون: |
Santosh Gupta, Vineeta Sharma and Rama Shanker Verma* |
| بيانات النشر: |
MedCrave |
| سنة النشر: |
2017 |
| المجموعة: |
MedCrave |
| مصطلحات موضوعية: |
Pluripotent stem cell, Cell therapeutics, Induced Pluripotent Stem Cells, Embryonic Stem Cells, Somatic Cell Nuclear Transfer, Transcription Factors, Sex Determining Region Y-box 2, Krueppel-like factor 4, Undifferentiated Embryonic Cell Transcription factor 1, Sal-like protein 4, Telomerase Reverse Transcriptase, Histone Acetyltransferase, CREB Binding Protein, Mesenchymal Stem Cells, Pancreatic Cancer Cell model, Brain Micro Vascular Endothelial Cells, Huntington Disease |
| الوصف: |
Induced Pluripotent Stem Cells (iPSC) has revolutionized the scientific field in the last decade and our approach related to stem cells based tissue engineering/regenerative medicine for disease treatment. iPSC are cells capable of differentiating into any adult/germ cells under specific condition of growth. This has led to the development of functional parenchymal cells of all the major organs till date. Particularly in the last few years we have seen a surge in development of tissue constructs on the foundation of developmental biology and tissue engineering methodology to move towards a more feasible direction of using iPSC in developing tissues/glands that can be used to replaced eteriorating/dysfunctional part of any vital organs. This review gives a brief introduction about chronological history of what led to the development of iPSCs, the mechanistic insight of pluripotency induction, molecules associated with iPSC derivation. We have also discussed about the recent advancements of use of iPSC in tissue engineering of vital organs and disease modelling, their associated limitations, and finally the advantages and limitations of iPSC technology and its future application. |
| نوع الوثيقة: |
review |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
http://medcraveonline.com/JSRT/JSRT-03-00100.pdfTest |
| الإتاحة: |
http://medcraveonline.com/JSRT/JSRT-03-00100.pdfTest |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.477A7534 |
| قاعدة البيانات: |
BASE |
