دورية أكاديمية
Insulin-like growth factor I modulates sleep through hypothalamic orexin neurons
| العنوان: | Insulin-like growth factor I modulates sleep through hypothalamic orexin neurons |
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| المؤلفون: | Zegarra-Valdivia, J.A., Pignatelli Garrigos, Jaime, Fernandez de Sevilla, M.E., Fernandez, A.M., Munive, V., Martinez-Rachadell, Laura, Núñez, Ángel, Torres Alemán, Ignacio |
| المساهمون: | Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Agencia Estatal de Investigación (España), Federación Española de Enfermedades Raras, Ministerio de Economía y Empresa (España), Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (Perú), Fondo Nacional de Desarrollo Científico, Tecnológico y de Información Tecnológica (Perú) |
| بيانات النشر: | Federation of American Societies for Experimental Biology |
| سنة النشر: | 2020 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | GF-I, orexin neurons, sleep |
| الوصف: | Although sleep disturbances are common co-morbidities of metabolic diseases, the underlying processes linking both are not yet fully defined. Changes in the duration of sleep are paralleled by changes in the levels of insulin-like growth factor-I (IGF-I), an anabolic hormone that shows a circadian pattern in the circulation and activity-dependent entrance in the brain. However, the specific role, if any, of IGF-I in this universal homeostatic process remains poorly understood. We now report that the activity of orexin neurons, a discrete cell population in the lateral hypothalamus that is involved in the circadian sleep/wake cycle and arousal, is modulated by IGF-I. Furthermore, mice with blunted IGF-I receptor activity in orexin neurons have lower levels of orexin in the hypothalamus, show altered electro-corticographic patterns with predominant slow wave activity, and reduced onset-sleep latency. Collectively, these results extend the role in the brain of this pleiotropic growth factor to shaping sleep architecture through the regulation of orexin neurons. We speculate that poor sleep quality associated to diverse conditions may be related to disturbed brain IGF-I input to orexin neurons. ; This work was funded by a grant from Ciberned, and from SAF2016-76462 (AEI/FEDER; MINECO). JA Zegarra-Valdivia acknowledges the financial support of the National Council of Science, Technology and Technological Innovation (CONCYTEC, Perú) through the National Fund for Scientific and Technological Development (FONDECYT, Perú). We are thankful to M. Garcia for technical support. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1530-6860 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/76462; Publisher's version; http://dx.doi.org/10.1096/fj.202001281RRTest; Sí; FASEB Journal 34: 15975- 15990 (2020); http://hdl.handle.net/10261/228969Test; http://dx.doi.org/10.13039/501100011033Test; http://dx.doi.org/10.13039/501100002924Test; http://dx.doi.org/10.13039/501100010747Test |
| DOI: | 10.1096/fj.202001281RR |
| DOI: | 10.13039/501100011033 |
| DOI: | 10.13039/501100002924 |
| DOI: | 10.13039/501100010747 |
| الإتاحة: | https://doi.org/10.1096/fj.202001281RRTest https://doi.org/10.13039/501100011033Test https://doi.org/10.13039/501100002924Test https://doi.org/10.13039/501100010747Test http://hdl.handle.net/10261/228969Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.19342F7 |
| قاعدة البيانات: | BASE |
| تدمد: | 15306860 |
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| DOI: | 10.1096/fj.202001281RR |