نتائج البحث - "c/ebp homologous protein"

1

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

المؤلفون: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

مصطلحات موضوعية: LOX1, lectin-like oxidized LDL receptor 1, BUN, blood urea nitrogen, TGBM, thickness of glomerular basement membrane, NQO1, NAD(P)H:quinone oxidoreductase 1, STAT, signal transducers and activators of transcription, N/O, not observed, p62, sequestosome 1 protein, p-IRS1, phospho-IRS1, Review, NOX-4, nicotinamide adenine dinucleotide phosphate-oxidase-4, OCP, oxidative carbonyl protein, Traditional Chinese medicine, AGEs, advanced glycation end-products, N/A, not applicable, TRAF5, tumor-necrosis factor receptor-associated factor 5, Health problems, 0302 clinical medicine, ESRD, end-stage renal disease, LDL, low-density lipoprotein, BMP-7, bone morphogenetic protein-7, TGFβR-I/II, TGF-β receptor I/II, Medicine, P70S6K, 70-kDa ribosomal protein S6 kinase, General Pharmacology, Toxicology and Pharmaceutics, SOCS, suppressor of cytokine signaling proteins, HO-1, heme oxygenase-1, 0303 health sciences, TG, triglyceride, BW, body weight, HDL-C, high density lipoprotein-cholesterol, RASI, renin-angiotensin system inhibitor, ATK, protein kinase B, TBARS, thiobarbituric acid-reactive substance, BCL-XL, B-cell lymphoma-extra large, Gαq, Gq protein alpha subunit, GCK, glucokinase, PI3K, phosphatidylinositol 3 kinases, Systematic review, TLR-2/4, toll-like receptor 2/4, IR, insulin receptor, PERK, protein kinase RNA-like eukaryotic initiation factor 2A kinase, 030220 oncology & carcinogenesis, CRP, C-reactive protein, IRS, insulin receptor substrate, AM, mesangial area, JAK, Janus kinase, FBG, fasting blood glucose, ETAR, endothelium A receptor, LDL-C, low density lipoprotein-cholesterol, CD2AP, CD2-associated protein, eIF2α, eukaryotic initiation factor 2α, RM1-950, mTOR, mammalian target of rapamycin, CHOP, C/EBP homologous protein, STZ, streptozotocin, 03 medical and health sciences, ADE, adverse event, PKC, protein kinase C, LC3, microtubule-associated protein light chain 3, ORP150, 150-kDa oxygen-regulated protein, PGE2, prostaglandin E2, IL-1β/6, interleukin 1β/6, Diabetic kidney disease, IGF-1, insulin-like growth factor 1, EP, E-prostanoid receptor, FN, fibronectin, eGFR, estimated GFR, MDA, malondialdehyde, Chinese medicine, MMP-2, matrix metallopeptidase 2, XBP-1, spliced X box-binding protein 1, TGF-β, tumor growth factor β, GRB 10, growth factor receptor-bound protein 10, medicine.disease, Clinical trial, GRP78, glucose-regulated protein 78, UP, urinary protein, IGF-1R, insulin-like growth factor 1 receptor, ACEI, angiotensin-converting enzyme inhibitor, BCL-2, B-cell lymphoma 2, EMT, epithelial-to-mesenchymal transition, MAPK, mitogen-activated protein kinase, MYD88, myeloid differentiation primary response 88, PBG, postprandial blood glucose, RCT, randomized clinical trial, N/R, not reported, COL-I/IV, collagen I/IV, PINK1, PTEN-induced putative kinase 1, UACR, urinary albumin to creatinine ratio, C, control group, Diabetic nephropathy, GPX, glutathione peroxidase, ICAM-1, intercellular adhesion molecule-1, Bioinformatics, VCAM-1, vascular cell adhesion molecule-1, AMPKα, adenosine monophosphate-activated protein kinase α, DM, diabetes mellitus, TFEB, transcription factor EB, TNF-α, tumor necrosis factor α, Molecular target, IKK-β, IκB kinase β, Signaling pathway, GLUT4, glucose transporter type 4, BAX, BCL-2-associated X protein, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, PARP, poly(ADP-Ribose) polymerase, SMURF-2, SMAD ubiquitination regulatory factor 2, AREs, antioxidant response elements, MD, mean difference, SMAD, small mothers against decapentaplegic, MCP-1, monocyte chemotactic protein-1, VEGF, vascular endothelial growth factor, cAMP, cyclic adenosine monophosphate, ARB, angiotensin receptor blocker, PAI-1, plasminogen activator inhibitor-1, SMD, standard mean difference, JNK, c-Jun N-terminal kinase, NRF2, nuclear factor erythroid 2-related factor 2, IκB-α, inhibitory protein α, Herbal medicine, TCM, traditional Chinese medicine, DG, glomerular diameter, GSK-3, glycogen synthase kinase 3, SIRT1, sirtuin 1, D, duration, HbA1c, glycosylated hemoglobin, WMD, weight mean difference, CTGF, connective tissue growth factor, ER, endoplasmic reticulum, DN, diabetic nephropathy, ROS, reactive oxygen species, CCR, creatinine clearance rate, SOD, superoxide dismutase, Diabetes mellitus, PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1α, ET-1, endothelin-1, UMA, urinary microalbumin, SCr, serum creatinine, IRE-1α, inositol-requiring enzyme-1α, 030304 developmental biology, TII, tubulointerstitial injury index, RAGE, receptors of AGE, business.industry, GFR, glomerular filtration rate, PTEN, phosphatase and tensin homolog, CI, confidence interval, TC, total cholesterol, SD-rat, Sprague–Dawley rat, UAER, urinary albumin excretion rate, DKD, diabetic kidney disease, T, treatment group, Molecular targets, Therapeutics. Pharmacology, α-SMA, α smooth muscle actin, SD, standard deviation, business, DAG, diacylglycerol, GCLC, glutamate-cysteine ligase catalytic subunit, Kidney disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517Test
https://doi.org/10.1016/j.apsb.2020.12.020Test

2

miRNA 5100 Exacerbated Cisplatin Chemoresistance in Lung Cancer via Suppressing C/EBP Homologous Protein (CHOP) Expression

المؤلفون: Dandan Huang, Jili Zou, Fang Zhang

المصدر: Journal of Biomaterials and Tissue Engineering. 11:59-66

مصطلحات موضوعية: Cisplatin, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, CHOP, Biology, medicine.disease, microRNA, Cancer research, medicine, Lung cancer, C-EBP Homologous Protein, Biotechnology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ca0eae40e5da8255a209a876b8cee3a5Test
https://doi.org/10.1166/jbt.2021.2641Test

3

Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

المؤلفون: Mingyang Shao, Qing Xu, Menglin Chen, Xiaoyue Cao, Chuan Li, Hong Bu, Yuwei Chen, Yuke Shu, Zhenru Wu, Gang Guo, Yuping Gong, Yongjie Zhou, Yujun Shi

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 633-651 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Adenosine, FoxM1, forkhead box M1, IRE1α, inositol requiring enzyme 1 alpha, XBP1, X-box-binding protein 1, STAT, signal transducers and activators of transcription, RNA Stability, Mettl3, methyltransferase-like 3, Alkbh5, ALKB family member 5 protein, Apoptosis, RC799-869, AST, aspartate aminotransferase, WTAP, Wilms’ tumor 1-associated protein, Endoplasmic Reticulum, UPR, unfolded protein response, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Homeostasis, TUDCA, tauroursodeoxycholate, BrdU, 5-bromo-2-deoxyuridine, eIF2α, eukaryotic translation initiator factor 2α, Original Research, Mice, Knockout, N6-methyladenosine, Chemistry, Gastroenterology, PI3K, phosphatidylinositol 3-kinase, Methylation, Diseases of the digestive system. Gastroenterology, Cell cycle, Endoplasmic Reticulum Stress, Liver regeneration, Cell biology, UTR, untranslated region, medicine.anatomical_structure, Liver, PHx, partial hepatectomy, Organ Specificity, Hepatocyte, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, FTO, fat mass and obesity-associated protein, ATF6, activating transcription factor 6, AMPK, adenosine 5′-monophosphate-activated protein kinase, JAK, janus kinase, ER, endoplasmic reticulum, Taurochenodeoxycholic Acid, PAS, periodic acid–Schiff, Necrosis, 03 medical and health sciences, ALT, alanine aminotransferase, TM, tunicamycin, medicine, Act D, actinomycin, Animals, Hepatectomy, RNA, Messenger, Cell Proliferation, Messenger RNA, Hepatology, Endoplasmic reticulum, CDS, coding sequence, Mettl14, Methyltransferases, FC, fold change, m6A, N6-methyladenosine, WT, wild-type, Liver Regeneration, m6A-seq, m6A sequencing, 030104 developmental biology, MRNA Sequencing, Hepatocytes, Unfolded protein response, EIF3A, eukaryotic translation initiation factor 3 subunit A, HCC, hepatocellular carcinoma, Peptides, Transcriptome, PERK, protein kinase R-like endoplasmic reticulum kinase, Chop, C/EBP-homologous protein, MAPK, mitogen-activated protein kinase, Gene Deletion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07948b84c6263e6b798b7056d5735a81Test
https://doi.org/10.1016/j.jcmgh.2021.04.001Test

4

p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse

المؤلفون: David Hood, Jonathan Memme, Ashley Oliveira

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: p53, muscle atrophy, mitochondrial biogenesis, ATF4, activating transcription factor 4, log2FC, log2 fold change, Biochemistry, mKO, muscle-specific KO, Mice, transcriptomics, 0302 clinical medicine, GSEA, gene set enrichment analysis, PINK1, phosphatase and tensin homolog–induced kinase 1, ClpP, caseinolytic mitochondrial matrix peptidase proteolytic subunit, SirT3, sirtuin 3, TFEB, transcription factor EB, UPRmt, mitochondrial unfolded protein response, PGC-1α, peroxisome proliferator–activated receptor gamma coactivator 1 alpha, 0303 health sciences, mitochondrial quality control, EDL, extensor digitorum longus, Mitophagy, unfolded protein response, LC3, microtubule-associated proteins 1a/1b light chain 3, CtsD, cathepsin D, Denervation, MQC, mitochondrial quality control, mitochondria, Muscular Atrophy, LonP, lon protease homolog, mitochondrial, CON, control, COX, cytochrome c oxidase, SDH, succinate dehydrogenase, lysosome, HSP, heat shock protein, Research Article, DEN, denervated, REVIGO, reduce and visualize Gene Ontology, CHOP, C/EBP homologous protein, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, GO, Gene Ontology, Animals, skeletal muscle, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Atg, autophagy-related protein, TA, tibialis anterior, ATF5, activating transcription factor 5, Prkn, Parkin, TFE3, transcription factor E3, Cell Biology, p62, sequestosome-1, Mitochondria, Muscle, mtDNA, mitochondrial DNA, Tumor Suppressor Protein p53, qPCR, quantitative PCR, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3a97e49a86a03392f94c39be1c648Test
https://pubmed.ncbi.nlm.nih.gov/34958797Test

5

Autophagy triggers endoplasmic reticulum stress and C/EBP homologous protein-mediated apoptosis in OGD/R-treated neurons in a caspase-12-independent manner

المؤلفون: Ying Tian, Liang Wang, Zhiqiang Qiu, Yulun Xu, Rongrong Hua

المصدر: Journal of neurophysiology. 126(5)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01520c3c74a89c8c48b181b13bdea1bTest
https://pubmed.ncbi.nlm.nih.gov/34644182Test

6

C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS‐induced cell apoptosis

المؤلفون: Dingdong Liu, Li Yu, Zhencan Shi, Yugang Qiu, Yafei Li, Kai Zhang, Zhangfa Song, Zhenyu Ju, Ying Luo, Daojun Diao, Yanan Zhao

المصدر: Aging Cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e158ccd01e116072cea7c6d7b077fda6Test
https://doi.org/10.1111/acel.13382Test

7

Fatty Acids Inhibit LAMP2-Mediated Autophagy Flux via Activating ER Stress Pathway in Alcohol-Related Liver Disease

المؤلفون: Zhanxiang Zhou, Wei Zhong, Liuyi Hao, Haibo Dong, Tianjiao Li, Ruichao Yue, Wei Guo, Xinguo Sun

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1599-1615 (2021)

مصطلحات موضوعية: ATF4, activating transcription factor 4, DGAT1, acyl-CoA:diacylglycerol acyltransferase 1, MPO, myeloperoxidase, SAH, severe alcoholic hepatitis, RC799-869, AST, aspartate aminotransferase, PF, pair-fed, Mice, Liver Function Tests, Lipid droplet, ALD, alcohol-related liver disease, Original Research, DGAT1, Liver injury, Mice, Knockout, Free Fatty Acid, LAMP2, LDH, lactate dehydrogenase, TG, triglyceride, Chemistry, Fatty Acids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Endoplasmic Reticulum Stress, Cell biology, medicine.anatomical_structure, Lipotoxicity, Hepatocyte, Disease Susceptibility, Signal Transduction, Programmed cell death, LAMP2, lysosome-associated membrane protein 2, CHOP, C/EBP homologous protein, Models, Biological, ER, endoplasmic reticulum, PA, palmitic acid, Alcohol-Induced Liver Injury, Lysosomal-Associated Membrane Protein 2, ALT, alanine aminotransferase, FFA, free fatty acid, medicine, Autophagy, Animals, Humans, LC3II, microtubule-associated protein 1A/1B-light chain 3 II, Diacylglycerol O-Acyltransferase, Liver Diseases, Alcoholic, AF, alcohol-fed, PPARα, peroxisome proliferator-activated receptor α, Hepatology, OA, oleic acid, VLDL, very-low-density lipoprotein, medicine.disease, Lipid Metabolism, Disease Models, Animal, Unfolded protein response, Hepatocytes, Biomarkers