Genomic reconstruction of the SARS-CoV-2 epidemic in England
| العنوان: | Genomic reconstruction of the SARS-CoV-2 epidemic in England |
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| المؤلفون: | Nicola De Maio, Cristina V. Ariani, Frank Schwach, Ewan Birney, Thuy Nguyen, David A. Jackson, Sónia Gonçalves, Moritz Gerstung, Inigo Martincorena, Callum Saint, Matthew Sinnott, Meera Chand, Nick Goldman, Ian Johnston, Ian Harrison, Jeffrey C. Barrett, Jasmina Panovska-Griffiths, Erik M. Volz, Theo Sanderson, Sebastian Funk, Harald Vöhringer, Dominic P. Kwiatkowski, Joel Hellewell, John Sillitoe, Richard Goater, Maria Suciu, Alexander W. Jung |
| المساهمون: | Sinnott, Matthew [0000-0002-3054-7846], Goater, Richard [0000-0001-9954-841X], Harrison, Ian [0000-0003-4117-961X], Hellewell, Joel [0000-0003-2683-0849], Jackson, David K [0000-0002-8090-9462], Saint, Callum [0000-0001-8720-9736], Goldman, Nick [0000-0001-8486-2211], Panovska-Griffiths, Jasmina [0000-0002-7720-1121], Birney, Ewan [0000-0001-8314-8497], Volz, Erik [0000-0001-6268-8937], Funk, Sebastian [0000-0002-2842-3406], Kwiatkowski, Dominic [0000-0002-5023-0176], Martincorena, Inigo [0000-0003-1122-4416], Barrett, Jeffrey C [0000-0002-1152-370X], Gerstung, Moritz [0000-0001-6709-963X], Apollo - University of Cambridge Repository |
| المصدر: | Nature, vol 600, iss 7889 |
| بيانات النشر: | eScholarship, University of California, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, Wellcome Sanger Institute Covid-19 Surveillance Team, Coronavirus disease 2019 (COVID-19), General Science & Technology, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Lineage (evolution), Zoology, Genome, Viral, Biology, COVID-19 Genomics UK (COG-UK) Consortium, Spatio-Temporal Analysis, Pandemic, Genetics, Humans, Viral, Lung, Molecular Epidemiology, Genome, SARS-CoV-2, Prevention, Wellcome Sanger Institute COVID-19 Surveillance Team, COVID-19, Genomics, Spike Glycoprotein, Coronavirus, Emerging Infectious Diseases, Infectious Diseases, Good Health and Well Being, Amino Acid Substitution, England, Spike Glycoprotein, Coronavirus, Quarantine, Mutation, Epidemiological Monitoring |
| الوصف: | The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance datagenerated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021. |
| وصف الملف: | application/pdf; application/octet-stream; application/zip; text/xml |
| تدمد: | 0028-0836 1476-4687 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c115469b43cda5acae129df006f7d5Test https://escholarship.org/uc/item/2x40z5h4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72c115469b43cda5acae129df006f7d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00280836 14764687 |
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