المؤلفون: Alves Ribeiro, J., Santos, R., Pinheiro, F., Pais, A., Cardoso, J.

المصدر: XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

الوصف: Geomagnetically Induced currents (GICs) arise from rapid geomagnetic field variations caused by highly energized solar wind. These currents flow in the Earth's surface and along conductive man-made infrastructures galvanically connected to Earth, as power systems. Consequently, electric power stability can be compromised and, in extreme cases, can lead to blackouts.Accurate GIC simulations require knowledge of the geomagnetic field variations, the Earth's conductivity, and power grid parameters. To accurately estimate the magnitude of GICs, we need to understand how the conductivity model is affected by geological structures. Testing various conductivity models (e.g., tighter magnetotelluric sounding grid and presence/absence of specific geological structures) can determine the sensitivity of our GIC calculations to different geological structures. This information is vital in accessing the realistic hazard to specific substations of power grids.Additionally, GIC measurements can be used to improve the conductivity model. Since August 30th 2021, we have been monitoring GIC currents flowing through a transformer's neutral at Paraimo (SPI) substation. Comparing with simulations, we noticed a deterioration of correlation at lower frequencies, indicating imprecision of our conductivity model for deeper layers. Given the availability of geomagnetic (at the nearby observatory of Coimbra) and GIC measurements, we can carry on different tests and estimate a local surface impedance. Then, we can invert it to try to extract the 1D ground conductivity structure at depth, using standard MT tools [1,2].[1] 10.1109/UPEC50034.2021.9548157[2] https://doi.org/10.1186/BF03352040Test
The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ffae430726520a3a4d74ee312e7b7dTest

المؤلفون: Ali, R., Pinheiro, F. A., Dutra, R. S., Alegre, T. P. Mayer, Wiederhecker, G. S.

مصطلحات موضوعية: Quantitative Biology::Biomolecules, High Energy Physics::Lattice, Physics::Optics, FOS: Physical sciences, Physics - Optics, Optics (physics.optics)

الوصف: We propose a gain-assisted enantioselective scheme in dye-doped chiral particles, demonstrating optical pulling and pushing forces that can be tuned using externally controllable parameters. By controlling the concentration of dye molecules and pumping rate, we achieve all-optical chiral resolution of racemic mixtures and enantioselection of small dipolar chiral particles without relying on interference. This scheme is applicable to both lossless and lossy plasmonic chiral particles, making it a promising approach for chiral sensing, drug discovery, and molecular separation.
Comment: 6 pages, 6 figures

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba96a34035b846b00ae55d1cbe9c41d9Test

المؤلفون: Ali, R., Dutra, R. S., Pinheiro, F. A., Neto, P. A. Maia

مصطلحات موضوعية: Quantitative Biology::Biomolecules, High Energy Physics::Lattice, Physics::Optics, FOS: Physical sciences, Physics - Optics, Optics (physics.optics)

الوصف: We put forward a novel, twofold scheme that enables at the same time all-optical enantioselection and sorting of single multipolar chiral microspheres based on optical pulling forces exerted by two non-collinear, nonstructured, circularly-polarized light sources. Our chiral resolution method can be externally controlled by varying the angle between their incident wavevectors, allowing for a fine-tuning of the range of chiral indices for enantioselection. Enantioselectivity is achieved by choosing angles such that only particles with the same handedness of the light sources are pulled. This proposal allows one to achieve all-optical sorting of chiral microspheres with arbitrarily small chiral parameters, thus outperforming current optical methods.
Comment: 4 pages 4 Figures

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689b17a6b64bcbd332c886cdcab7b20Test

المؤلفون: Tapia G. I. Medina, Pinheiro F. Ricardo, Pereira C. Joale

المصدر: SN Applied Sciences. 2

مصطلحات موضوعية: Computer science, business.industry, General Chemical Engineering, General Engineering, Scheduling (production processes), General Physics and Astronomy, Net present value, Sizing, Electricity generation, Biogas, General Earth and Planetary Sciences, General Materials Science, Sewage treatment, Profitability index, Cost benefit, Process engineering, business, General Environmental Science

الوصف: We developed the generator scheduling methodology proposed in this work to make electricity generation more efficient in installations that have a variable biogas production profile. The method was applied at the Baldo/CAERN sewage treatment plant. In this application we retrieved a Net Present Value of R$ 46,356,973,80 for the generation system during 20 years, with a Cost Benefit Index of 2.85, which showed the large financial profitability of the project, derived from the efficient usage of the biogas provided by the developed methodology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::da1637edcba6035c527cf23d1cf36f60Test
https://doi.org/10.1007/s42452-020-1968-0Test

المؤلفون: Peña-Díaz, S., Pujols, J., Pinheiro, F., Santos, J., Pallarés, I., Navarro, S., Conde-Gimenez, M., García, J., Salvatella, X., Dalfó, E., Sancho, J., Ventura, S.

المصدر: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

مصطلحات موضوعية: mental disorders

الوصف: Synucleinopathies are a group of disorders characterized by the accumulation of a-Synuclein amyloid inclusions in the brain. Preventing a-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a promising approach for therapeutic intervention in these pathologies. A high-throughput screening initiative allowed us to discover ZPDm, the smallest active molecule in a library of more than 14.000 compounds. Although the ZPDm structure is highly related to that of the previously described ZPD-2 aggregation inhibitor, we show here that their mechanisms of action are entirely different. ZPDm inhibits the aggregation of wild-type, A30P, and H50Q a-Synuclein variants in vitro and interferes with a-Synuclein seeded aggregation in protein misfolding cyclic amplification assays. However, ZPDm distinctive feature is its strong potency to dismantle preformed a-Synuclein amyloid fibrils. Studies in a Caenorhabditis elegans model of Parkinson’s Disease, prove that these in vitro properties are translated into a significant reduction in the accumulation of a-Synuclein inclusions in ZPDm treated animals. Together with previous data, the present work illustrates how different chemical groups on top of a common molecular scaffold can result in divergent but complementary anti-amyloid activities.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1fa24432de7209d453a70566751ce8eaTest
http://zaguan.unizar.es/record/97191Test

المؤلفون: Ali, Rfaqat, Dutra, R. S., Pinheiro, F. A., Rosa, F. S. S., Neto, P. A. Maia

مصطلحات موضوعية: Physics::Optics, FOS: Physical sciences, Physics - Optics, Optics (physics.optics)

الوصف: We report for the first time the theory of optical tweezers of spherical dielectric particles embedded in a chiral medium. We develop a partial-wave (Mie) expansion to calculate the optical force acting on a dielectric microsphere illuminated by a circularly-polarized, highly focused laser beam. When choosing a polarization with the same handedness of the medium, the axial trap stability is improved, thus allowing for tweezing of high-refractive-index particles. When the particle is displaced off-axis by an external force, its equilibrium position is rotated around the optical axis by the mechanical effect of an optical torque. Both the optical torque and the angle of rotation are greatly enhanced in the presence of a chiral host medium when considering radii a few times larger than the wavelength. In this range, the angle of rotation depends strongly on the microsphere radius and the chirality parameter of the host medium, opening the way for a quantitative characterization of both parameters. Measurable angles are predicted even in the case of naturally occurring chiral solutes, allowing for a novel all-optical method to locally probe the chiral response at the nanoscale.
Comment: This work is published in Scientific Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136007644c5900b205f5ea703b0c3e6bTest

المؤلفون: Vesentini, Giovana [UNESP], Barbosa, Angélica M.P. [UNESP], Damasceno, Débora C. [UNESP], Marini, Gabriela [UNESP], Piculo, Fernanda [UNESP], Matheus, Selma M.M. [UNESP], Hallur, Raghavendra L.S. [UNESP], Nunes, Sthefanie K. [UNESP], Catinelli, Bruna B. [UNESP], Magalhães, Claudia G. [UNESP], Costa, Roberto [UNESP], Abbade, Joelcio F. [UNESP], Corrente, José E. [UNESP], Calderon, Iracema M.P. [UNESP], Rudge, Marilza V.C. [UNESP], Souza, F. P. [UNESP], Hijas, A., Sobrevia, L., Palma, M. S. [UNESP], Graeff, C. F.O. [UNESP], Arni, R. K. [UNESP], Herculano, R. D. [UNESP], Salvadori, D. F. [UNESP], Dal Pai Silva, M. [UNESP], Lima, S. A.M. [UNESP], Emanueli, C., Felisbino, S. [UNESP], Barbosa, W. [UNESP], Atallah, A., Girão, M. J.B., Di Bella, Z., Uchoa, S. M., Payão, S., Berghman, B., De Bie, R., Junginger, B., Alves, F. C.B. [UNESP], Rossignoli, P. S. [UNESP], Prudencio, C. B. [UNESP], Orlandi, M. I.G. [UNESP], Gonçalves, M. I. [UNESP], Sarmento, B. V. [UNESP], Pinheiro, F. A. [UNESP], Sartorão, C. I. [UNESP], Quiroz, S. B.C.V. [UNESP], Reyes, D. R.A. [UNESP], Enriquez, E. M.A. [UNESP], Oliveira, R. G. [UNESP], Floriano, J. F. [UNESP], Marcondes, J. P.C. [UNESP], Costa, S. M.B. [UNESP], Dangió, T. D. [UNESP], Pascon, T. [UNESP], Melo, J. V.F. [UNESP], Takano, L. [UNESP], Reis, F. V.D.S. [UNESP], Caldeirão, T. D. [UNESP], Carr, A. M. [UNESP], Garcia, G. A. [UNESP], Rabadan, G. B. [UNESP], Bassin, H. C.M., Suyama, K. S. [UNESP], Damasceno, L. N. [UNESP], Takemoto, M. L.S. [UNESP], Menezes, M. D. [UNESP], Bussaneli, D. G. [UNESP], Nogueira, V. K.C. [UNESP], Lima, P. R. [UNESP], Lourenço, I. O. [UNESP], Marostica De Sá, J. [UNESP], Megid, R. A. [UNESP], Caruso, I. P. [UNESP], Rasmussen, L. T., Prata, G. M., Arantes, M. A. [UNESP], Ferraz, G. A.R. [UNESP], Camargo, L. P. [UNESP], Kron, M. R. [UNESP], Nunes, H. R.C. [UNESP]

المساهمون: Universidade Estadual Paulista (Unesp), Universidade Sagrado Coração, Case Western Reserve University, Pontificia Universidad Catolica de Chile, Imperial College London, Universidade Federal de São Paulo (UNIFESP), Universidade Católica de Pernambuco, Faculdade de Medicina de Marília, Maastrich University, Charité Universitätsmedizin Berlin, Universidade do Sagrado Coração, Faculdades Integradas de Bauru

المصدر: PLoS ONE
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS ONE, Vol 15, Iss 4, p e0231096 (2020)

مصطلحات موضوعية: Male, Maternal Health, Rectus Abdominis, Biochemistry, 0302 clinical medicine, Endocrinology, Pregnancy, Animal Cells, Medicine and Health Sciences, Rectus abdominis muscle, Musculoskeletal System, Abdominal Muscles, Glucose tolerance test, 030219 obstetrics & reproductive medicine, Multidisciplinary, medicine.diagnostic_test, Muscles, Obstetrics and Gynecology, Animal Models, Gestational diabetes, Experimental Organism Systems, Immunohistochemistry, Medicine, Female, Anatomy, Cellular Types, medicine.drug, Research Article, Adult, medicine.medical_specialty, Endocrine Disorders, Science, 030209 endocrinology & metabolism, Research and Analysis Methods, Muscle Fibers, 03 medical and health sciences, Fetus, Internal medicine, Diabetes mellitus, medicine, Diabetes Mellitus, Animals, Humans, Rats, Wistar, Gestational Diabetes, business.industry, Body Weight, Biology and Life Sciences, Proteins, Cell Biology, Glucose Tolerance Test, Skeletal Muscle Fibers, medicine.disease, Streptozotocin, Diabetes, Gestational, Disease Models, Animal, Skeletal Muscles, Metabolic Disorders, Animal Studies, Women's Health, business, Collagens

الوصف: Made available in DSpace on 2020-12-12T02:01:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01 Associação Brasileira de Saúde Coletiva Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background and objective In the present study, we compared the effect of diabetic pregnancy on the rectus abdominis muscle (RAM) in humans and rats. We hypothesized that our animal model could provide valuable information about alterations in the RAM of women with Gestational Diabetes (GDM). Method Newborns female rats (n = 10/group) were administered streptozotocin (100 mg/kg body weight) subcutaneously and were mated on reaching adulthood, to develop the mild hyperglycemic pregnant (MHP) rat model. At the end of pregnancy, the mothers were sacrificed, and the RAM tissue was collected. Pregnant women without GDM (non-GDM group; n = 10) and those diagnosed with GDM (GDM group; n = 8) and undergoing treatment were recruited, and RAM samples were obtained at C-section. The RAM architecture and the distribution of the fast and slow fibers and collagen were studied by immunohistochemistry. Results No statistically significant differences in the maternal and fetal characters were observed between the groups in both rats and women. However, significant changes in RAM architecture were observed. Diabetes in pregnancy increased the abundance of slow fibers and decreased fast fiber number and area in both rats and women. A decrease in collagen distribution was observed in GDM women; however, a similar change was not observed in the MHP rats. Conclusion Our results indicated that pregnancy- associated diabetes- induced similar structural adaptations in the RAM of women and rats with slight alterations in fiber type number and area. These findings suggest that the MHP rat model can be used for studying the effects of pregnancy-associated diabetes on the fiber structure of RAM. Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Health Sciences Universidade Sagrado Coração Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista Case Western Reserve University Pontificia Universidad Catolica de Chile Imperial College London Universidade Federal de São Paulo Universidade Católica de Pernambuco Faculdade de Medicina de Marília Maastrich University Charité Universitätsmedizin Berlin Universidade do Sagrado Coração Faculdades Integradas de Bauru Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ. Estadual Paulista-UNESP Department of Gynecology and Obstetrics São Paulo State University (UNESP) Botucatu Medical School Department of Physiotherapy and Occupational Therapy São Paulo State University (UNESP) School of Philosophy and Sciences Department of Anatomy São Paulo State University (UNESP) Institute of Biosciences Department of Biostatistics São Paulo State University (UNESP) Bioscience Institute Universidade Estadual Paulista FAPESP: #2014/26852-6 FAPESP: #2016/01743-5 FAPESP: #2016/09710-9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a589bc04ca722e3f850e7ccfc4f1be1bTest
https://pubmed.ncbi.nlm.nih.gov/32243473Test

المؤلفون: Angelis, F. M. D, Pinheiro, F. A., Impens, F.

مصطلحات موضوعية: Quantum Physics, FOS: Physical sciences, Quantum Physics (quant-ph)

الوصف: We investigate the influence of critical phenomena on two distinct physical processes: the center-of-mass decoherence of a single emitter, and the collective radiation of two emitters. We address these different physical mechanisms with an unified formalism relying on standard perturbation theory. We decompose the decoherence and the collective emission rates as a sum of two contributions, accounting for the spontaneous emission and for interference effects respectively. The former is enhanced by the Purcell effect when the material is in the vicinity of the emitter(s). The latter, associated to quantum interferences, experiences a "sudden death" near the critical point of the phase transition. Our findings unveil the interplay between the Purcell and collective effects and its dependence on metal-insulator transitions. We discuss two specific examples of phase transitions: the percolation transition in a metal-dielectric composite, and the metal-insulator transition in VO2. In the latter, decoherence and collective emission rates exhibit a characteristic hysteresis that strongly depends on the material temperature. These results, based on experimental data, suggest that VO2 could be explored as a versatile material platform where decoherence and collective emission can be tuned by varying the temperature.
Comment: 9 pages, 7 figures

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c09e6e49586dca7cb582bd4d30ff6b2Test

المؤلفون: Pujols, J., Pena-Diaz, S., Lazaro, D.F., Peccati, F., Pinheiro, F., Gonzalez, D., Carija, A., Navarro, S., Conde-Gimenez, M., Garcia, J., Guardiola, S., Giralt, E., Salvatella, X., Sancho, J., Sodupe, M., Outeiro, T.F., Dalfo, E., Ventura, S.

المصدر: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname

مصطلحات موضوعية: nervous system, nervous system diseases

الوصف: Parkinson''s disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of intracellular protein inclusions, known as Lewy bodies and Lewy neurites, which are mainly composed of alpha-synuclein. Here, we exploited a high-throughput screening methodology to identify a small molecule (SynuClean-D) able to inhibit alpha-synuclein aggregation. SynuClean-D significantly reduces the in vitro aggregation of wildtype alpha-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. This compound prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of alpha-synuclein inclusions in human neuroglioma cells. Computational analysis suggests that SynuClean-D can bind to cavities in mature alpha-synuclein fibrils and, indeed, it displays a strong fibril disaggregation activity. The treatment with SynuClean-D of two PD Caenorhabditis elegans models, expressing alpha-synuclein either in muscle or in dopaminergic neurons, significantly reduces the toxicity exerted by alpha- synuclein. SynuClean-D-treated worms show decreased alpha-synuclein aggregation in muscle and a concomitant motility recovery. More importantly, this compound is able to rescue dopaminergic neurons from alpha-synuclein-induced degeneration. Overall, SynuClean-D appears to be a promising molecule for therapeutic intervention in Parkinson's disease.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b757b2e865933ad09bd19263e9cabf1cTest
http://zaguan.unizar.es/record/75810Test

المؤلفون: Weiss, W, Aerts, C, Aigrain, S, Alecian, G, Antonello, E, Baglin, A, Bazot, M, Collier-Cameron, A, Charpinet, S, Gamarova, A, Handler, G, Hatzes, A, Hubert, A, Lammer, H, Lebzelter, T, Maceroni, C, Marconi, M, de Martino, D, Janot-Pacheco, E, Pagano, I, Paunzen, E, Pinheiro, F, Poretti, E, Ribas, I, Ripepi, V

الوصف: Space experiments which are aiming towards astero-seismology and the detection of exoplanets, like COROT or MOST, Eddington and Kepler, are designed to deliver high precision photometric data. Obviously, the they can be used also for other purposes than the primary science goals and in addition many other targets can or will be automatically observed simultaneously with the primary targets. As a consequence, fascinating possibilities for additional (parallel, secondary) science projects emerge. For COROT a dedicated working group was thus established with the goal to contribute any useful information which may optimize the scientific output of the mission.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______1064::7442f678d6a389eede110c265ad06eebTest
https://ora.ox.ac.uk/objects/uuid:7d7a1e33-e087-4de2-b7e2-8924478308ecTest