Effectiveness and toxicity of lenvatinib in refractory thyroid cancer: Dutch real-life data
| العنوان: | Effectiveness and toxicity of lenvatinib in refractory thyroid cancer: Dutch real-life data |
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| المؤلفون: | A. N. A. van der Horst-Schrivers, Ellen Kapiteijn, K R M Ferrier, M D Aydemirli, Juliette Zwaveling, Thera P. Links, Rolf H.H. Groenwold, K E Broekman, Petronella B. Ottevanger |
| المساهمون: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE) |
| المصدر: | European Journal of Endocrinology, 182, 2, pp. 131-138 European Journal of Endocrinology, 182, 131-138 European Journal of Endocrinology, 182(2), 131-138. BIOSCIENTIFICA LTD |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Population, Gallbladder disease, 030209 endocrinology & metabolism, Antineoplastic Agents, Kaplan-Meier Estimate, Disease-Free Survival, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, All institutes and research themes of the Radboud University Medical Center, Internal medicine, 80 and over, Medicine, Humans, Thyroid Neoplasms, education, Phenylurea Compounds/adverse effects, Thyroid cancer, Aged, Quinolines/adverse effects, Retrospective Studies, Response rate (survey), Aged, 80 and over, education.field_of_study, business.industry, Phenylurea Compounds, Antineoplastic Agents/therapeutic use, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Confidence interval, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], chemistry, 030220 oncology & carcinogenesis, Quinolines, Population study, Female, Thyroid Neoplasms/drug therapy, business, Lenvatinib |
| الوصف: | Objective The SELECT trial showed progression-free survival (PFS) benefit for lenvatinib for advanced radioiodine-refractory differentiated thyroid cancer (RAI-refractory or RR-DTC) patients, on which current clinical practice is based. We assessed whether the effectiveness and toxicity of lenvatinib in real-life clinical practice in the Netherlands were comparable to the pivotal SELECT trial. Methods From three Dutch centres Electronic Health Records (EHRs) of patients treated in the lenvatinib compassionate use program or as standard of care were reviewed and checked for SELECT eligibility criteria. Baseline characteristics, safety, and efficacy measures were compared and PFS and overall survival (OS) were calculated. Furthermore, PFS was compared to estimates of PFS reported in other studies. Results A total of 39 DTC patients with a median age of 62 years were analysed. Of these, 27 patients (69%) did not fulfil the SELECT eligibility criteria. The most common grade ≥3 toxicities were hypertension (n = 11, 28%), diarrhoea (n = 7, 18%), vomiting (n = 4, 10%), and gallbladder disease (n = 3, 8%). Median PFS and median OS were 9.7 (95% confidence interval (CI): 4.0–15.5) and 18.3 (95% CI: 4.9–31.7) months, respectively, response rate was 38% (95% CI: 23–54%). PFS in the Dutch real-life situation was comparable to previous real-life studies, but inferior to PFS as shown in the SELECT trial (P = 0.04). Conclusions PFS in our non-trial population was significantly shorter than in the SELECT trial population. In the interpretation of results, differences in the real-life population and the SELECT study population regarding patient characteristics should be taken into account. |
| وصف الملف: | application/pdf |
| تدمد: | 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8fffdedc9c6ce4b7c6c85c755def11Test https://hdl.handle.net/2066/216644Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea8fffdedc9c6ce4b7c6c85c755def11 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08044643 |
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