COVID-19 Vaccines and Autoimmune Hematologic Disorders
| العنوان: | COVID-19 Vaccines and Autoimmune Hematologic Disorders |
|---|---|
| المؤلفون: | Mingot-Castellano, María Eva, Butta, Nora, Canaro, Mariana, Gómez Del Castillo Solano, María Del Carmen, Sánchez-González, Blanca, Jiménez-Bárcenas, Reyes, Pascual-Izquierdo, Cristina, Caballero-Navarro, Gonzalo, Entrena Ureña, Laura, José González-López, Tomás, On Behalf Of The Gepti |
| المساهمون: | Butta, Nora, Pascual-Izquierdo, Cristina, Butta, Nora [0000-0003-4601-7150], Pascual-Izquierdo, Cristina [0000-0001-5442-4886] |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology, Vaccines, TTP, VITT, Immunology, COVID-19, Catastrophic antiphospholipid syndrome, Infectious Diseases, Antiphospholipid syndrome, Drug Discovery, ITP, Pharmacology (medical), AIHA and Evans syndrome |
| الوصف: | Worldwide vaccination against SARS-CoV-2 has allowed the detection of hematologic autoimmune complications. Adverse events (AEs) of this nature had been previously observed in association with other vaccines. The underlying mechanisms are not totally understood, although mimicry between viral and self-antigens plays a relevant role. It is important to remark that, although the incidence of these AEs is extremely low, their evolution may lead to life-threatening scenarios if treatment is not readily initiated. Hematologic autoimmune AEs have been associated with both mRNA and adenoviral vector-based SARS-CoV-2 vaccines. The main reported entities are secondary immune thrombocytopenia, immune thrombotic thrombocytopenic purpura, autoimmune hemolytic anemia, Evans syndrome, and a newly described disorder, so-called vaccine-induced immune thrombotic thrombocytopenia (VITT). The hallmark of VITT is the presence of anti-platelet factor 4 autoantibodies able to trigger platelet activation. Patients with VITT present with thrombocytopenia and may develop thrombosis in unusual locations such as cerebral beds. The management of hematologic autoimmune AEs does not differ significantly from that of these disorders in a non-vaccine context, thus addressing autoantibody production and bleeding/thromboembolic risk. This means that clinicians must be aware of their distinctive signs in order to diagnose them and initiate treatment as soon as possible. |
| وصف الملف: | application/pdf |
| تدمد: | 2076-393X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0488c0377508276902f532b937a87ce1Test https://doi.org/10.3390/vaccines10060961Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0488c0377508276902f532b937a87ce1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2076393X |
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