Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis
| العنوان: | Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis |
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| المؤلفون: | Tsiara, Chrissa G., Nikolopoulos, Georgios K., Bagos, Pantelis G., Goujard, Cecile, Katzenstein, Terese L., Minga, Albert K., Rouzioux, C., Hatzakis, A. |
| المساهمون: | Nikolopoulos, Georgios K.[0000-0002-3307-0246], Bagos, Pantelis G. [0000-0003-4935-2325] |
| المصدر: | AIDS Research and Human Retroviruses |
| بيانات النشر: | Mary Ann Liebert Inc, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Oncology, Human immunodeficiency virus 1, Disease, Bioinformatics, Viral load, Viral, Disease course, Priority journal, Biological markers, Predictive marker, Virus rna, Medline, Viral Load, Prognosis, Comparative effectiveness, Death, Acquired immunodeficiency syndrome, Infectious Diseases, Acquired immune deficiency syndrome, Virus dna, Meta-analysis, Predictive value of tests, Disease Progression, RNA, Viral, Female, Human, medicine.medical_specialty, Immunology, Predictive value, Bivariate analysis, Article, Acquired immunodeficiency syndrome (AIDS), Predictive Value of Tests, Virology, Internal medicine, medicine, Humans, Acquired Immunodeficiency Syndrome, Disease progression, Intermethod comparison, business.industry, Hiv-1, Dna, medicine.disease, Confidence interval, Relative risk, DNA, Viral, HIV-1, Rna, business, Biomarkers, Meta analysis |
| الوصف: | Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 disease toward acquired immunodeficiency syndrome (AIDS) or death, and to compare the prognostic information obtained by HIV-1 DNA with that derived from plasma HIV-1 RNA. Eligible articles were identified through a comprehensive search of Medline, ISI Web of Science, Scopus, and Google Scholar. The analysis included univariate and bivariate random-effects models. The univariate meta-analysis of six studies involving 1074 participants showed that HIV-1 DNA was a strong predictive marker of AIDS [relative risk (RR): 3.01, 95% confidence interval (CI): 1.88-4.82] and of all-cause mortality (RR: 3.49, 95% CI: 2.06-5.89). The bivariate model using the crude estimates of primary studies indicated that HIV-1 DNA was a significantly better predictor than HIV-1 RNA of either AIDS alone (ratio of RRs=1.47, 95% CI: 1.05-2.07) or of combined (AIDS or death) progression outcomes (ratio of RRs=1.51, 95% CI: 1.11-2.05). HIV-1 DNA is a strong predictor of HIV-1 disease progression. Moreover, there is some evidence that HIV-1 DNA might have better predictive value than plasma HIV-1 RNA. © 2012, Mary Ann Liebert, Inc. 28 4 366 373 |
| تدمد: | 1931-8405 0889-2229 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f502fdb3cdf88788acd38eea1d43a3Test https://doi.org/10.1089/aid.2011.0032Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....26f502fdb3cdf88788acd38eea1d43a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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