نتائج البحث - "Microtubules--metabolism"

المساهمون: Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Celbiologie, Netherlands Institute for Neuroscience (NIN)

المصدر: Neuron
Neuron, 104(2), 305-321.e8. Cell Press
Neuron, 104(2), P305. Cell Press

مصطلحات موضوعية: 0301 basic medicine, Neurons/metabolism, Nerve Growth Factors/metabolism, Axonal Transport, Hippocampus, Microtubules, axon initial segment, Tripartite Motif Proteins, 0302 clinical medicine, Chlorocebus aethiops, CARGO TRANSPORT, Axon, Cytoskeleton, Feedback, Physiological, Neurons, Tumor, Chemistry, General Neuroscience, Neuronal polarity, LOCALIZATION, Endocytosis, Cell biology, medicine.anatomical_structure, Microtubules/metabolism, Axon Initial Segment/metabolism, COS Cells, Hippocampus/cytology, Microtubule-Associated Proteins/metabolism, Tripartite Motif Proteins/metabolism, axonal transport, Microtubule-Associated Proteins, Cell Adhesion Molecules/metabolism, Ankyrins, NEUROFASCIN, Ankyrins/metabolism, Maintenance, Physiological, GIANT ANKYRIN-G, Article, Cell Line, Feedback, microtubules, 03 medical and health sciences, Microtubule, ACTIVITY-DEPENDENT RELOCATION, Cell Line, Tumor, medicine, Compartment (development), endocytosis, Animals, Humans, Nerve Growth Factors, Axon initial segment, Rats, End-binding-protein, 030104 developmental biology, HEK293 Cells, Membrane protein, MOTIF, Axoplasmic transport, Cell Adhesion Molecules, 030217 neurology & neurosurgery

وصف الملف: image/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35ab54b5af356465742c0da08d311b7Test
https://pubmed.ncbi.nlm.nih.gov/31474508Test

6

Tipping microtubule dynamics, one protofilament at a time

المؤلفون: Aher, Amol, Akhmanova, Anna, Sub Cell Biology, Celbiologie

المساهمون: Sub Cell Biology, Celbiologie

المصدر: Current Opinion in Cell Biology, 50, 86. Elsevier

وصف الملف: image/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70931a7988d1655211f91fec0d6fd7Test
https://pubmed.ncbi.nlm.nih.gov/29573640Test

7

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

المؤلفون: Ariane Dimitrov, Raja Bonifay, Cécile Bougeret, Hugo Bousquet, Gaëlle Bressanelli, Arnaud Echard, Vincent Fraisier, Bruno Goud, Olena Pylypenko, Sabine Bardin, Catherine Guillou, Anne Houdusse, Stéphanie Miserey-Lenkei

المساهمون: Mécanismes moléculaires du transport intracellulaire, Compartimentation et dynamique cellulaires (CDC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Motilité structurale, BioImaging Cell and Tissue Core Facility (PICT-IBiSA), Institut Curie [Paris], Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Biokinesis, Trafic membranaire et Division cellulaire - Membrane Traffic and Cell Division, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by an ERC (European Research Council) advanced grant (project 339847 'MYODYN') and an ARC grant (SL220120605302). We acknowledge the recombinant protein and antibody platform of the Institut Curie (http://umr144.curie.fr/en/plateform/protein-and-antibody-laboratory-001279Test) for the production of human recombinant antibodies against Giantin, MHC, and tubulin. The Goud and Houdusse teams are member of Labex CelTisPhyBio (11-LBX-0038) and Idex Paris Sciences et Lettres (ANR-10-IDEX-0001-02 PSL). We thank the beamline scientists of ID29 (ESRF synchrotron) for excellent support during data collection. O.P. was supported by an ARC post-doctoral fellowship. A.H. was supported by grants from the CNRS, ANR-10-MotoRab, ARC PJA 20151203285, ANR15-CE13-0016-01, Ligue Nationale Contre le Cancer., We are grateful to Franck Perez and Ana-Maria Lennon-Duménil (Institut Curie) for generous gifts of reagents, Ana-Maria Lennon-Duménil, Yohanns Bellaïche, and Franck Perez for critical reading of the manuscript and insightful discussions, Carina Santos, Laura Picas and Jean-Baptiste Brault and the Molecular Mechanisms Transport lab for productive discussions. The authors greatly acknowledge the Nikon Imaging Center at Institut Curie-CNRS, the PICT-IBiSA, member of the France-BioImaging national research infrastructure., Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Nature Communications
Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
'Nature Communications ', vol: 8, pages: 1254-1-1254-13 (2017)

مصطلحات موضوعية: 0301 basic medicine, MESH: Golgi Apparatus/metabolism, [SDV]Life Sciences [q-bio], Golgi Apparatus, Kinesins, General Physics and Astronomy, Small GTPases, Microtubules, MESH: Actin Cytoskeleton/metabolism, Myosin, Golgi, MESH: Animals, MESH: Kinesin/metabolism, lcsh:Science, Multidisciplinary, Chemistry, Molecular Motor Proteins, Nonmuscle Myosin Type IIA, Vesicle, MESH: Myosin Heavy Chains/metabolism, Membrane fission, 3. Good health, Transport protein, Actin Cytoskeleton, MESH: rab GTP-Binding Proteins/metabolism, symbols, Kinesin, trans-Golgi Network, MESH: Rats, Science, macromolecular substances, Transport carrier, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, symbols.namesake, Microtubule, Animals, Humans, Actin, MESH: Humans, Myosin Heavy Chains, 030102 biochemistry & molecular biology, Cytoplasmic Vesicles, General Chemistry, MESH: Cytoplasmic Vesicles/metabolism, Golgi apparatus, MESH: trans-Golgi Network/metabolism, Rats, MESH: Molecular Motor Proteins/metabolism, 030104 developmental biology, rab GTP-Binding Proteins, Biophysics, lcsh:Q, Rab, MESH: Nonmuscle Myosin Type IIA/metabolism, MESH: Microtubules/metabolism

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94563cceacba255a8dcff764307474b1Test
https://doi.org/10.1038/s41467-017-01266-0Test

8

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

المؤلفون: Paolo Paganetti, Pamela Valdés, Graham Knott, Bernard L. Schneider, Matthias Cacquevel, Catherine Maclachlan, Aurélien Lathuilière, Stéphanie Papin, Andreas Muhs

المصدر: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Scientific reports, Vol. 7, No 1 (2017) P. 13556

مصطلحات موضوعية: 0301 basic medicine, lcsh:Medicine, medicine.disease_cause, Microtubules, Mice, 0302 clinical medicine, Phosphorylation, Cognitive decline, lcsh:Science, Cytoskeleton, Cerebral Cortex, Neurons, Tau Proteins / genetics, Mutation, Multidisciplinary, biology, Chemistry, Neurons / metabolism, Prosencephalon / pathology, Cell biology, Cerebral Cortex / pathology, Protein Binding, Frontotemporal dementia, Microtubules / metabolism, Genetic Vectors, Tau protein, Prosencephalon / metabolism, Hyperphosphorylation, tau Proteins, Article, 03 medical and health sciences, Prosencephalon, Alzheimer Disease, Microtubule, mental disorders, Genetic Vectors / metabolism, medicine, Animals, Humans, Alzheimer Disease / pathology, lcsh:R, medicine.disease, Alzheimer Disease / metabolism, Mice, Inbred C57BL, 030104 developmental biology, Animals, Newborn, Cerebral Cortex / ultrastructure, Rotarod Performance Test, Mutagenesis, Site-Directed, biology.protein, lcsh:Q, Protein Conformation, beta-Strand, Tau Proteins / metabolism, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4a61a4863f9e037384c818204e8fafTest
https://doi.org/10.1038/s41598-017-13786-2Test

9

Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility

المؤلفون: Eun A. Ko, Harry A. T. Pritchard, Albert L. Gonzales, Scott Earley, Kenton M. Sanders, Grant W. Hennig, Bernard T. Drumm, Paulo W. Pires

المصدر: Pritchard, H A T, Gonzales, A L, Pires, P W, Drumm, B T, Ko, E A, Sanders, K M, Hennig, G W & Earley, S 2017, ' Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility ', Science Signaling, vol. 10, no. 497 . https://doi.org/10.1126/scisignal.aan2694Test

مصطلحات موضوعية: 0301 basic medicine, Male, Calcium Signaling/physiology, Biology, Biochemistry, Microtubules, Muscle, Smooth, Vascular, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, 0302 clinical medicine, Sarcoplasmic Reticulum/metabolism, Microtubule, medicine, Animals, Vasoconstriction/physiology, Calcium Signaling, Large-Conductance Calcium-Activated Potassium Channels, Cytoskeleton, Molecular Biology, Ryanodine receptor, Endoplasmic reticulum, Cardiac muscle, Ryanodine Receptor Calcium Release Channel, Cell Biology, Smooth muscle contraction, Large-Conductance Calcium-Activated Potassium Channels/metabolism, Actin cytoskeleton, Cell biology, Rats, Coupling (electronics), Sarcoplasmic Reticulum, 030104 developmental biology, medicine.anatomical_structure, Microtubules/metabolism, Muscle, Smooth, Vascular/cytology, Vasoconstriction, 030217 neurology & neurosurgery, Ryanodine Receptor Calcium Release Channel/metabolism, Muscle Contraction/physiology, Muscle Contraction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa85aa0c541ae7827eac6eeb2496fd34Test
https://pubmed.ncbi.nlm.nih.gov/28928237Test

10

Microtubule detyrosination guides chromosomes during mitosis

المؤلفون: Carsten Janke, Ana L. Pereira, Suvranta K. Tripathy, Anatoly V. Zaytsev, Maria M. Magiera, Helder Maiato, Ekaterina L. Grishchuk, Marin Barisic, Ricardo Silva e Sousa

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: Mitosis, macromolecular substances, Biology, Spindle pole body, 03 medical and health sciences, 0302 clinical medicine, Microtubule, Cell Line, Tumor, Chromosome Segregation, Detyrosination, Humans, Sarcosine/analogs & derivatives, Non-Histone/antagonists & inhibitors, 030304 developmental biology, Genetics, Spindle Apparatus/metabolism, 0303 health sciences, Chromosomal Proteins Non-Histone/metabolism, Multidisciplinary, Kinetochore, Sarcosine/pharmacology, Tubulin/metabolism, Molecular Imaging, Spindle apparatus, Cell biology, Chromosomal Proteins, Tubulin, Microtubules/metabolism, Chromosomal Proteins Non-Histone/genetics, Bridged Bicyclo Compounds Heterocyclic/pharmacology, biology.protein, Tyrosine/metabolism, Astral microtubules, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae16d669e28eecb53df4c0b4cb413103Test
https://doi.org/10.1126/science.aaa5175Test

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