Positive fibroblast growth factor receptor 3 immunoreactivity is associated with low-grade non-invasive urothelial bladder cancer
| العنوان: | Positive fibroblast growth factor receptor 3 immunoreactivity is associated with low-grade non-invasive urothelial bladder cancer |
|---|---|
| المؤلفون: | Eva Drescher, Maximilian Burger, Ferdinand Hofstaedter, Robert Stöhr, Arndt Hartmann, Qing Zhong, Thomas Hermanns, Peter J. Wild, Daniel Eberli, Tullio Sulser, Cédric Poyet, Ellen C. Zwarthoff |
| المساهمون: | University of Zurich, Poyet, Cédric, Internal Medicine, Pathology |
| المصدر: | Europe PubMed Central Oncology Letters Oncology Letters, 10(5), 2753-2760. Spandidos Publications |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | musculoskeletal diseases, Cancer Research, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, molecular markers, 610 Medicine & health, Biology, SDG 3 - Good Health and Well-being, 10049 Institute of Pathology and Molecular Pathology, medicine, Clinical significance, 1306 Cancer Research, fibroblast growth factor receptor 3 protein, Univariate analysis, Tissue microarray, Bladder cancer, grading, Articles, Fibroblast growth factor receptor 3, medicine.disease, musculoskeletal system, Molecular medicine, 10062 Urological Clinic, stomatognathic diseases, Oncology, urothelial cancer, Immunohistochemistry, 2730 Oncology, prognosis, Immunostaining |
| الوصف: | In addition to conventional clinicopathological parameters, molecular markers are also required in order to predict the course of disease in patients with urothelial bladder cancer(BC). Little is known about fibroblast growth factor receptor 3 (FGFR3) immunoreactivity and the clinical significance it may possess with regard to BC. The present study aimed to investigate the immunoreactivity of FGFR3 in primary urothelial bladder tumours, with regard to clinicopathological features and FGFR3 mutation status. Tissue microarrays were used to immunohistochemically analyse FGFR3 expression in 255 primary, unselected patients with BC. FGFR3 mutations were detected using SNaPshot analysis. Positive FGFR3 immunoreactivity was identified in 113/207 analysable cases (54.6%), and was significantly associated with FGFR3 mutation (P |
| وصف الملف: | Poyet_OncolLetter_2015.pdf - application/pdf |
| تدمد: | 1792-1074 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6e0ebb5408fad940b3a99259d4f5f2Test https://doi.org/10.3892/ol.2015.3691Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d6e0ebb5408fad940b3a99259d4f5f2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921074 |
|---|