المؤلفون: Amminger, G Paul, Rice, Simon, Davey, Christopher G, Quinn, Amelia L, Hermens, Daniel F, Zmicerevska, Natalia, Nichles, Alissa, Hickie, Ian, Incerti, Lisa, Weller, Amber, Joseph, Sarah, Hilton, Zarah, Pugh, Charlotte, Rayner, Madeline, Reid, Nate, Ratheesh, Aswin, Yung, Alison R, Yuen, Hok Pan, Mackinnon, Andrew, Hetrick, Sarah, Parker, Alexandra, Street, Rebekah, Berger, Maximus, Berk, Michael, McGorry, Patrick D, Lin, Ashleigh

مصطلحات موضوعية: 610 Medicine & health

الوصف: BACKGROUND Clinical trials suggest long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA; 'fish oil') may reduce depressive symptoms in adults with MDD. Hence, n-3 PUFA may be a potential treatment for depression in youth. METHODS Participants were aged 15-25 years with MDD who sought care in one of three government-funded mental health services for young people in metropolitan Melbourne, Perth, or Sydney, Australia. Participants were randomly assigned in a double-blind, parallel-arm design to receive 'fish oil' (840 mg of eicosapentaenoic acid and 560 mg of docosahexaenoic acid) or placebo capsules as adjunct to cognitive behavioural case management (CBCM). All participants were offered fortnightly 50-minute CBCM sessions delivered by qualified therapists (treatment as usual) at the study sites during the intervention period. The primary outcome was change in the interviewer-rated Quick Inventory of Depressive Symptomatology, Adolescent Version (QIDS-A17-C) score at 12 weeks. Erythrocyte n-3 PUFA levels were assessed pre-post intervention. RESULTS 233 young people were randomised to the treatment arms: 115 participants to the n-3 PUFA and 118 to the placebo group. Mean change from baseline in the QIDS-A17-C score was -5.8 in the n-3 PUFA group and -5.6 in the placebo group (mean difference, 0.2; 95% CI -1.1 to 1.5; p=0.75). Erythrocyte PUFA levels were not associated with depression severity at any timepoint. The incidence and severity of adverse events were similar in the two groups. CONCLUSIONS This placebo-controlled trial and biomarker analysis found no evidence to support the use of fish oil for treatment in young people with MDD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f3902a0b1fb58febcb6341f6cf1d2688Test

المؤلفون: Moller, Carl I., Badcock, Paul B., Hetrick, Sarah E., Rice, Simon, Berk, Michael, Dean, Olivia M., Chanen, Andrew M., Gao, Caroline, Davey, Christopher G., Cotton, Sue M.

مصطلحات موضوعية: FOS: Psychology, 170199 Psychology not elsewhere classified

الوصف: Supplemental Material for Assessing Suicidal Ideation in Young People With Depression: Factor Structure of the Suicidal Ideation Questionnaire by Carl I. Moller, Paul B. Badcock, Sarah E. Hetrick, Simon Rice, Michael Berk, Olivia M. Dean, Andrew M. Chanen, Caroline. Gao, Christopher G. Davey and Sue M. Cotton in Journal of Death and Dying

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0246330f48553f3657227e8412fed1d7Test

المؤلفون: Lampit, Amit, Launder, Nathalie H., Minkov, Ruth, Rollini, Alice, Davey, Christopher G., Finke, Carsten, Lautenschlager, Nicola T., Gavelin, Hanna Malmberg

الوصف: Additional file 1: PRISMA-P checklist.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d3a8921dacaa56ad4ba26c2adb7cbeTest

المؤلفون: Lampit, Amit, Launder, Nathalie H., Minkov, Ruth, Rollini, Alice, Davey, Christopher G., Finke, Carsten, Lautenschlager, Nicola T., Gavelin, Hanna Malmberg

مصطلحات موضوعية: education, mental disorders, health care economics and organizations

الوصف: Additional file 2: Search strategy (MEDLINE, EMBASE and PsycINFO on Ovid).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce364d969bb6739822f85f4648886a9Test

المؤلفون: Han, Laura KM, Dinga, Richard, Hahn, Tim, Ching, Christopher RK, Eyler, Lisa T, Aftanas, Lyubomir, Aghajani, Moji, Aleman, André, Baune, Bernhard T, Berger, Klaus, Brak, Ivan, Filho, Geraldo Busatto, Carballedo, Angela, Connolly, Colm G, Couvy-Duchesne, Baptiste, Cullen, Kathryn R, Dannlowski, Udo, Davey, Christopher G, Dima, Danai, Duran, Fabio LS, Enneking, Verena, Filimonova, Elena, Frenzel, Stefan, Frodl, Thomas, Fu, Cynthia HY, Godlewska, Beata R, Gotlib, Ian H, Grabe, Hans J, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Hall, Geoffrey B, Harrison, Ben J, Hatton, Sean N, Hermesdorf, Marco, Hickie, Ian B, Ho, Tiffany C, Hosten, Norbert, Jansen, Andreas, Kähler, Claas, Kircher, Tilo, Klimes-Dougan, Bonnie, Krämer, Bernd, Krug, Axel, Lagopoulos, Jim, Leenings, Ramona, MacMaster, Frank P, MacQueen, Glenda, McIntosh, Andrew, McLellan, Quinn, McMahon, Katie L, Medland, Sarah E, Mueller, Bryon A, Mwangi, Benson, Osipov, Evgeny, Portella, Maria J, Pozzi, Elena, Reneman, Liesbeth, Repple, Jonathan, Rosa, Pedro GP, Sacchet, Matthew D, Sämann, Philipp G, Schnell, Knut, Schrantee, Anouk, Simulionyte, Egle, Soares, Jair C, Sommer, Jens, Stein, Dan J, Steinsträter, Olaf, Strike, Lachlan T, Thomopoulos, Sophia I, van Tol, Marie-José, Veer, Ilya M, Vermeiren, Robert RJM, Walter, Henrik, van der Wee, Nic JA, van der Werff, Steven JA, Whalley, Heather, Winter, Nils R, Wittfeld, Katharina, Wright, Margaret J, Wu, Mon-Ju, Völzke, Henry, Yang, Tony T, Zannias, Vasileios, de Zubicaray, Greig I, Zunta-Soares, Giovana B, Abé, Christoph, Alda, Martin, Andreassen, Ole A, Bøen, Erlend, Bonnin, Caterina M, Canales-Rodriguez, Erick J, Cannon, Dara, Caseras, Xavier, Chaim-Avancini, Tiffany M, Elvsåshagen, Torbjørn, Favre, Pauline, Foley, Sonya F, Fullerton, Janice M

المصدر: Molecular psychiatry, vol 26, iss 9

مصطلحات موضوعية: Adult, Male, Aging, Adolescent, Major Depressive Disorder, Medical and Health Sciences, Young Adult, Clinical Research, 2.3 Psychological, Behavioral and Social Science, Humans, Longitudinal Studies, Aetiology, Aged, Psychiatry, Depressive Disorder, Depression, Psychology and Cognitive Sciences, Neurosciences, Brain, Major, Middle Aged, Biological Sciences, Serious Mental Illness, Magnetic Resonance Imaging, Brain Disorders, Mental Health, Biomedical Imaging, Female, social and economic factors

الوصف: Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______325::f0701503e202e31764c0a53afb622338Test
https://escholarship.org/uc/item/8bw8p2dwTest

المؤلفون: Rice, Simon, Gleeson, John, Davey, Christopher G., Hetrick, Sarah, Parker, Alexandra, Lederman, Reeva, Wadley, Greg, Murray, Greg, Herrman, Helen, Chambers, Richard, Russon, Penni, Miles, Christopher, D'Alfonso, Simon, Thurley, Melissa, Chinnery, Gina, Gilbertson, Tamsyn, Eleftheriadis, Dina, Barlow, Emma, Cagliarini, Daniella, Toh, Jia-Wern, Mcalpine, Stuart, Koval, Peter, Bendall, Sarah, Jansen, Jens Einar, Hamilton, Matthew, McGorry, Patrick, Alvarez-Jimenez, Mario

المصدر: Early intervention in psychiatry. 12(4)

مصطلحات موضوعية: Psychiatry, Adult, Male, Adolescent, Depression, Remission Induction, 1103 Clinical Sciences, 1701 Psychology, Pilot Projects, Peer Group, Telemedicine, Social Networking, Young Adult, Recurrence, Secondary Prevention, Humans, Female, internet

الوصف: Aim: Implementation of targeted e-mental health interventions offers a promising solution to reducing the burden of disease associated with youth depression. A single-group pilot study was conducted to evaluate the acceptability, feasibility, usability and safety of a novel, moderated online social therapy intervention (entitled Rebound) for depression relapse prevention in young people. Methods: Participants were 42 young people (15–25 years) (50% men; mean age = 18.5 years) in partial or full remission. Participants had access to the Rebound platform for at least 12 weeks, including the social networking, peer and clinical moderator and therapy components. Results: Follow-up data were available for 39 (92.9%) participants. There was high system usage, with 3034 user logins (mean = 72.2 per user) and 2146 posts (mean = 51.1). Almost 70% of users had ≥10 logins over the 12 weeks, with 78.5% logging in over at least 2 months of the pilot. A total of 32 (84%) participants rated the intervention as helpful. There was significant improvement between the number of participants in full remission at baseline (n = 5; none of whom relapsed) relative to n = 19 at 12-week follow-up (P < 0.001). Six (14.3%) participants relapsed to full threshold symptoms at 12 weeks. There was a significant improvement to interviewer-rated depression scores (Montgomery–Asberg Depression Rating Scale (MADRS); P = 0.014, d = 0.45) and a trend for improved strength use (P = 0.088, d = 0.29). The single-group design and 12-week treatment phase preclude a full understanding of the clinical benefits of the Rebound intervention. Conclusions: The Rebound intervention was shown to be acceptable, feasible, highly usable and safe in young people with major depression.

وصف الملف: Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4a58d908cc8d78987ce525f5e58e8122Test
https://pubmed.ncbi.nlm.nih.gov/27311581Test

المؤلفون: Via, Esther, Soriano-Mas, Carles, Isabel María Sánchez Diaz, Forcano, Laura, Davey, Christopher G., Harrison, Ben J., Martinez-Zalacain, Ignacio, Hernandez-Ribas, Rosa, Pujol, Jesus, Menchon, Jose M., Fernandez-Aranda, Fernando, Cardoner, Narcis

المصدر: ResearcherID
Web of Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4161b2eeea7d96b364eab4baa15dc022Test
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000334101802263&KeyUID=WOS:000334101802263Test