المؤلفون: Hüseyin Nezih Özdemir, Birgül Dere, Asım Orujov, Gülcan Neşem Başkan, Mehmet Mesut Dorukoğlu, Hadiye Şirin, Neşe Çelebisoy, Figen Gökçay

المصدر: Turkish Journal Of Neurology. 28:111-117

مصطلحات موضوعية: retroorbital headache, brain stem injury, temporal cortex, retrospective study, shorter, cranial neuropathy, middle aged, pain, nuclear magnetic resonance imaging, trigeminal autonomic cephalalgia, SUNCT syndrome, miosis, eyelid edema, frontal cortex, adult, hemicranial, Headache, cluster headache, indometacin, hemicranial headache, trigeminus neuralgia, aged, female, agitation, face pain, sweating, carbamazepine, hypnic headache, disease severity, brain, unilateral retroorbital, Article, nose obstruction, restlessness, male, demographics, ptosis (eyelid), cross-sectional study, follow up, controlled study, tension headache, human, paroxysmal hemicrania, hemifacial, treatment failure, conjunctival drug administration, autonomic nervous system, face, visual analog scale, treatment response, unilateral supraorbital headache, clinical feature, Neurology (clinical), cough headache, stabbing headache

الوصف: Objective: The aim of our research was to evaluate the demographic and clinical features, treatment characteristics, and responses of the patients who presented to the Ege University Neurology Headache Outpatient Clinic with headaches lasting less than 4 hours. Another primary goal was to compare the characteristics mentioned above of patients with and without cranial autonomic symptoms. Materials and Methods: Our study was retrospective and cross-sectional. The findings were based on the data collected at our tertiary headache center. Headache disorder diagnoses were made in accordance with the International Classification of Headache Disorders-3 guideline. We reviewed the patients’ charts and recorded the information on a standardized form. The patients’ clinical features, and treatment responses were noted. The patients were divided into two groups as those with and without autonomic findings, and the above-mentioned features were compared. Treatment responses of patients with trigeminal autonomic cephalgia (TAC) and patients with trigeminal neuralgia (TN) were analyzed via logistic regression analysis. Values of p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e166598649c59c61d9e55a62b0e6547Test
https://doi.org/10.4274/tnd.2022.14564Test

المؤلفون: Gusev, V. V., Kovtun, O. P., Lvova, O. A., Partylova, E. A., Sergeev, A. P., Sergeeva, M. V., Yanchuk, I. T., Dobrazova, D. A., Suvorkov, P. A., Shamalov, N. A.

المصدر: Nevrologiya, Neiropsikhiatriya, Psikhosomatika

مصطلحات موضوعية: FIBRINOGEN BETA, GENETIC VARIABILITY, PARALYSIS, SINGLE NUCLEOTIDE SUBSTITUTIONS, MAJOR CLINICAL STUDY, UNCLASSIFIED DRUG, CLINICAL FEATURE, BETA3 INTEGRIN, ATRIAL FIBRILLATION, COMPUTER ASSISTED TOMOGRAPHY, HYPERLIPIDEMIA, CEREBROVASCULAR MALFORMATION, PARESIS, HUMAN, RISK FACTOR, BRACHIOCEPHALIC ARTERY STENOSIS, FEMALE, Psychiatry and Mental health, Clinical Psychology, METABOLIC DISORDER, BRAIN VASCULITIS, MIGRAINE, HOSPITALIZATION, RISK FACTORS, ISCHEMIC STROKE, ATHEROSCLEROTIC PLAQUE, BLOOD CLOTTING FACTOR 7, NUCLEIC ACID BASE SUBSTITUTION, HEART LEFT VENTRICLE HYPERTROPHY, BLOOD CLOTTING FACTOR 5, PLASMINOGEN ACTIVATOR INHIBITOR 1, COHORT ANALYSIS, GENETIC PREDISPOSITION, BRAIN INFARCTION, HETEROZYGOTE, NUCLEAR MAGNETIC RESONANCE IMAGING, ADULT, DNA POLYMORPHISM, MITRAL VALVE PROLAPSE, DYSLIPOPROTEINEMIA, ALPHA2 INTEGRIN, ARTICLE, FIBRINOGEN, ERYTHROCYTE SEDIMENTATION RATE, HOSPITAL ADMISSION, MALE, OCCLUSIVE CEREBROVASCULAR DISEASE, SPEECH DISORDER, YOUNG AGE, CONTROLLED STUDY, ANAMNESIS, INTENSIVE CARE, THROMBOPHILIA, Neurology (clinical), RANKIN SCALE, SELF CARE

الوصف: Objective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients.Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G.Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients.Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3715bffc4b929ba15399a93f26fa3334Test
https://doi.org/10.14412/2074-2711-2022-3-12-18Test

المؤلفون: Giuseppe Carrà, Jonathan Savitz, Riccardo Matteo Cioni, Tommaso Callovini, Daniele Cavaleri, Blazej Misiak, Cristina Crocamo, Francesco Bartoli

المساهمون: Bartoli, F, Cioni, R, Cavaleri, D, Callovini, T, Crocamo, C, Misiak, B, Savitz, J, Carra', G

المصدر: European psychiatry : the journal of the Association of European Psychiatrists. 65(1)

مصطلحات موضوعية: Psychiatry and Mental health, Affect, Bipolar Disorder, Tryptophan, Humans, Kynurenine, clinical feature, kynurenine pathway, Signal Transduction

الوصف: Background The balance between neurotoxic and neuroprotective effects of kynurenine pathway (KP) components has been recently proposed as a key element in the pathophysiology of bipolar disorder (BD) and related mood episodes. This comprehensive overview explored the link of KP with symptom severity and other clinical features of BD. Methods We searched Medline, Embase, and PsycInfo electronic databases for studies assessing the association of peripheral and/or central concentrations of KP metabolites with putative clinical features, including symptom severity and other clinical domains in BD. Results We included the findings of 13 observational studies investigating the possible variations of KP metabolites according to symptom severity, psychotic features, suicidal behaviors, and sleep disturbances in BD. Studies testing the relationship between KP metabolites and depression severity generated mixed and inconsistent findings. No statistically significant correlations with manic symptoms were found. Moreover, heterogeneous variations of the KP across different clinical domains were shown. Few available studies found (a) higher levels of cerebrospinal fluid kynurenic acid and lower of plasma quinolinic acid in BD with psychotic features, (b) lower central and peripheral picolinic acid levels in BD with suicide attempts, and (c) no significant correlations between KP metabolites and BD-related sleep disturbances. Conclusions An imbalance of KP metabolism toward the neurotoxic branches is likely to occur in people with BD, though evidence on variations according to specific clinical features of BD is less clear. Additional research is needed to clarify the role of KP in the etiopathogenesis of BD and related clinical features.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d4493dfa2bfcc320b5941b2cc73bc7Test
https://pubmed.ncbi.nlm.nih.gov/36366795Test

المؤلفون: Yukiko Kanetsuna, Masamichi Shinonaga, Hiroshi Kanno

المصدر: World Journal of Clinical Oncology

مصطلحات موضوعية: Myxopapillary ependymoma, medicine.medical_specialty, Anaplastic feature, Clinical feature, Oncology, business.industry, Case report, Medicine, Radiology, Pathological feature, business, Management

الوصف: BACKGROUND Myxopapillary ependymoma (MPE) is a pathological grade I tumor that arises in the filum terminale. MPE with anaplastic features is extremely rare, and only 5 cases have shown malignancy at the time of recurrence. CASE SUMMARY The patient (a 46-year-old woman) had undergone a MPE operation 30 years ago. After subtotal resection of the tumor located in L4-S1, it had a solid component that extended to the adjacent subcutaneous region. Histologically, the tumor consisted of a typical MPE with anaplastic features. The anaplastic areas of the tumor showed hypercellularity, a rapid mitotic rate, vascular proliferation, and connective tissue proliferation. Pleomorphic cells and atypical mitotic figures were occasionally observed. The MIB-1 index in this area was 12.3%. The immunohistochemical study showed immunoreactivity for vimentin, glial fibrillary acidic protein and S100. The morphological pattern and immunohistochemical profile were consistent with anaplastic MPE. The patient tolerated surgery well without new neurological deficits. She underwent local irradiation for the residual tumor and rehabilitation. CONCLUSION Although extremely rare, anaplastic MPE occurs in both pediatric and adult patients, similar to other ependymomas. At a minimum, close monitoring is recommended, given concerns about aggressive biological potential. In the future, further study is needed to determine the WHO classification criteria and genetic indicators of tumor progression. The possibility of malignant transformation of MPE should be taken into account, and patients with MPE should be treated with care and follow-up.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23615b89667ea1e83de0d899ca9ceec7Test
https://doi.org/10.5306/wjco.v12.i11.1072Test

المؤلفون: Hülya Sungurtekin, Cansu Ozgen, Ulku Arslan, Kemal Tolga Saracoglu, Volkan Yarar, Ahmet Sari, Ayse Turan Civraz, Ali Aydin Altunkan, Hilal Ayoglu, Nilgun Kavrut Ozturk, Nihal Bulut Yuksel, Birgul Yelken, Elif Bombaci, Gokhan Kilinc, Damla Akman, Pinar Demir, Ferruh Ayoglu, Fulya Ciyiltepe, Ahmet Caliskan, Simay Karaduman

المصدر: Annals of Saudi Medicine
Annals of Saudi Medicine, Vol 41, Iss 6, Pp 318-326 (2021)

مصطلحات موضوعية: antivirus agent, Male, demography, Turkey, retrospective study, clinical outcome, oxygen therapy, intensive care unit, Turkey (republic), computer assisted tomography, aspartate aminotransferase, antibiotic agent, interleukin 6 receptor, APACHE, thorax radiography, fever, C reactive protein, lopinavir plus ritonavir, adult, steroid, General Medicine, hydroxychloroquine sulfate, adult respiratory distress syndrome, cohort analysis, aged, comorbidity, Intensive Care Units, female, survivor, convalescent plasma, Medicine, Original Article, headache, hospitalization, hydroxychloroquine, pleura effusion, oseltamivir, alanine aminotransferase, favipiravir, lung nodule, Article, lung infiltrate, tocilizumab, coronavirus disease 2019, invasive ventilation, turkey (bird), ground glass opacity, Sequential Organ Failure Assessment Score, Humans, controlled study, human, coughing, hypertensive agent, Retrospective Studies, SARS-CoV-2, ferritin, respiratory failure, COVID-19, dyspnea, major clinical study, mortality, real time reverse transcription polymerase chain reaction, enfluvir, clinical feature, neutrophil lymphocyte ratio, multicenter study, adolescent, prone position, oxygen

الوصف: BACKGROUND: In our previous report on Turkish COVID-19 patients requiring intensive care, the 24 patients in a single ICU were elderly and mortality was high. We extended our analysis to include patients admitted to ten ICUs. OBJECTIVES: Report the demographics, clinical features, imaging findings, comorbidities, and outcomes in COVID-19 patients. DESIGN: Retrospective. SETTING: Intensive care unit. PATIENTS AND METHODS: The study includes patients with clinical and radiological confirmed or laboratory-confirmed COVID-19 infection who were admitted to ten ICUs between 15 March and 30 June 2020. MAIN OUTCOME MEASURES: Clinical outcomes, therapies, and death during hospitalization SAMPLE SIZE: 974, including 571 males (58%). RESULTS: The median age (range) was 72 (21–101) years for patients who died (n=632, 64.9%) and 70 (16–99) years for patients who lived (n=342, 35.2%) ( P P P =.013). Most (n=719, 73.8%) underwent invasive mechanical ventilation therapy. CONCLUSIONS: The majority of patients admitted to the ICU with a diagnosis of COVID-19 require respiratory support. LIMITATIONS: Although the Turkish Ministry of Health made recommendations for the treatment of COVID-19 patients, patient management may not have been identical in all ten units. CONFLICT OF INTEREST: None.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f382ce319ff242f08089d2966a6a811Test
https://doi.org/10.5144/0256-4947.2021.318Test

المؤلفون: Guoshu Bi, Valeria Besskaya, Huan Zhang, Jiaqi Liang, Guangyao Shan, Songtao Xu, Zhencong Chen, Lin Wang, Yuansheng Zheng, Cheng Zhan, Weigang Guo, Benjie Cai

المصدر: Thoracic Cancer, Vol 12, Iss 22, Pp 3011-3018 (2021)
Thoracic Cancer

مصطلحات موضوعية: Adult, Male, ALK inhibitors, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Adenocarcinoma of Lung, Pulmonary Surgical Procedures, Targeted therapy, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Anaplastic Lymphoma Kinase, Radical surgery, Stage (cooking), Pathological, RC254-282, Aged, Retrospective Studies, Gene Rearrangement, Univariate analysis, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, lung adenocarcinoma, medicine.disease, Primary tumor, clinical feature, Survival Rate, anaplastic lymphoma kinase (ALK), Case-Control Studies, Adenocarcinoma, Female, Original Article, prognosis, business

الوصف: Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods This was a retrospective cohort study of 80 ALK‐rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation‐negative patients were retrospectively reviewed for inclusion in this case‐controlled analyses. Overall survival (OS) was evaluated using the Kaplan‐–Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS. Results Compared to ALK‐negative patients, the ALK rearranged patients were younger, with more non‐smokers, more females, a larger primary tumor was demonstrated, and were a higher pathological stage. In particular, the risk of lymph node metastasis was higher. For patients with surgically‐resected tumors, the prognosis was better for ALK rearranged patients (HR = 0.503; 95% CI: 0.259–0.974, p = 0.041). In addition, for stage II–III patients, targeted therapy was an independent prognostic factor of better OS (HR = 0.159; 95% CI: 0.032–0.801, p = 0.026). Conclusions ALK rearranged lung adenocarcinoma patients who have undergone radical surgery have distinct clinical features. Patients with ALK rearrangement may have a favorable prognosis, and stage II–III patients may benefit from targeted treatment.
The article compared 80 ALK+ and 3031 ALK‐ lung adenocarcinoma patients after surgery, explored the clinicopathological characteristics and prognostic features of ALK+ lung adenocarcinoma patients, and analyzed the impact of targeted drugs on the survival of ALK+ lung adenocarcinoma patients after surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78722f929edd2f16157d56c3e4829be9Test
https://doi.org/10.1111/1759-7714.14170Test

المؤلفون: Yi Pang Lee, Ming Jane Lang, Yang Che Wu, Chun-Pin Chiang, Ming Jay Hwang, Yu Hsueh Wu

المصدر: Journal of Dental Sciences
Journal of Dental Sciences, Vol 16, Iss 4, Pp 1140-1145 (2021)

مصطلحات موضوعية: Radiography, Root canal, Radiodensity, Scars, Dentistry, Mandibular second molar, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Radiographic feature, medicine, Histopathological feature, General Dentistry, Periapical scar, business.industry, Mandible, RK1-715, 030206 dentistry, Periodontium, stomatognathic diseases, medicine.anatomical_structure, Clinical feature, 030220 oncology & carcinogenesis, Maxilla, Original Article, medicine.symptom, business

الوصف: Background/purpose Periapical scar (PS) is an alternative healing process with the formation of scar tissue after appropriate endodontic treatments/retreatments with or without periapical surgeries. This retrospective study evaluated the clinical, radiographic, and histopathological features of 7 PSs. Materials and methods The clinical, radiographic, and histopathological data of 7 PSs were collected and analyzed. Results The 7 PSs were taken from the maxilla (3 cases) and mandible (4 cases) of 3 men and 4 women. The most frequently involved teeth were maxillary or mandibular incisors (4 cases) and first or second molars (3 cases). Of 7 PS patients, 6 had none of symptoms, 5 had previous nonsurgical endodontic treatments/retreatments, and 2 had previous endodontic treatments/retreatments plus periapical surgery. Radiographically, all 7 PS cases presented as a persistent and well-defined periapical radiolucent lesion for a long period of time. Microscopically, all 7 surgical specimens of PS showed dense fibrous collagenous tissues with one having amalgam particles in the scar tissue. Conclusion PSs do have their common clinical and radiographic features. When the periapical radiolucent lesion is well-defined, persistent without a significant change of its size, and free from symptoms and signs after a long-term follow-up; the involved tooth has no evidence of root fracture and healthy periodontium except the periapical radiolucency; and the previous endodontic treatment/retreatment or periapical surgery is well performed with an adequate root canal or retrograde filling, then the PS may be a possible diagnosis and a close follow-up may be a more conservative treatment strategy for this condition.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8958dc7f9a290a98b0c8c725872aa03eTest
https://doi.org/10.1016/j.jds.2021.05.008Test

المؤلفون: Elena R. Lebedeva, Anton V. Ushenin, Natalia M. Gurary, Denis V. Gilev, Nadezda V. Kislyak, Jes Olesen

المصدر: Journal of Headache and Pain
Lebedeva, E R, Ushenin, A V, Gurary, N M, Gilev, D V, Kislyak, N V & Olesen, J 2022, ' Persistent headache after first-ever ischemic stroke : clinical characteristics and factors associated with its development ', Journal of Headache and Pain, vol. 23, 103 . https://doi.org/10.1186/s10194-022-01479-9Test

مصطلحات موضوعية: Male, DISEASE DURATION, MAJOR CLINICAL STUDY, BODY MASS, CLINICAL FEATURE, INTERNATIONAL CLASSIFICATION OF HEADACHE DISORDERS, PHOTOPHOBIA, TENSION HEADACHE, DRUG INDUCED HEADACHE, HEADACHE, Headache Disorders, Secondary, POST-STROKE PAIN, BRAIN ISCHEMIA, SECONDARY HEADACHE, MIGRAINE WITH AURA, Headache, HUMAN, PHONOPHOBIA, HUMANS, COMPLICATION, General Medicine, SEMI STRUCTURED INTERVIEW, Middle Aged, FEMALE, PREVALENCE, FOLLOW UP, Stroke, DISEASE SEVERITY, ISCHEMIC STROKE, NATIONAL INSTITUTES OF HEALTH STROKE SCALE, Female, CLUSTER HEADACHE, STROKE, ANALGESIC AGENT, PERSISTENT HEADACHE, CEREBROVASCULAR ACCIDENT, HEADACHE DISORDERS, SECONDARY, PATIENT, TRIPTAN DERIVATIVE, ALCOHOL CONSUMPTION, ADULT, QUALITY OF LIFE, Humans, ARTICLE, CEREBELLUM, Ischemic Stroke, MALE, SLEEP DEBT, MIDDLE AGED, CONTROLLED STUDY, Anesthesiology and Pain Medicine, MEDICATION OVERUSE HEADACHE, MIGRAINE WITHOUT AURA, Quality of Life, Neurology (clinical), INCIDENCE, VOMITING

الوصف: Background It is poorly described how often headache attributed to stroke continues for more than 3 months, i.e. fulfils the criteria for persistent headache attributed to ischemic stroke. Our aims were: 1) to determine the incidence of persistent headache attributed to past first-ever ischemic stroke (International headache society categories 6.1.1.2); 2) to describe their characteristics and acute treatment; 3) to analyse the prevalence of medication overuse headache in patients with persistent headache after stroke; 4) to evaluate factors associated with the development of persistent headache after stroke. Methods The study population consisted of 550 patients (mean age 63.1, 54% males) with first-ever ischemic stroke, among them 529 patients were followed up at least three months after stroke. Standardized semi-structured interview forms were used to evaluate these headaches during professional face-to-face interviews at stroke onset and telephone interviews at 3 months. Results At three months, 61 patients (30 women and 31 men, the mean age 60.0) of 529 (11.5%) follow-up patients had a headache after stroke: 34 had a new type of headache, 21 had a headache with altered characteristics and 6 patients had a headache without any changes. Therefore 55 (10.4%) patients had a persistent headache attributed to ischemic stroke. Their clinical features included: less severity of accompanying symptoms, slowly decreasing frequency and development of medication overuse headache in one-third of the patients. The following factors were associated with these headaches: lack of sleep (29.1%, p = 0.009; OR 2.3; 95% CI 1.2–4.3), infarct in cerebellum (18.2%, p = 0.003; OR 3.0; 95% CI 1.4–6.6), stroke of undetermined etiology (50.9%, p = 0.003; OR 2.3; 95% CI 1.3–4.1), less than 8 points by NIHSS score (90.9%, p = 0.007; OR 3.4; 95% CI 1.4–8.6) and low prevalence of large-artery atherosclerosis (12.7%, p = 0.006; OR 0.3; 95% CI 0.2–0.80). Conclusion Persistent headache attributed to ischemic stroke is not rare and frequently leads to medication overuse. The problem is often neglected because of other serious consequences of stroke but actually, it has a considerable impact on quality of life. It should be a focus of interest in the follow-up of stroke patients.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e67c892ec230a220b3c317cf31f12eTest
https://doi.org/10.21203/rs.3.rs-1904685/v1Test

المؤلفون: GÖNÜLTAŞ, CEREN, KÖKER, İBRAHİM HAKKI, Destek, Sabahattin, TOPRAK, HÜSEYİN, Yapalak, Yunus, ŞENTÜRK, HAKAN, DEĞER, KAMURAN CUMHUR

المساهمون: GÖNÜLTAŞ, CEREN, TOPRAK, HÜSEYİN, KÖKER, İBRAHİM HAKKI, DEĞER, KAMURAN CUMHUR, ŞENTÜRK, HAKAN

مصطلحات موضوعية: Male, Pancreatic Neoplasms, Anesthesiology and Pain Medicine, Pancreatitis, Chronic, Emergency Medicine, Humans, Surgery, Cholecystectomy, Middle Aged, A single center experience with review of the literature-, ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.28, sa.8, ss.1186-1192, 2022 [DEĞER K. C. , KÖKER İ. H. , Destek S., TOPRAK H., Yapalak Y., GÖNÜLTAŞ C., ŞENTÜRK H., -The clinical feature and outcome of groove pancreatitis in a cohort], Pancreas

الوصف: Groove pancreatitis (GP) is a rare form of chronic pancreatitis that is less common and is now gaining awareness with multimodal imaging modalities. Our aim is to analyze the mid-long term outcomes of patients diagnosed with GP with different treatment approaches.A computerized search from electronic patient record database between May 2013 and June 2019 with the keywords 'groove', 'paraduodenal' was applied. The clinical, radiological and pathological data of 25 patients diagnosed with GP were obtained.In the GP patient group, the median age was 55 (25-87) and 80% was male. Alcohol and tobacco abuse was 40% among GP patients. The most common symptoms were upper abdominal pain (84%) and nausea-vomiting (40%), respectively. Gastric outlet obstruction was observed in 4 (16%) patients. CT and EUS imaging were performed to majority of cases (96% and 92 %, respectively). EUS-FNA was done in 14 of 25 (56%) patients. It was reported as atypia, adenocarcinoma and benign in 2 (8%), 2 (8%) and 10 (40%) patients, respectively. EUS-FNA was helpful to diagnose two pancreatic head adenoCA whose preliminary radiological evaluation was GP. The mean follow-up period was 29 (3-71) months. Conservative approach was the predominantly preferred treatment (%56). Apart from conservative approach, treatment strategies included biliary stenting, sphincterotomy, wirsung stenting via ERCP, cholecystectomy etc. Considering all treatment modalities, symptoms improved in 12 (48%) patients and progressed with recurrent pancreatitis attacks in 7 (28%) patients.Because GP is a less well-known form of pancreatitis, it presents several challenges for clinicians in diagnosis and treatment. This form, which can mimic pancreatic malignancy in particular, must be differentiated from carcinoma. EUS(±FNA) is a useful diagnostic tool complementary to imaging. Although the conservative approach remains the first choice in most patients, the clinician should consider invasive endoscopic procedures and surgical options in special cases when necessary.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f7755292550c1311c11bcee59e8712Test
http://hdl.handle.net/20.500.12645/31083Test

المؤلفون: Ming Jay Hwang, Ming Jane Lang, Yu Hsueh Wu, Ling Huey Chueh, Chun-Pin Chiang, Yi Pang Lee

المصدر: Journal of Dental Sciences, Vol 16, Iss 3, Pp 825-830 (2021)
Journal of Dental Sciences

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Root canal, macromolecular substances, Actinomycosis, Mandibular second molar, 03 medical and health sciences, 0302 clinical medicine, medicine, Histopathological feature, General Dentistry, Radicular cyst, Sinus (anatomy), Radicular Cyst, business.industry, Mandible, RK1-715, 030206 dentistry, medicine.disease, Periradicular, medicine.anatomical_structure, Clinical feature, Dentistry, 030220 oncology & carcinogenesis, Maxilla, Original Article, business

الوصف: Background/purpose Actinomycosis is sometimes associated with a radicular cyst (RC). This retrospective study evaluated the clinical and histopathological features of 6 RCs with actinomycosis (AM/RCs). Materials and methods The demographic data and clinicopathological features of 6 AM/RCs were collected and analyzed. Results The 6 AM/RCs were taken from 2 male and 4 female patients, and 3 were found in the maxilla and the other 3 in the mandible. The involved teeth included maxillary or mandibular incisors (2 cases) and maxillary or mandibular first and second molars (4 cases). The most common symptom was pain (5 cases) and the more frequent signs were sinus tract and pus discharge (4 cases). Microscopically, the actinomycotic colony presented as a mass with filamentous bacteria arranging in a sun-ray pattern at the periphery. The mean actinomycotic colony number was 7.7 ± 6.6 colonies per slide. Due to the severe inflammation in all 6 AM/RCs, the stratified squamous epithelial lining was completely abolished in 2 cases and partially destroyed in 4 cases with the residual epithelial lining varying from approximately 10%–50%. Conclusion Our results indicate that pain is the most common symptom and sinus tract and pus discharge are the two frequent signs of our 6 AM/RCs. The stratified squamous epithelial lining was either completely abolished (2 cases) or partially destroyed (4 cases) in 6 AM/RCs. Thus, if the endodontically-treated tooth shows a recurrent sinus tract and poor response to repeated conventional root canal treatments, periradicular actinomycotic infection should be highly suspected.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb8eb17ea7c9140207263f5b1cfad6aTest
https://doi.org/10.1016/j.jds.2021.04.008Test